ID MBP1_YEAST STANDARD; PRT; 833 AA. AC P39678; DT 01-FEB-1995 (REL. 31, CREATED) DT 01-FEB-1995 (REL. 31, LAST SEQUENCE UPDATE) DT 15-DEC-1998 (REL. 37, LAST ANNOTATION UPDATE) DE TRANSCRIPTION FACTOR MBP1 (MBF SUBUNIT P120). GN MBP1 OR YDL056W. OS SACCHAROMYCES CEREVISIAE (BAKER'S YEAST). OC EUKARYOTA; FUNGI; ASCOMYCOTA; HEMIASCOMYCETES; SACCHAROMYCETALES; OC SACCHAROMYCETACEAE; SACCHAROMYCES. RN [1] RP SEQUENCE FROM N.A., AND SEQUENCE OF 372-387. RC STRAIN=K1107; RX MEDLINE; 93383264. RA KOCH C., MOLL T., NEUBERG M., AHORN H., NASMYTH K.; RT "A role for the transcription factors Mbp1 and Swi4 in progression RT from G1 to S phase."; RL SCIENCE 261:1551-1557(1993). RN [2] RP SEQUENCE FROM N.A. RA BLOECKER H., BRANDT P.; RL SUBMITTED (JUL-1996) TO EMBL/GENBANK/DDBJ DATA BANKS. RN [3] RP SEQUENCE OF 460-833 FROM N.A. RA BENTON B.K., PLUMP S.D., ROOS J., LENNARZ W.J., CROSS F.R.; RL SUBMITTED (JAN-1995) TO EMBL/GENBANK/DDBJ DATA BANKS. RN [4] RP X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 1-100. RX MEDLINE; 97446148. RA TAYLOR I.A., TREIBER M.K., OLIVI L., SMERDON S.J.; RT "The X-ray structure of the DNA-binding domain from the Saccharomyces RT cerevisiae cell-cycle transcription factor Mbp1 at 2.1-A RT resolution."; RL J. MOL. BIOL. 272:1-8(1997). CC -!- FUNCTION: BINDS TO MCB ELEMENTS (MLU I CELL CYCLE BOX) FOUND IN CC THE PROMOTER OF MOST DNA SYNTHESIS GENES. TRANSCRIPTIONAL CC ACTIVATION BY MBF HAS AN IMPORTANT ROLE IN THE TRANSITION FROM G1 CC TO S PHASE. IT MAY HAVE A DUAL ROLE IN THAT IT BEHAVES AS AN CC ACTIVATOR OF TRANSCRIPTION AT THE G1-S BOUNDARY AND AS A REPRESSOR CC DURING OTHER STAGES OF THE CELL CYCLE. CC -!- SUBUNIT: MBF CONTAINS SWI6 AND MBP1. CC -!- SUBCELLULAR LOCATION: NUCLEAR. CC -!- SIMILARITY: CONTAINS 2 ANK REPEATS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X74158; G402793; -. DR EMBL; Z74104; E253002; -. DR EMBL; U19608; G639493; -. DR PIR; A47528; A47528. DR PIR; S37404; S37404. DR PDB; 1MB1; 29-JUL-98. DR SGD; L0001032; MBP1. DR PFAM; PF00023; ank; 2. KW TRANSCRIPTION REGULATION; ACTIVATOR; NUCLEAR PROTEIN; DNA-BINDING; KW ANK REPEAT; REPEAT; 3D-STRUCTURE. FT DNA_BIND 1 94 FT DOMAIN 388 538 2 X ANK MOTIF REPEATS. FT REPEAT 388 420 ANK MOTIF 1. FT REPEAT 506 538 ANK MOTIF 2. SQ SEQUENCE 833 AA; 93907 MW; 20FAB3BD CRC32; MSNQIYSARY SGVDVYEFIH STGSIMKRKK DDWVNATHIL KAANFAKAKR TRILEKEVLK ETHEKVQGGF GKYQGTWVPL NIAKQLAEKF SVYDQLKPLF DFTQTDGSAS PPPAPKHHHA SKVDRKKAIR SASTSAIMET KRNNKKAEEN QFQSSKILGN PTAAPRKRGR PVGSTRGSRR KLGVNLQRSQ SDMGFPRPAI PNSSISTTQL PSIRSTMGPQ SPTLGILEEE RHDSRQQQPQ QNNSAQFKEI DLEDGLSSDV EPSQQLQQVF NQNTGFVPQQ QSSLIQTQQT ESMATSVSSS PSLPTSPGDF ADSNPFEERF PGGGTSPIIS MIPRYPVTSR PQTSDINDKV NKYLSKLVDY FISNEMKSNK SLPQVLLHPP PHSAPYIDAP IDPELHTAFH WACSMGNLPI AEALYEAGTS IRSTNSQGQT PLMRSSLFHN SYTRRTFPRI FQLLHETVFD IDSQSQTVIH HIVKRKSTTP SAVYYLDVVL SKIKDFSPQY RIELLLNTQD KNGDTALHIA SKNGDVVFFN TLVKMGALTT ISNKEGLTAN EIMNQQYEQM MIQNGTNQHV NSSNTDLNIH VNTNNIETKN DVNSMVIMSP VSPSDYITYP SQIATNISRN IPNVVNSMKQ MASIYNDLHE QHDNEIKSLQ KTLKSISKTK IQVSLKTLEV LKESSKDENG EAQTNDDFEI LSRLQEQNTK KLRKRLIRYK RLIKQKLEYR QTVLLNKLIE DETQATTNNT VEKDNNTLER LELAQELTML QLQRKNKLSS LVKKFEDNAK IHKYRRIIRE GTEMNIEEVD SSLDVILQTL IANNNKNKGA EQIITISNAN SHA //