ID AVR2_RAT STANDARD; PRT; 513 AA. AC P38444; DT 01-OCT-1994 (Rel. 30, Created) DT 01-OCT-1994 (Rel. 30, Last sequence update) DT 05-JUL-2004 (Rel. 44, Last annotation update) DE Activin receptor type II precursor (EC 2.7.1.37) (ACTR-II). GN Name=Acvr2; Synonyms=Actrii; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=Sprague-Dawley; TISSUE=Testis; RX MEDLINE=93279247; PubMed=7916681; RA Feng Z.M., Madigan M.B., Chen C.L.C.; RT "Expression of type II activin receptor genes in the male and female RT reproductive tissues of the rat."; RL Endocrinology 132:2593-2600(1993). RN [2] RP SEQUENCE FROM N.A. RC TISSUE=Ovary; RX MEDLINE=93050162; PubMed=1385212; RA Shinozaki H., Ito I., Hasegawa Y., Nakamura K., Igarashi S., RA Nakamura M., Miyamoto K., Eto Y., Ibuki Y., Minegishi T.; RT "Cloning and sequencing of a rat type II activin receptor."; RL FEBS Lett. 312:53-56(1992). CC -!- FUNCTION: Receptor for activin A, activin B and inhibin A. CC Involved in transmembrane signaling. CC -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. CC -!- SUBUNIT: Interacts with AIP1. Part of a complex consisting of CC AIP1, ACVR2, ACVR1B and MADH3 (By similarity). CC -!- SUBCELLULAR LOCATION: Type I membrane protein. CC -!- SIMILARITY: Belongs to the Ser/Thr protein kinase family. TGFB CC receptor subfamily. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L10639; AAA40674.1; -. DR EMBL; S48190; AAB23958.1; -. DR PIR; S27258; S27258. DR HSSP; P27038; 1BTE. DR RGD; 70911; Acvr2. DR InterPro; IPR000472; Activin_receptor. DR InterPro; IPR000333; Actn_receptorII. DR InterPro; IPR011009; Kinase_like. DR InterPro; IPR000719; Prot_kinase. DR InterPro; IPR008271; Ser_thr_pkin_AS. DR Pfam; PF01064; Activin_recp; 1. DR Pfam; PF00069; Pkinase; 1. DR PRINTS; PR00653; ACTIVIN2R. DR ProDom; PD000001; Prot_kinase; 1. DR PROSITE; PS00107; PROTEIN_KINASE_ATP; FALSE_NEG. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1. KW Receptor; Transferase; Serine/threonine-protein kinase; ATP-binding; KW Transmembrane; Glycoprotein; Signal. FT SIGNAL 1 19 Potential. FT CHAIN 20 513 Activin receptor type II. FT DOMAIN 20 135 Extracellular (Potential). FT TRANSMEM 136 161 Potential. FT DOMAIN 162 513 Cytoplasmic (Potential). FT DOMAIN 192 485 Protein kinase. FT NP_BIND 198 206 ATP (By similarity). FT BINDING 219 219 ATP (By similarity). FT ACT_SITE 322 322 Proton acceptor (By similarity). FT DISULFID 30 60 By similarity. FT DISULFID 50 78 By similarity. FT DISULFID 85 104 By similarity. FT DISULFID 91 103 By similarity. FT DISULFID 105 110 By similarity. FT CARBOHYD 43 43 N-linked (GlcNAc...) (Potential). FT CARBOHYD 66 66 N-linked (GlcNAc...) (Potential). FT CONFLICT 165 165 M -> K (in Ref. 2). FT CONFLICT 218 218 V -> I (in Ref. 2). FT CONFLICT 353 353 G -> A (in Ref. 2). FT CONFLICT 475 475 L -> V (in Ref. 2). SQ SEQUENCE 513 AA; 57892 MW; CE3A8742EF91DD7D CRC64; MGAAAKLAFA VFLISCSSGA ILGRSETQEC LFFNANWERD RTNQTGVEPC YGDKDKRRHC FATWKNISGS IEIVKQGCWL DDINCYDRTD CIEKKDSPEV YFCCCEGNMC NEKFSYFPEM EVTQPTSNPV TPKPPYYNIL LYSLVPLMLI AGIVICAFWV YRHHMMAYPP VLVPTQDPGP PPPSPLLGLK PLQLLEVKAR GRFGCVWKAQ LLNEYVAVKI FPIQDKQSWQ NEYEVYSLPG MKHENILQFI GAEKRGTSVD VDLWLITAFH EKGSLSDFLK ANVVSWNELC HIAETMARGL AYLHEDIPGL KDGHKPAISH RDIKSKNVLL KNNLTACIAD FGLALKFEAG KSGGDTHGQV GTRRYMAPEV LEGAINFQRD AFLRIDMYAM GLVLWELASR CTAADGPVDE YMLPFEEEIG QHPSLEDMQE VVVHKKKRPV LRDYWQKHAG MAMLCETIEE CWDHDAEARL SAGCLGERIT QMQRLTNIIT TEDIVTVVTM VTNVDFPPKE SSL //