ID PRCD_YEAST STANDARD; PRT; 215 AA. AC P38624; DT 01-OCT-1994 (REL. 30, CREATED) DT 01-NOV-1995 (REL. 32, LAST SEQUENCE UPDATE) DT 01-NOV-1995 (REL. 32, LAST ANNOTATION UPDATE) DE PROTEASOME COMPONENT PRE3 PRECURSOR (EC 3.4.99.46) (MACROPAIN SUBUNIT DE PRE3) (PROTEINASE YSCE SUBUNIT PRE3) (MULTICATALYTIC ENDOPEPTIDASE DE COMPLEX SUBUNIT PRE3). GN PRE3 OR YJL001W. OS SACCHAROMYCES CEREVISIAE (BAKER'S YEAST). OC EUKARYOTA; FUNGI; ASCOMYCOTINA; HEMIASCOMYCETES. RN [1] RP SEQUENCE FROM N.A. RC STRAIN=S288C; RX MEDLINE; 94185793. RA ENENKEL C., LEHMANN H., KIPPER J., GUECKEL R., HILT W., WOLF D.H.; RL FEBS LETT. 341:193-196(1994). RN [2] RP REVISIONS TO N-TERMINAL. RA CHEN P., HOCHSTRASSER M.; RL EMBO J. 14:2620-2630(1995). RN [3] RP SEQUENCE FROM N.A. RC STRAIN=S288C / FY1679; RA DE HAAN M., SMITS P.H.M., GRIVELL L.A.; RL SUBMITTED (MAY-1995) TO EMBL/GENBANK/DDBJ DATA BANKS. CC -!- FUNCTION: THE PROTEASOME IS A MULTICATALYTIC PROTEINASE COMPLEX CC WHICH IS CHARACTERIZED BY ITS ABILITY TO CLEAVE PEPTIDES WITH CC ARG, PHE, TYR, LEU, AND GLU ADJACENT TO THE LEAVING GROUP AT CC NEUTRAL OR SLIGHTLY BASIC PH. THE PROTEASOME HAS AN ATP-DEPENDENT CC PROTEOLYTIC ACTIVITY. PRE3 AND PRE4 ARE NECESSARY FOR THE CC PEPTIDYL-GLUTAMYL-PEPTIDE-HYDROLYZING ACTIVITY. CC -!- FUNCTION: THIS SUBUNIT IS NECESSARY FOR THE PEPTIDYLGLUTAMYL- CC PEPTIDE HYDROLYZING ACTIVITY. CC -!- PATHWAY: IS INVOLVED IN AN ATP/UBIQUITIN-DEPENDENT NON-LYSOSOMAL CC PROTEOLYTIC PATHWAY. CC -!- SUBUNIT: YEAST PROTEASOME SEEMS TO BE COMPOSED OF 14 DIFFERENT CC SUBUNITS WHICH FORM A HIGHLY ORDERED RING-SHAPED STRUCTURE. CC -!- SUBCELLULAR LOCATION: CYTOPLASMIC AND NUCLEAR. CC -!- SIMILARITY: BELONGS TO PEPTIDASE FAMILY S25B; ALSO KNOWN AS THE CC PROTEASOME B-TYPE FAMILY. BELONGS TO THE DELTA CHAIN SUBFAMILY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X78991; X78991. DR EMBL; Z49276; Z49276. DR EMBL; X87611; X87611. DR PIR; S43669; S43669. DR LISTA; SC01486; PRE3. DR SGD; L0001485; PRE3. DR PROSITE; PS00854; PROTEASOME_B. KW PROTEASOME; HYDROLASE; PROTEASE; ZYMOGEN. FT PROPEP 1 19 BY SIMILARITY. FT CHAIN 20 215 PROTEASOME COMPONENT PRE3. SQ SEQUENCE 215 AA; 23547 MW; 248400 CN; MNGIQVDINR LKKGEVSLGT SIMAVTFKDG VILGADSRTT TGAYIANRVT DKLTRVHDKI WCCRSGSAAD TQAIADIVQY HLELYTSQYG TPSTETAASV FKELCYENKD NLTAGIIVAG YDDKNKGEVY TIPLGGSVHK LPYAIAGSGS TFIYGYCDKN FRENMSKEET VDFIKHSLSQ AIKWDGSSGG VIRMVVLTAA GVERLIFYPD EYEQL //