ID   TEM1_YEAST              Reviewed;         245 AA.
AC   P38987; D6VZA9;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   29-MAY-2013, entry version 109.
DE   RecName: Full=Protein TEM1;
GN   Name=TEM1; OrderedLocusNames=YML064C;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7935462;
RA   Shirayama M., Matsui Y., Toh-e A.;
RT   "The yeast TEM1 gene, which encodes a GTP-binding protein, is involved
RT   in termination of M phase.";
RL   Mol. Cell. Biol. 14:7476-7482(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204511 / S288c / AB972;
RX   PubMed=9169872;
RA   Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T.,
RA   Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S.,
RA   Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A.,
RA   Rice P., Skelton J., Walsh S.V., Whitehead S., Barrell B.G.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome
RT   XIII.";
RL   Nature 387:90-93(1997).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RG   Saccharomyces Genome Database;
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=17322287; DOI=10.1101/gr.6037607;
RA   Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA   Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A.,
RA   Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F.,
RA   Williamson J., Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G.,
RA   Kolodner R.D., LaBaer J.;
RT   "Approaching a complete repository of sequence-verified protein-
RT   encoding clones for Saccharomyces cerevisiae.";
RL   Genome Res. 17:536-543(2007).
RN   [5]
RP   FUNCTION, AND INTERACTION WITH AMN1 AND CDC15.
RX   PubMed=12628189; DOI=10.1016/S0092-8674(03)00121-1;
RA   Wang Y., Shirogane T., Liu D., Harper J.W., Elledge S.J.;
RT   "Exit from exit: resetting the cell cycle through Amn1 inhibition of G
RT   protein signaling.";
RL   Cell 112:697-709(2003).
RN   [6]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A.,
RA   Dephoure N., O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
CC   -!- FUNCTION: GTP-binding protein involved in termination of M phase.
CC       May play a role in triggering the degradation of G2 cyclin to
CC       inactivate M-phase promoting factor at the termination of mitosis.
CC       Acts upstream of CDC15 kinase and may be required to activate the
CC       CDC15 protein kinase pathway.
CC   -!- SUBUNIT: Interacts with CDC15 and AMN1. AMN1 and CDC15 compete for
CC       association with TEM1.
CC   -!- INTERACTION:
CC       P38285:AMN1; NbExp=6; IntAct=EBI-19113, EBI-20853;
CC       P47113:BFA1; NbExp=2; IntAct=EBI-19113, EBI-3586;
CC       P26448:BUB2; NbExp=2; IntAct=EBI-19113, EBI-3824;
CC       P27636:CDC15; NbExp=6; IntAct=EBI-19113, EBI-4200;
CC   -!- MISCELLANEOUS: Present with 573 molecules/cell in log phase SD
CC       medium.
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DR   EMBL; D38172; BAA07371.1; -; Genomic_DNA.
DR   EMBL; Z38114; CAA86257.1; -; Genomic_DNA.
DR   EMBL; AY557980; AAS56306.1; -; Genomic_DNA.
DR   EMBL; BK006946; DAA09833.1; -; Genomic_DNA.
DR   PIR; S48334; S48334.
DR   RefSeq; NP_013647.1; NM_001182423.1.
DR   ProteinModelPortal; P38987; -.
DR   SMR; P38987; 19-202.
DR   DIP; DIP-1691N; -.
DR   IntAct; P38987; 87.
DR   MINT; MINT-383751; -.
DR   STRING; 4932.YML064C; -.
DR   PaxDb; P38987; -.
DR   PeptideAtlas; P38987; -.
DR   EnsemblFungi; YML064C; YML064C; YML064C.
DR   GeneID; 854938; -.
DR   KEGG; sce:YML064C; -.
DR   CYGD; YML064c; -.
DR   SGD; S000004529; TEM1.
DR   eggNOG; COG1100; -.
DR   HOGENOM; HOG000216335; -.
DR   KO; K06682; -.
DR   OMA; DSQIGKT; -.
DR   OrthoDB; EOG4C5GTN; -.
DR   BioCyc; YEAST:G3O-32659-MONOMER; -.
DR   NextBio; 977983; -.
DR   Genevestigator; P38987; -.
DR   GermOnline; YML064C; Saccharomyces cerevisiae.
DR   GO; GO:0005816; C:spindle pole body; IDA:SGD.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IDA:SGD.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007067; P:mitosis; IEA:UniProtKB-KW.
DR   GO; GO:0007096; P:regulation of exit from mitosis; TAS:SGD.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   InterPro; IPR017231; Small_GTPase_Tem1.
DR   Pfam; PF00071; Ras; 1.
DR   PIRSF; PIRSF037527; Small_GTPase_Tem1; 1.
DR   PRINTS; PR00449; RASTRNSFRMNG.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51419; RAB; 1.
PE   1: Evidence at protein level;
KW   Cell cycle; Cell division; Complete proteome; GTP-binding; Mitosis;
KW   Nucleotide-binding; Reference proteome.
FT   CHAIN         1    245       Protein TEM1.
FT                                /FTId=PRO_0000122466.
FT   NP_BIND      27     34       GTP (By similarity).
FT   NP_BIND      75     79       GTP (By similarity).
FT   NP_BIND     132    135       GTP (By similarity).
FT   REGION       16    244       Small GTPase-like.
SQ   SEQUENCE   245 AA;  27296 MW;  F650C8946A03707C CRC64;
     MATPSTGANN SIPAVRNQVE VQVGLVGDAQ VGKTSLMVKY VQNIYDKEYT QTLGVNFLKR
     KVSIRSTDII FSIMDLGGQR EFINMLPIAT VGSSVIIFLF DLTRPETLSS IKEWYRQAYG
     LNDSAIPILV GTKYDLLIDL DPEYQEQISR TSMKYAQVMN APLIFCSTAK SINIQKIFKI
     ALAKIFNLTL TIPEINEIGD PLLIYKHLGG QQHRHHNKSQ DRKSHNIRKP SSSPSSKAPS
     PGVNT
//