ID CYAA_HAEIN Reviewed; 843 AA. AC P40134; DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1995, sequence version 1. DT 11-JUL-2012, entry version 75. DE RecName: Full=Adenylate cyclase; DE EC=4.6.1.1; DE AltName: Full=ATP pyrophosphate-lyase; DE AltName: Full=Adenylyl cyclase; GN Name=cyaA; Synonyms=cya; OrderedLocusNames=HI_0604; OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd). OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales; OC Pasteurellaceae; Haemophilus. OX NCBI_TaxID=71421; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd; RX MEDLINE=94042886; PubMed=8226661; RA Dorocicz I.R., Williams P.M., Redfield R.J.; RT "The Haemophilus influenzae adenylate cyclase gene: cloning, sequence, RT and essential role in competence."; RL J. Bacteriol. 175:7142-7149(1993). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd; RX MEDLINE=95350630; PubMed=7542800; DOI=10.1126/science.7542800; RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., RA Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., RA Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., RA Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., RA Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., RA Venter J.C.; RT "Whole-genome random sequencing and assembly of Haemophilus influenzae RT Rd."; RL Science 269:496-512(1995). CC -!- FUNCTION: Plays an essential role in competence development. CC -!- CATALYTIC ACTIVITY: ATP = 3',5'-cyclic AMP + diphosphate. CC -!- SUBCELLULAR LOCATION: Cytoplasm. CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-1 family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L23824; AAC36855.1; -; Unassigned_DNA. DR EMBL; L42023; AAC22262.1; -; Genomic_DNA. DR PIR; A49922; A49922. DR RefSeq; NP_438762.1; NC_000907.1. DR GeneID; 950010; -. DR GenomeReviews; L42023_GR; HI_0604. DR KEGG; hin:HI0604; -. DR PATRIC; 20189787; VBIHaeInf48452_0628. DR eggNOG; COG3072; -. DR KO; K05851; -. DR OMA; LWQLYKG; -. DR ProtClustDB; PRK09450; -. DR BioCyc; HINF71421:HI_0604-MONOMER; -. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0004016; F:adenylate cyclase activity; IEA:EC. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0030420; P:establishment of competence for transformation; IEA:UniProtKB-KW. DR InterPro; IPR000274; Adenylate_cyclase_1. DR InterPro; IPR024686; Adenylate_cyclase_1_CS. DR InterPro; IPR024685; Adenylate_cyclase_1_N. DR Pfam; PF12633; Adenyl_cycl_N; 1. DR Pfam; PF01295; Adenylate_cycl; 1. DR PIRSF; PIRSF001444; Adenylate_cycl; 1. DR PROSITE; PS01092; ADENYLATE_CYCLASE_1_1; 1. DR PROSITE; PS01093; ADENYLATE_CYCLASE_1_2; 1. PE 3: Inferred from homology; KW ATP-binding; cAMP biosynthesis; Competence; Complete proteome; KW Cytoplasm; Lyase; Nucleotide-binding; Reference proteome. FT CHAIN 1 843 Adenylate cyclase. FT /FTId=PRO_0000195676. FT REGION 1 542 Catalytic (Potential). FT REGION 549 843 Regulatory (Potential). SQ SEQUENCE 843 AA; 97927 MW; B8C7BDFDFB07EEE7 CRC64; MECNLAQAKQ WVSALDQRRF ERALQGSGDA FQHVLAIVPL LLHLNHPQLP GYVIHAPSGI ASFLASDYQK KWLTNEYGIH YADHKPSTLK SAVNFHEVFP PILGVYVMGS FGSISQTSSS DLDTWICVRD GLSLDEYTLL TQKAKRISEW AMQFNVEINF YLMDQQRFRN EHYADPLTIE NSGSAQYMLL LDEFYRSAVR LAGKPLLWLH LWVENEKDYE KEVARLITEG EIDPNDWVDF GGLGQFSANE YFGASLWHLY KGIDSPYKSV LKILLLEAYS KEYPNTCLIA RTFKRDLLAG NTNPDHHFDP YIAILAKVTQ YLTALSEFKR LDFVHRCFYV KATEDFARYQ ANNWRIRYME ILAQEWGWSA ETVKHLNKRP FWKIKAVKEN HDNIMKFLML SYRNLVEFAR KHHIHSSVVP QDINILSRKL YTAFEELPGK VSLLNTQISH NLSEAHLTFV EVRGNKHFKD GWYLINQPIH HIMFSKERVI EYGESLNKLV SWAYFNHLLT EKTELSIFSK NVTLSTLQRF VTNLRQSFPS TIAKQPKNSD LLNQCEIRSL FIAINLTTDP TSKVEEVLTG ISSRDLFSFG SLEQSLVGSI DFTYRNVWNE IRTLHFEGQN AILLALKVLS NKIYRGVNRP DSIQVYCYSE RYRQDLRQLV MGLVNRCVSI QVGDIQQPCQ TSRLRVAGKN WQLFFEDRGI SLQEIGNESV CNEAESAVDF DEVLQTPIED GETNQESRRY PPEMDAFASE GFLQFFFEDN SDHSFNVYIL DESNHLEIYR HCDGEKDEKV REINQLYQNA KQEGDKNPYN IVQHNFNYPQ FYQLQNGKNG ISIVPFKFRQ MNK //