ID SL11_YEAST STANDARD; PRT; 364 AA. AC P38241; P89497; DT 01-OCT-1994 (Rel. 30, Created) DT 01-OCT-1994 (Rel. 30, Last sequence update) DT 25-OCT-2004 (Rel. 45, Last annotation update) DE Splicing factor SLT11 (ECM2 protein). GN Name=ECM2; Synonyms=SLT11; OrderedLocusNames=YBR065C; GN ORFNames=YBR0614; OS Saccharomyces cerevisiae (Baker's yeast). OC Eukaryota; Fungi; Ascomycota; Saccharomycotina; Saccharomycetes; OC Saccharomycetales; Saccharomycetaceae; Saccharomyces. OX NCBI_TaxID=4932; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=S288c; RX MEDLINE=95112788; PubMed=7813418; RA Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., RA Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., RA Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., RA Cziepluch C., Demolis N., Delaveau T., Doignon F., Domdey H., RA Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., RA Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber H., RA Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., RA Herbert C.J., Hollenberg C.P., Holmstrom K., Jacq C., Jacquet M., RA Jauniaux J.-C., Jonniaux J.-L., Kallesoe T., Kiesau P., Kirchrath L., RA Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., RA Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., RA Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., RA Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., RA Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., RA Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., RA Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., RA Van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., RA Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., RA Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.; RT "Complete DNA sequence of yeast chromosome II."; RL EMBO J. 13:5795-5809(1994). RN [2] RP FUNCTION. RX PubMed=11158289; DOI=10.1128/MCB.21.4.1011-1023.2001; RA Xu D., Friesen J.D.; RT "Splicing factor slt11p and its involvement in formation of U2/U6 RT helix II in activation of the yeast spliceosome."; RL Mol. Cell. Biol. 21:1011-1023(2001). RN [3] RP SUBCELLULAR LOCATION. RX MEDLINE=22923954; PubMed=14562095; DOI=10.1038/nature02026; RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., RA Weissman J.S., O'Shea E.K.; RT "Global analysis of protein localization in budding yeast."; RL Nature 425:686-691(2003). CC -!- FUNCTION: Pre-mRNA splicing factor, facilitates the cooperative CC formation of U2/U6 helix II in association with stem II in the CC spliceosome. Binds to RNA. CC -!- SUBCELLULAR LOCATION: Nuclear. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; Z35934; CAA85008.1; -. DR EMBL; Z35935; CAA85009.1; -. DR PIR; S45925; S45925. DR IntAct; P38241; -. DR GermOnline; 138608; -. DR SGD; S000000269; ECM2. DR GO; GO:0005634; C:nucleus; IDA. DR GO; GO:0007047; P:cell wall organization and biogenesis; IMP. DR GO; GO:0000398; P:nuclear mRNA splicing, via spliceosome; IGI. KW mRNA splicing; Nuclear protein; RNA-binding. SQ SEQUENCE 364 AA; 40925 MW; BF21E687817A42B4 CRC64; MNDEINEPPP NICEQCLGDE ANIRMTKIPQ GSECKICTLP FTLYHFKTSK RSNNIIKTLI CVRCATQRNI CQCCMLDSRW HIPIQLRDHL ISLVNEENVM TEEAKNDMMK RFLSLKNVKL GGAQITSDPS EADNIVDKLK NILLRATSDG PSTPLIKNTT ALYKNEKGAN EVKNLEKYAS VDISHILKKL PLNESFLKNP STKSFFLYNI DASIPEWKIT DTVSQLLGIK KWKDGNSLSL IVNHKAKCGG LRFQSSELGE RFVSKISETL VTPKGLKRGV LLIDRFRIFI IPWSSGFSAA SFGTNTAENI KLSLSLNKLI QLELGLSFPT KSTDNAKNDK KKTSKKVHKD RSKKSKPRAN KLTI //