ID GDI1_YEAST STANDARD; PRT; 451 AA. AC P39958; DT 01-FEB-1995 (REL. 31, CREATED) DT 01-FEB-1995 (REL. 31, LAST SEQUENCE UPDATE) DT 01-FEB-1995 (REL. 31, LAST ANNOTATION UPDATE) DE SECRETORY PATHWAY GDP DISSOCIATION INHIBITOR. GN GDI1 OR SEC19 OR YER136W. OS SACCHAROMYCES CEREVISIAE (BAKER'S YEAST). OC EUKARYOTA; FUNGI; ASCOMYCOTA; HEMIASCOMYCETES; SACCHAROMYCETALES; OC SACCHAROMYCETACEAE; SACCHAROMYCES. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 94208542. RA GARRETT M.D., ZAHNER J.E., CHENEY C.M., NOVICK P.J.; RT "GDI1 encodes a GDP dissociation inhibitor that plays an essential RT role in the yeast secretory pathway."; RL EMBO J. 13:1718-1728(1994). RN [2] RP SEQUENCE FROM N.A. RC STRAIN=S288C / AB972; RA DIETRICH F.S., MULLIGAN J.T., HENNESSEY K.M., ALLEN E., ARAUJO R., RA AVILES E., BERNO A., BRENNAN T., CARPENTER J., CHEN E., CHERRY J.M., RA CHUNG E., DUNCAN M., GUZMAN E., HARTZELL G., HUNICKE-SMITH S., RA HYMAN R., KAYSER A., KOMP C., LASHKARI D., LEW H., LIN D., RA MOSEDALE D., NAKAHARA K., NAMATH A., NORGREN R., OEFNER P., OH C., RA PETEL F.X., ROBERTS D., SEHL P., SCHRAMM S., SHOGREN T., SMITH V., RA TAYLOR P., WEI Y., YELTON M., BOTSTEIN D., DAVIS R.W.; RL SUBMITTED (DEC-1994) TO EMBL/GENBANK/DDBJ DATA BANKS. CC -!- FUNCTION: REGULATES THE GDP/GTP EXCHANGE REACTION OF SEC4 BY CC INHIBITING THE DISSOCIATION OF GDP FROM IT, AND THE SUBSEQUENT CC BINDING OF GTP TO SEC4. PLAYS AN ESSENTIAL ROLE IN THE YEAST CC SECRETORY PATHWAY. CC -!- SIMILARITY: BELONGS TO THE TCD/MRS6 FAMILY OF GDP DISSOCIATION CC INHIBITOR. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; S69371; G546371; -. DR EMBL; U18916; G603375; -. DR PIR; S44446; S44446. DR SGD; L0000699; GDI1. DR PFAM; PF00996; GDI; 1. DR HSSP; P21856; 1GND. KW GTPASE ACTIVATION; PROTEIN TRANSPORT. SQ SEQUENCE 451 AA; 51206 MW; CCC43D4B CRC32; MDQETIDTDY DVIVLGTGIT ECILSGLLSV DGKKVLHIDK QDHYGGEAAS VTLSQLYEKF KQNPISKEER ESKFGKDRDW NVDLIPKFLM ANGELTNILI HTDVTRYVDF KQVSGSYVFK QGKIYKVPAN EIEAISSPLM GIFEKRRMKK FLEWISSYKE DDLSTHQGLD LDKNTMDEVY YKFGLGNSTK EFIGHAMALW TNDDYLQQPA RPSFERILLY CQSVARYGKS PYLYPMYGLG ELPQGFARLS AIYGGTYMLD TPIDEVLYKK DTGKFEGVKT KLGTFKAPLV IADPTYFPEK CKSTGQRVIR AICILNHPVP NTSNADSLQI IIPQSQLGRK SDIYVAIVSD AHNVCSKGHY LAIISTIIET DKPHIELEPA FKLLGPIEEK FMGIAELFEP REDGSKDNIY LSRSYDASSH FESMTDDVKD IYFRVTGHPL VLKQRQEQEK Q //