ID TEM1_YEAST STANDARD; PRT; 245 AA. AC P38987; DT 01-FEB-1995 (REL. 31, CREATED) DT 01-FEB-1995 (REL. 31, LAST SEQUENCE UPDATE) DT 01-OCT-1996 (REL. 34, LAST ANNOTATION UPDATE) DE TEM1 PROTEIN. GN TEM1 OR YML064C. OS SACCHAROMYCES CEREVISIAE (BAKER'S YEAST). OC EUKARYOTA; FUNGI; ASCOMYCOTA; HEMIASCOMYCETES; SACCHAROMYCETALES; OC SACCHAROMYCETACEAE; SACCHAROMYCES. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 95021277. RA SHIRAYAMA M., MATSUI Y., TOH-E A.; RT "The yeast TEM1 gene, which encodes a GTP-binding protein, is RT involved in termination of M phase."; RL MOL. CELL. BIOL. 14:7476-7482(1994). RN [2] RP SEQUENCE FROM N.A. RC STRAIN=S288C / AB972; RA BOWMAN S., CHURCHER C., BARRELL B.G., RAJANDREAM M.A.; RL SUBMITTED (AUG-1994) TO EMBL/GENBANK/DDBJ DATA BANKS. CC -!- FUNCTION: GTP-BINDING PROTEIN INVOLVED IN TERMINATION OF M PHASE. CC MAY PLAY A ROLE IN TRIGGERING THE DEGRADATION OF G2 CYCLIN TO CC INACTIVATE M-PHASE PROMOTING FACTOR AT THE TERMINATION OF MITOSIS. CC ACTS UPSTREAM OF CDC15 KINASE AND MAY BE REQUIRED TO ACTIVATE THE CC CDC15 PROTEIN KINASE PATHWAY. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; D38172; G537606; -. DR EMBL; Z38114; G558411; -. DR PIR; S48334; S48334. DR SGD; L0002282; TEM1. DR PFAM; PF00071; ras; 1. KW GTP-BINDING; MITOSIS. FT NP_BIND 27 34 GTP (BY SIMILARITY). FT NP_BIND 75 79 GTP (BY SIMILARITY). FT NP_BIND 132 135 GTP (BY SIMILARITY). SQ SEQUENCE 245 AA; 27296 MW; 60626076 CRC32; MATPSTGANN SIPAVRNQVE VQVGLVGDAQ VGKTSLMVKY VQNIYDKEYT QTLGVNFLKR KVSIRSTDII FSIMDLGGQR EFINMLPIAT VGSSVIIFLF DLTRPETLSS IKEWYRQAYG LNDSAIPILV GTKYDLLIDL DPEYQEQISR TSMKYAQVMN APLIFCSTAK SINIQKIFKI ALAKIFNLTL TIPEINEIGD PLLIYKHLGG QQHRHHNKSQ DRKSHNIRKP SSSPSSKAPS PGVNT //