ID MBP1_YEAST STANDARD; PRT; 833 AA. AC P39678; DT 01-FEB-1995 (REL. 31, CREATED) DT 01-FEB-1995 (REL. 31, LAST SEQUENCE UPDATE) DT 01-NOV-1995 (REL. 32, LAST ANNOTATION UPDATE) DE TRANSCRIPTION FACTOR MBP1 (MBF SUBUNIT P120). GN MBP1. OS SACCHAROMYCES CEREVISIAE (BAKER'S YEAST). OC EUKARYOTA; FUNGI; ASCOMYCOTINA; HEMIASCOMYCETES. RN [1] RP SEQUENCE FROM N.A., AND SEQUENCE OF 372-387. RC STRAIN=K1107; RX MEDLINE; 93383264. RA KOCH C., MOLL T., NEUBERG M., AHORN H., NASMYTH K.; RL SCIENCE 261:1551-1557(1993). RN [2] RP SEQUENCE OF 460-833 FROM N.A. RA BENTON B.K., PLUMP S.D., ROOS J., LENNARZ W.J., CROSS F.R.; RL SUBMITTED (JAN-1995) TO EMBL/GENBANK/DDBJ DATA BANKS. CC -!- FUNCTION: BINDS TO MCB ELEMENTS (MLU I CELL CYCLE BOX) FOUND IN CC THE PROMOTER OF MOST DNA SYNTHESIS GENES. TRANSCRIPTIONAL CC ACTIVATION BY MBF HAS AN IMPORTANT ROLE IN THE TRANSITION FROM G1 CC TO S PHASE. IT MAY HAVE A DUAL ROLE IN THAT IT BEHAVES AS AN CC ACTIVATOR OF TRANSRIPTION AT THE G1-S BOUNDARY AND AS A REPRESSOR CC DURING OTHER STAGES OF THE CELL CYCLE. CC -!- SUBUNIT: MBF CONTAINS SWI6 AND MBP1. CC -!- SUBCELLULAR LOCATION: NUCLEAR. CC -!- SIMILARITY: CONTAINS 2 ANK REPEATS. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X74158; X74158. DR EMBL; U19608; U19608. DR PIR; A47528; A47528. DR PIR; S37404; S37404. DR LISTA; SC00580; MBP1. DR SGD; L0001032; MBP1. KW TRANSCRIPTION REGULATION; ACTIVATOR; NUCLEAR PROTEIN; DNA-BINDING; KW ANK REPEAT; REPEAT. FT DNA_BIND 1 94 POTENTIAL. FT DOMAIN 388 538 2 X ANK MOTIF REPEATS. FT REPEAT 388 420 ANK MOTIF 1. FT REPEAT 506 538 ANK MOTIF 2 SQ SEQUENCE 833 AA; 93907 MW; 3539915 CN; MSNQIYSARY SGVDVYEFIH STGSIMKRKK DDWVNATHIL KAANFAKAKR TRILEKEVLK ETHEKVQGGF GKYQGTWVPL NIAKQLAEKF SVYDQLKPLF DFTQTDGSAS PPPAPKHHHA SKVDRKKAIR SASTSAIMET KRNNKKAEEN QFQSSKILGN PTAAPRKRGR PVGSTRGSRR KLGVNLQRSQ SDMGFPRPAI PNSSISTTQL PSIRSTMGPQ SPTLGILEEE RHDSRQQQPQ QNNSAQFKEI DLEDGLSSDV EPSQQLQQVF NQNTGFVPQQ QSSLIQTQQT ESMATSVSSS PSLPTSPGDF ADSNPFEERF PGGGTSPIIS MIPRYPVTSR PQTSDINDKV NKYLSKLVDY FISNEMKSNK SLPQVLLHPP PHSAPYIDAP IDPELHTAFH WACSMGNLPI AEALYEAGTS IRSTNSQGQT PLMRSSLFHN SYTRRTFPRI FQLLHETVFD IDSQSQTVIH HIVKRKSTTP SAVYYLDVVL SKIKDFSPQY RIELLLNTQD KNGDTALHIA SKNGDVVFFN TLVKMGALTT ISNKEGLTAN EIMNQQYEQM MIQNGTNQHV NSSNTDLNIH VNTNNIETKN DVNSMVIMSP VSPSDYITYP SQIATNISRN IPNVVNSMKQ MASIYNDLHE QHDNEIKSLQ KTLKSISKTK IQVSLKTLEV LKESSKDENG EAQTNDDFEI LSRLQEQNTK KLRKRLIRYK RLIKQKLEYR QTVLLNKLIE DETQATTNNT VEKDNNTLER LELAQELTML QLQRKNKLSS LVKKFEDNAK IHKYRRIIRE GTEMNIEEVD SSLDVILQTL IANNNKNKGA EQIITISNAN SHA //