ID TEM1_YEAST STANDARD; PRT; 245 AA. AC P38987; DT 01-FEB-1995 (Rel. 31, Created) DT 01-FEB-1995 (Rel. 31, Last sequence update) DT 01-OCT-1996 (Rel. 34, Last annotation update) DE TEM1 protein. GN TEM1 OR YML064C. OS Saccharomyces cerevisiae (Baker's yeast). OC Eukaryota; Fungi; Ascomycota; Saccharomycotina; Saccharomycetes; OC Saccharomycetales; Saccharomycetaceae; Saccharomyces. OX NCBI_TaxID=4932; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=95021277; PubMed=7935462; RA Shirayama M., Matsui Y., Toh-E A.; RT "The yeast TEM1 gene, which encodes a GTP-binding protein, is RT involved in termination of M phase."; RL Mol. Cell. Biol. 14:7476-7482(1994). RN [2] RP SEQUENCE FROM N.A. RC STRAIN=S288c / AB972; RA Bowman S., Churcher C., Barrell B.G., Rajandream M.A.; RL Submitted (AUG-1994) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: GTP-BINDING PROTEIN INVOLVED IN TERMINATION OF M PHASE. CC MAY PLAY A ROLE IN TRIGGERING THE DEGRADATION OF G2 CYCLIN TO CC INACTIVATE M-PHASE PROMOTING FACTOR AT THE TERMINATION OF MITOSIS. CC ACTS UPSTREAM OF CDC15 KINASE AND MAY BE REQUIRED TO ACTIVATE THE CC CDC15 PROTEIN KINASE PATHWAY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; D38172; BAA07371.1; -. DR EMBL; Z38114; CAA86257.1; -. DR PIR; S48334; S48334. DR SGD; S0004529; TEM1. DR InterPro; IPR001806; Ras_trnsfrmng. DR InterPro; IPR005225; Small_GTP. DR InterPro; IPR003575; Small_GTPase. DR Pfam; PF00071; ras; 1. DR SMART; SM00010; small_GTPase; 1. DR TIGRFAMs; TIGR00231; small_GTP; 1. KW GTP-binding; Mitosis. FT NP_BIND 27 34 GTP (BY SIMILARITY). FT NP_BIND 75 79 GTP (BY SIMILARITY). FT NP_BIND 132 135 GTP (BY SIMILARITY). SQ SEQUENCE 245 AA; 27296 MW; F650C8946A03707C CRC64; MATPSTGANN SIPAVRNQVE VQVGLVGDAQ VGKTSLMVKY VQNIYDKEYT QTLGVNFLKR KVSIRSTDII FSIMDLGGQR EFINMLPIAT VGSSVIIFLF DLTRPETLSS IKEWYRQAYG LNDSAIPILV GTKYDLLIDL DPEYQEQISR TSMKYAQVMN APLIFCSTAK SINIQKIFKI ALAKIFNLTL TIPEINEIGD PLLIYKHLGG QQHRHHNKSQ DRKSHNIRKP SSSPSSKAPS PGVNT //