ID MSG5_YEAST STANDARD; PRT; 489 AA. AC P38590; DT 01-OCT-1994 (REL. 30, CREATED) DT 01-OCT-1994 (REL. 30, LAST SEQUENCE UPDATE) DT 01-OCT-1994 (REL. 30, LAST ANNOTATION UPDATE) DE PROTEIN-TYROSINE PHOSPHATASE MSG5 (EC 3.1.3.48). GN MSG5. OS SACCHAROMYCES CEREVISIAE (BAKER'S YEAST). OC EUKARYOTA; FUNGI; ASCOMYCOTINA; HEMIASCOMYCETES. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 94139675. RA DOI K., GARTNER A., AMMERER G., ERREDE B., SHINKAWA H., RA SUGIMOTO K., MATSUMOTO K.; RL EMBO J. 13:61-70(1994). CC -!- FUNCTION: DUAL SPECIFICITY PHOSPHATASE THAT DEPHOSPHORYLATES MAP CC KINASE FUS3 ON BOTH A TYR AND A SER OR THR. HAS A ROLE IN CC ADAPTAION TO PHEROMONE. CC -!- CATALYTIC ACTIVITY: PROTEIN TYROSINE PHOSPHATE + H(2)O = CC PROTEIN TYROSINE + ORTHOPHOSPHATE. CC -!- SIMILARITY: BELONGS TO THE NON-RECEPTOR CLASS OF THE PROTEIN- CC TYROSINE PHOSPHATASE FAMILY. VH1 SUBFAMILY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; D17548; G459243; -. DR PIR; S40029; S40029. DR LISTA; SC00670; MSG5. DR SGD; L0001188; MSG5. DR PROSITE; PS00383; TYR_PHOSPHATASE. KW HYDROLASE; CELL CYCLE. FT ACT_SITE 319 319 FT MUTAGEN 319 319 C->A: LOSS OF ACTIVITY. SQ SEQUENCE 489 AA; 54219 MW; 281891E5 CRC32; MQFHSDKQHL DSKTDIDFKP NSPRSLQNRN TKNLSLDIAA LHPLMEFSSP SQDVPGSVKF PSPTPLNLFM KPKPIVLEKC PPKVSPRPTP PSLSMRRSEA SIYTLPTSLK NRTVSPSVYT KSSTVSSISK LSSSSPLSSF SEKPHLNRVH SLSVKTKDLK LKGIRGRSQT ISGLETSTPI SSTREGTLDS TDVNRFSNQK NMQTTLIFPE EDSDLNIDMV HAEIYQRTVY LDGPLLVLPP NLYLYSEPKL EDILSFDLVI NVAKEIPNLE FLIPPEMAHK IKYYHIEWTH TSKIVKDLSR LTRIIHTAHS QGKKILVHCQ CGVSRSASLI VAYIMRYYGL SLNDAYDELK GVAKDISPNM GLIFQLMEWG TMLSKNSPGE EGETVHMPEE DDIGNNEVSS TTKSYSSASF RSFPMVTNLS SSPNDSSVNS SEVTPRTPAT LTGARTALAT ERGEDDEHCK SLSQPADSLE ASVDNESIST APEQMMFLP //