ID APRF_HUMAN STANDARD; PRT; 770 AA. AC P40763; DT 01-FEB-1995 (REL. 31, CREATED) DT 01-FEB-1995 (REL. 31, LAST SEQUENCE UPDATE) DT 01-FEB-1995 (REL. 31, LAST ANNOTATION UPDATE) DE ACUTE-PHASE RESPONSE FACTOR. GN APRF. OS HOMO SAPIENS (HUMAN). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; PRIMATES. RN [1] RP SEQUENCE FROM N.A. RC TISSUE=PLACENTA; RM 94208062 RA AKIRA S., NISHIO Y., INOUE M., WANG X.J., SHI W., MATSUSAKA T., RA YOSHIDA K., SUDO T., NARUTO M., KISHIMOTO T.; RL CELL 77:63-71(1994). CC -!- FUNCTION: TRANSCRIPTION FACTOR THAT BINDS TO THE INTERLEUKIN-6 CC (IL-6)-RESPONSIVE ELEMENTS IDENTIFIED IN THE PROMOTERS OF VARIOUS CC ACUTE-PHASE PROTEIN GENES. CC -!- SUBCELLULAR LOCATION: NUCLEAR; TRANSLOCATED INTO THE NUCLEUS IN CC RESPONSE TO IL-6, IL-11, CTNF, LIF AND OSM. CC -!- PTM: TYROSINE PHOSPHORYLATED. CC -!- SIMILARITY: TO P91. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L29277; HSAPRF. DR MIM; 102582; 11TH EDITION. KW TRANSCRIPTION REGULATION; DNA-BINDING; NUCLEAR PROTEIN; KW PHOSPHORYLATION. SQ SEQUENCE 770 AA; 88052 MW; 3127673 CN; MAQWNQLQQL DTRYLEQLHQ LYSDSFPMEL RQFLAPWIES QDWAYAASKE SHATLVFHNL LGEIDQQYSR FLQESNVLYQ HNLRRIKQFL QSRYLEKPME IARIVARCLW EESRLLQTAA TAAQQGGQAN HPTAAVVTEK QQMLEQHLQD VRKRVQDLEQ KMKVVENLQD DFDFNYKTLK SQGDMQDLNG NNQSVTRQKM QQLEQMLTAL DQMRRSIVSE LAGLLSAMEY VQKTLTDEEL ADWKRRQQIA CIGGPPNICL DRLENWITSL AESQLQTRQQ IKKLEELHQK VSYKGDPIVQ HRPMLEERIV ELFRNLMKSA FVVERQPCMP MHPDRPLVIK TGVQFTTKVR LLVKFPELNY QLKIKVCIDK DSGDVAALRG SRKFNILGTN TKVMNMEESN NGSLSAEFKH LTLREQRCGN GGRANCDASL IVTEELHLIT FETEVYHQGL KIDLETHSLS VVVISNICQM PNAWASILWY NMLTNNPKNV NFFTKPPIGT WDQVAEVLSW QFSSTTKRGL SIEQLTTLAE KLLGPGVNYS GCQITWANFC KENMAGKGFS YWVWLDNIID LVKKYILALW NEGYIMGFIS KERERAILST KPPGTFLLRF SESSKEGGVT FTWVEKDISG KTQIQSVEPY TKQQLNNMSF AEIIMGYKIM DATNILLSPL VYLYPDIPKE EAFGKYCRPE SQEHPEADPG SAAPYLKTKF ICVTPTTCSN TIDLPMSPRA LDSLMQFGNN GEGAEPSAGG QFESLTFDME LTSECATSPM //