ID   RGI1_YEAST              Reviewed;         161 AA.
AC   P40043; D3DLX2;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   13-NOV-2013, entry version 93.
DE   RecName: Full=Respiratory growth induced protein 1;
GN   Name=RGI1; OrderedLocusNames=YER067W;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204511 / S288c / AB972;
RX   PubMed=9169868;
RA   Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E.,
RA   Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E.,
RA   Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G.,
RA   Hunicke-Smith S., Hyman R.W., Kayser A., Komp C., Lashkari D., Lew H.,
RA   Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P.,
RA   Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T.,
RA   Smith V., Taylor P., Wei Y., Botstein D., Davis R.W.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome V.";
RL   Nature 387:78-81(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RG   Saccharomyces Genome Database;
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=17322287; DOI=10.1101/gr.6037607;
RA   Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA   Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A.,
RA   Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F.,
RA   Williamson J., Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G.,
RA   Kolodner R.D., LaBaer J.;
RT   "Approaching a complete repository of sequence-verified protein-
RT   encoding clones for Saccharomyces cerevisiae.";
RL   Genome Res. 17:536-543(2007).
RN   [4]
RP   INDUCTION.
RX   PubMed=10770760; DOI=10.1128/AAC.44.5.1255-1265.2000;
RA   Bammert G.F., Fostel J.M.;
RT   "Genome-wide expression patterns in Saccharomyces cerevisiae:
RT   comparison of drug treatments and genetic alterations affecting
RT   biosynthesis of ergosterol.";
RL   Antimicrob. Agents Chemother. 44:1255-1265(2000).
RN   [5]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A.,
RA   Dephoure N., O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
RN   [6]
RP   UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-68, AND MASS
RP   SPECTROMETRY.
RC   STRAIN=SUB592;
RX   PubMed=12872131; DOI=10.1038/nbt849;
RA   Peng J., Schwartz D., Elias J.E., Thoreen C.C., Cheng D.,
RA   Marsischky G., Roelofs J., Finley D., Gygi S.P.;
RT   "A proteomics approach to understanding protein ubiquitination.";
RL   Nat. Biotechnol. 21:921-926(2003).
RN   [7]
RP   INDUCTION.
RX   PubMed=15870279; DOI=10.1128/MCB.25.10.4075-4091.2005;
RA   Lai L.C., Kosorukoff A.L., Burke P.V., Kwast K.E.;
RT   "Dynamical remodeling of the transcriptome during short-term
RT   anaerobiosis in Saccharomyces cerevisiae: differential response and
RT   role of Msn2 and/or Msn4 and other factors in galactose and glucose
RT   media.";
RL   Mol. Cell. Biol. 25:4075-4091(2005).
RN   [8]
RP   INDUCTION.
RX   PubMed=18756096;
RA   Seo H.Y., Chang Y.J., Chung Y.J., Kim K.S.;
RT   "Proteomic analysis of recombinant Saccharomyces cerevisiae upon iron
RT   deficiency induced via human H-ferritin production.";
RL   J. Microbiol. Biotechnol. 18:1368-1376(2008).
RN   [9]
RP   X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 11-161, FUNCTION, AND
RP   SUBCELLULAR LOCATION.
RX   PubMed=20567505; DOI=10.1371/journal.pone.0011163;
RA   Domitrovic T., Kozlov G., Freire J.C., Masuda C.A.,
RA   da Silva Almeida M., Montero-Lomeli M., Atella G.C., Matta-Camacho E.,
RA   Gehring K., Kurtenbach E.;
RT   "Structural and functional study of YER067W, a new protein involved in
RT   yeast metabolism control and drug resistance.";
RL   PLoS ONE 5:E11163-E11163(2010).
CC   -!- FUNCTION: Involved in the control of energetic metabolism and
CC       significantly contribute to cell fitness, especially under
CC       respiratory growth conditions.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein.
CC   -!- INDUCTION: Up-regulated by a wide range of conditions, such as
CC       intracellular iron depletion, carbon source restriction, high
CC       temperature, high osmotic stress, cold stress, unfolded protein
CC       response, and high hydrostatic pressure. The promoter contains
CC       several binding sites for the stress response transcription
CC       factors MSN2, MSN4 and HSF1. Down-regulated when treated with
CC       different antifungal drugs from the azole class.
CC   -!- MISCELLANEOUS: Present with 8450 molecules/cell in log phase SD
CC       medium.
CC   -!- SIMILARITY: Belongs to the RGI1 family.
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DR   EMBL; U18813; AAB64603.1; -; Genomic_DNA.
DR   EMBL; AY692724; AAT92743.1; -; Genomic_DNA.
DR   EMBL; BK006939; DAA07726.1; -; Genomic_DNA.
DR   PIR; S50570; S50570.
DR   RefSeq; NP_010990.1; NM_001178958.1.
DR   PDB; 3BCY; X-ray; 1.70 A; A=11-161.
DR   PDBsum; 3BCY; -.
DR   ProteinModelPortal; P40043; -.
DR   SMR; P40043; 16-161.
DR   DIP; DIP-5346N; -.
DR   MINT; MINT-551142; -.
DR   STRING; 4932.YER067W; -.
DR   PaxDb; P40043; -.
DR   PeptideAtlas; P40043; -.
DR   EnsemblFungi; YER067W; YER067W; YER067W.
DR   GeneID; 856797; -.
DR   KEGG; sce:YER067W; -.
DR   CYGD; YER067w; -.
DR   SGD; S000000869; RGI1.
DR   eggNOG; NOG41208; -.
DR   GeneTree; ENSGT00390000011508; -.
DR   HOGENOM; HOG000000841; -.
DR   OMA; CTHEDAM; -.
DR   OrthoDB; EOG7GTTFM; -.
DR   BioCyc; YEAST:G3O-30241-MONOMER; -.
DR   EvolutionaryTrace; P40043; -.
DR   NextBio; 983038; -.
DR   Genevestigator; P40043; -.
DR   GO; GO:0071944; C:cell periphery; IDA:SGD.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006112; P:energy reserve metabolic process; IMP:SGD.
DR   InterPro; IPR022554; DUF2578.
DR   Pfam; PF10843; DUF2578; 1.
DR   ProDom; PD034538; DUF2578; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cell membrane; Complete proteome; Isopeptide bond;
KW   Membrane; Reference proteome; Ubl conjugation.
FT   CHAIN         1    161       Respiratory growth induced protein 1.
FT                                /FTId=PRO_0000202633.
FT   CROSSLNK     68     68       Glycyl lysine isopeptide (Lys-Gly)
FT                                (interchain with G-Cter in ubiquitin).
FT   STRAND       17     27
FT   HELIX        28     40
FT   STRAND       48     53
FT   HELIX        56     60
FT   TURN         61     64
FT   HELIX        66     68
FT   HELIX        78     90
FT   HELIX        92     99
FT   STRAND      108    114
FT   STRAND      116    129
FT   STRAND      132    145
FT   STRAND      149    159
SQ   SEQUENCE   161 AA;  18989 MW;  31C2929EBB19BF37 CRC64;
     MTKKDKKEVK VQTVTTEDGE TVKVFEDLQG FETFIANETE DDDFDHLHCK LNYYPPFVLH
     ESHEDPEKIS DAANSHSKKF VRHLHQHIEK HLLKDIKQAV RKPELKFHEK SKEETFDKIT
     WHYGEETEYH GRPFKIDVQV VCTHEDAMVF VDYKTHPVGA N
//