ID CYAA_HAEIN STANDARD; PRT; 843 AA. AC P40134; DT 01-FEB-1995 (Rel. 31, Created) DT 01-FEB-1995 (Rel. 31, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Adenylate cyclase (EC 4.6.1.1) (ATP pyrophosphate-lyase) (Adenylyl DE cyclase). GN CYAA OR CYA OR HI0604. OS Haemophilus influenzae. OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales; OC Pasteurellaceae; Haemophilus. OX NCBI_TaxID=727; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=Rd; RX MEDLINE=94042886; PubMed=8226661; RA Dorocicz I.R., Williams P.M., Redfield R.J.; RT "The Haemophilus influenzae adenylate cyclase gene: cloning, RT sequence, and essential role in competence."; RL J. Bacteriol. 175:7142-7149(1993). RN [2] RP SEQUENCE FROM N.A. RC STRAIN=Rd / KW20 / ATCC 51907; RX MEDLINE=95350630; PubMed=7542800; RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., RA McKenney K., Sutton G., Fitzhugh W., Fields C.A., Gocayne J.D., RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., RA Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., RA Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., RA Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., RA Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., RA Venter J.C.; RT "Whole-genome random sequencing and assembly of Haemophilus influenzae RT Rd."; RL Science 269:496-512(1995). CC -!- FUNCTION: Plays an essential role in competence development. CC -!- CATALYTIC ACTIVITY: ATP = 3',5'-cyclic AMP + diphosphate. CC -!- SUBCELLULAR LOCATION: Cytoplasmic. CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-1 family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L23824; AAC36855.1; -. DR EMBL; U32742; AAC22262.1; -. DR PIR; A49922; A49922. DR TIGR; HI0604; -. DR InterPro; IPR000274; Adenylt_cyclse_1. DR Pfam; PF01295; Adenylate_cycla; 1. DR PROSITE; PS01092; ADENYLATE_CYCLASE_1_1; 1. DR PROSITE; PS01093; ADENYLATE_CYCLASE_1_2; 1. KW Competence; cAMP biosynthesis; Lyase; Complete proteome. FT DOMAIN 1 542 CATALYTIC (POTENTIAL). FT DOMAIN 549 843 REGULATORY (POTENTIAL). SQ SEQUENCE 843 AA; 97926 MW; B8C7BDFDFB07EEE7 CRC64; MECNLAQAKQ WVSALDQRRF ERALQGSGDA FQHVLAIVPL LLHLNHPQLP GYVIHAPSGI ASFLASDYQK KWLTNEYGIH YADHKPSTLK SAVNFHEVFP PILGVYVMGS FGSISQTSSS DLDTWICVRD GLSLDEYTLL TQKAKRISEW AMQFNVEINF YLMDQQRFRN EHYADPLTIE NSGSAQYMLL LDEFYRSAVR LAGKPLLWLH LWVENEKDYE KEVARLITEG EIDPNDWVDF GGLGQFSANE YFGASLWHLY KGIDSPYKSV LKILLLEAYS KEYPNTCLIA RTFKRDLLAG NTNPDHHFDP YIAILAKVTQ YLTALSEFKR LDFVHRCFYV KATEDFARYQ ANNWRIRYME ILAQEWGWSA ETVKHLNKRP FWKIKAVKEN HDNIMKFLML SYRNLVEFAR KHHIHSSVVP QDINILSRKL YTAFEELPGK VSLLNTQISH NLSEAHLTFV EVRGNKHFKD GWYLINQPIH HIMFSKERVI EYGESLNKLV SWAYFNHLLT EKTELSIFSK NVTLSTLQRF VTNLRQSFPS TIAKQPKNSD LLNQCEIRSL FIAINLTTDP TSKVEEVLTG ISSRDLFSFG SLEQSLVGSI DFTYRNVWNE IRTLHFEGQN AILLALKVLS NKIYRGVNRP DSIQVYCYSE RYRQDLRQLV MGLVNRCVSI QVGDIQQPCQ TSRLRVAGKN WQLFFEDRGI SLQEIGNESV CNEAESAVDF DEVLQTPIED GETNQESRRY PPEMDAFASE GFLQFFFEDN SDHSFNVYIL DESNHLEIYR HCDGEKDEKV REINQLYQNA KQEGDKNPYN IVQHNFNYPQ FYQLQNGKNG ISIVPFKFRQ MNK //