ID PRCD_YEAST STANDARD; PRT; 193 AA. AC P38624; DT 01-OCT-1994 (REL. 30, CREATED) DT 01-OCT-1994 (REL. 30, LAST SEQUENCE UPDATE) DT 01-FEB-1995 (REL. 31, LAST ANNOTATION UPDATE) DE PROTEASOME COMPONENT PRE3 (EC 3.4.99.46) (MACROPAIN SUBUNIT PRE3) DE (PROTEINASE YSCE SUBUNIT PRE3) (MULTICATALYTIC ENDOPEPTIDASE COMPLEX DE SUBUNIT PRE3). GN PRE3. OS SACCHAROMYCES CEREVISIAE (BAKER'S YEAST). OC EUKARYOTA; FUNGI; ASCOMYCOTINA; HEMIASCOMYCETES. RN [1] RP SEQUENCE FROM N.A. RC STRAIN=S288C; RM 94185793 RA ENENKEL C., LEHMANN H., KIPPER J., GUECKEL R., HILT W., WOLF D.H.; RL FEBS LETT. 341:193-196(1994). CC -!- FUNCTION: THE PROTEASOME IS A MULTICATALYTIC PROTEINASE COMPLEX CC WHICH IS CHARACTERIZED BY ITS ABILITY TO CLEAVE PEPTIDES WITH CC ARG, PHE, TYR, LEU, AND GLU ADJACENT TO THE LEAVING GROUP AT CC NEUTRAL OR SLIGHTLY BASIC PH. THE PROTEASOME HAS AN ATP-DEPENDENT CC PROTEOLYTIC ACTIVITY. CC -!- FUNCTION: THIS SUBUNIT IS NECESSARY FOR THE PEPTIDYLGLUTAMYL- CC PEPTIDE HYDROLYZING ACTIVITY. CC -!- PATHWAY: IS INVOLVED IN AN ATP/UBIQUITIN-DEPENDENT NON-LYSOSOMAL CC PROTEOLYTIC PATHWAY. CC -!- SUBUNIT: YEAST PROTEASOME SEEMS TO BE COMPOSED OF 14 DIFFERENT CC SUBUNITS WHICH FORM A HIGHLY ORDERED RING-SHAPED STRUCTURE. CC -!- SUBCELLULAR LOCATION: CYTOPLASMIC AND NUCLEAR. CC -!- SIMILARITY: TO OTHER PROTEASOME B-TYPE SUBUNITS. BELONGS TO THE CC DELTA CHAIN SUBFAMILY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X78991; SCPRE3. DR PIR; S43669; S43669. KW PROTEASOME; HYDROLASE; PROTEASE. SQ SEQUENCE 193 AA; 21193 MW; 200678 CN; MAVTFKDGVI LGADSRTTTG AYIANRVTDK LTRVHDKIWC CRSGSAADTQ AIADIVQYHL ELYTSQYGTP STETAASVFK ELCYENKDNL TAGIIVAGYD DKNKGEVYTI PLGGSVHKLP YAIAGSGSTF IYGYCDKNFR ENMSKEETVD FIKHSLSQAI KWDGSSGGVI RMVVLTAAGV ERLIFYPDEY EQL //