ID GDI1_YEAST STANDARD; PRT; 451 AA. AC P39958; DT 01-FEB-1995 (REL. 31, CREATED) DT 01-FEB-1995 (REL. 31, LAST SEQUENCE UPDATE) DT 01-FEB-1995 (REL. 31, LAST ANNOTATION UPDATE) DE SECRETORY PATHWAY GDP DISSOCIATION INHIBITOR. GN GDI1 OR SEC19 OR YER136W. OS SACCHAROMYCES CEREVISIAE (BAKER'S YEAST). OC EUKARYOTA; FUNGI; ASCOMYCOTINA; HEMIASCOMYCETES. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 94208542. RA GARRETT M.D., ZAHNER J.E., CHENEY C.M., NOVICK P.J.; RL EMBO J. 13:1718-1728(1994). RN [2] RP SEQUENCE FROM N.A. RC STRAIN=S288C / AB972; RA DIETRICH F.S., MULLIGAN J.T., HENNESSEY K.M., ALLEN E., ARAUJO R., RA AVILES E., BERNO A., BRENNAN T., CARPENTER J., CHEN E., CHERRY J.M., RA CHUNG E., DUNCAN M., GUZMAN E., HARTZELL G., HUNICKE-SMITH S., RA HYMAN R., KAYSER A., KOMP C., LASHKARI D., LEW H., LIN D., RA MOSEDALE D., NAKAHARA K., NAMATH A., NORGREN R., OEFNER P., OH C., RA PETEL F.X., ROBERTS D., SEHL P., SCHRAMM S., SHOGREN T., SMITH V., RA TAYLOR P., WEI Y., YELTON M., BOTSTEIN D., DAVIS R.W.; RL SUBMITTED (DEC-1994) TO EMBL/GENBANK/DDBJ DATA BANKS. CC -!- FUNCTION: REGULATES THE GDP/GTP EXCHANGE REACTION OF SEC4 BY CC INHIBITING THE DISSOCIATION OF GDP FROM IT, AND THE SUBSEQUENT CC BINDING OF GTP TO SEC4. PLAYS AN ESSENTIAL ROLE IN THE YEAST CC SECRETORY PATHWAY. CC -!- SIMILARITY: BELONGS TO THE TCD/MRS6 FAMILY OF GDP DISSOCIATION CC INHIBITOR. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; S69371; G546371; -. DR EMBL; U18916; G603375; -. DR PIR; S44446; S44446. DR SGD; L0000699; GDI1. KW GTPASE ACTIVATION; PROTEIN TRANSPORT. SQ SEQUENCE 451 AA; 51206 MW; CCC43D4B CRC32; MDQETIDTDY DVIVLGTGIT ECILSGLLSV DGKKVLHIDK QDHYGGEAAS VTLSQLYEKF KQNPISKEER ESKFGKDRDW NVDLIPKFLM ANGELTNILI HTDVTRYVDF KQVSGSYVFK QGKIYKVPAN EIEAISSPLM GIFEKRRMKK FLEWISSYKE DDLSTHQGLD LDKNTMDEVY YKFGLGNSTK EFIGHAMALW TNDDYLQQPA RPSFERILLY CQSVARYGKS PYLYPMYGLG ELPQGFARLS AIYGGTYMLD TPIDEVLYKK DTGKFEGVKT KLGTFKAPLV IADPTYFPEK CKSTGQRVIR AICILNHPVP NTSNADSLQI IIPQSQLGRK SDIYVAIVSD AHNVCSKGHY LAIISTIIET DKPHIELEPA FKLLGPIEEK FMGIAELFEP REDGSKDNIY LSRSYDASSH FESMTDDVKD IYFRVTGHPL VLKQRQEQEK Q //