ID GDI1_YEAST STANDARD; PRT; 451 AA. AC P39958; DT 01-FEB-1995 (Rel. 31, Created) DT 01-FEB-1995 (Rel. 31, Last sequence update) DT 01-FEB-2005 (Rel. 46, Last annotation update) DE Secretory pathway GDP dissociation inhibitor. GN Name=GDI1; Synonyms=SEC19; OrderedLocusNames=YER136W; OS Saccharomyces cerevisiae (Baker's yeast). OC Eukaryota; Fungi; Ascomycota; Saccharomycotina; Saccharomycetes; OC Saccharomycetales; Saccharomycetaceae; Saccharomyces. OX NCBI_TaxID=4932; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=94208542; PubMed=8157010; RA Garrett M.D., Zahner J.E., Cheney C.M., Novick P.J.; RT "GDI1 encodes a GDP dissociation inhibitor that plays an essential RT role in the yeast secretory pathway."; RL EMBO J. 13:1718-1728(1994). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=S288c / AB972; RX MEDLINE=97313264; PubMed=9169868; RA Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., RA Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., RA Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., RA Hunicke-Smith S., Hyman R.W., Kayser A., Komp C., Lashkari D., Lew H., RA Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., RA Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., RA Smith V., Taylor P., Wei Y., Botstein D., Davis R.W.; RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome V."; RL Nature 387:78-81(1997). CC -!- FUNCTION: Regulates the GDP/GTP exchange reaction of SEC4 by CC inhibiting the dissociation of GDP from it, and the subsequent CC binding of GTP to SEC4. Plays an essential role in the yeast CC secretory pathway. CC -!- SIMILARITY: Belongs to the Rab GDI family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; S69371; AAB30540.1; -. DR EMBL; U18916; AAC03234.1; -. DR PIR; S44446; S44446. DR HSSP; P21856; 1D5T. DR IntAct; P39958; -. DR GermOnline; 139215; -. DR SGD; S000000938; GDI1. DR GO; GO:0005624; C:membrane fraction; IDA. DR GO; GO:0005625; C:soluble fraction; IDA. DR GO; GO:0005093; F:RAB GDP-dissociation inhibitor activity; IDA. DR GO; GO:0016192; P:vesicle-mediated transport; IMP. DR InterPro; IPR002005; Rab_GDI_REP. DR InterPro; IPR000806; RabGDI. DR Pfam; PF00996; GDI; 1. DR PRINTS; PR00891; RABGDIREP. KW Complete proteome; GTPase activation; Protein transport. SQ SEQUENCE 451 AA; 51206 MW; 48CF8D45FC031772 CRC64; MDQETIDTDY DVIVLGTGIT ECILSGLLSV DGKKVLHIDK QDHYGGEAAS VTLSQLYEKF KQNPISKEER ESKFGKDRDW NVDLIPKFLM ANGELTNILI HTDVTRYVDF KQVSGSYVFK QGKIYKVPAN EIEAISSPLM GIFEKRRMKK FLEWISSYKE DDLSTHQGLD LDKNTMDEVY YKFGLGNSTK EFIGHAMALW TNDDYLQQPA RPSFERILLY CQSVARYGKS PYLYPMYGLG ELPQGFARLS AIYGGTYMLD TPIDEVLYKK DTGKFEGVKT KLGTFKAPLV IADPTYFPEK CKSTGQRVIR AICILNHPVP NTSNADSLQI IIPQSQLGRK SDIYVAIVSD AHNVCSKGHY LAIISTIIET DKPHIELEPA FKLLGPIEEK FMGIAELFEP REDGSKDNIY LSRSYDASSH FESMTDDVKD IYFRVTGHPL VLKQRQEQEK Q //