ID SYU_TETCF Reviewed; 143 AA. AC P37379; DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1995, sequence version 2. DT 11-DEC-2019, entry version 71. DE RecName: Full=Synuclein; OS Tetronarce californica (Pacific electric ray) (Torpedo californica). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes; OC Elasmobranchii; Batoidea; Torpediniformes; Torpedinidae; Tetronarce. OX NCBI_TaxID=7787; RN [1] RP NUCLEOTIDE SEQUENCE. RX PubMed=3411354; DOI=10.1523/jneurosci.08-08-02804.1988; RA Maroteaux L., Campanelli J.T., Scheller R.H.; RT "Synuclein: a neuron-specific protein localized to the nucleus and RT presynaptic nerve terminal."; RL J. Neurosci. 8:2804-2815(1988). CC -!- FUNCTION: May have a role in synaptic regulation or signal CC transduction. CC -!- SUBCELLULAR LOCATION: Nucleus. CC -!- TISSUE SPECIFICITY: Nervous system tissue. Found in the electric lobe, CC the brain and the spinal cord. CC -!- MISCELLANEOUS: Three isoforms are detected: 17.5 kDa, 18.5 kDa and 20.0 CC kDa. In the neuronal cell soma, the 17.5 kDa species is predominant. CC -!- SIMILARITY: Belongs to the synuclein family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR PIR; A60887; A60887. DR SMR; P37379; -. DR PRIDE; P37379; -. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR InterPro; IPR001058; Synuclein. DR InterPro; IPR002462; Synuclein_gamma. DR PANTHER; PTHR13820; PTHR13820; 2. DR Pfam; PF01387; Synuclein; 2. DR PRINTS; PR01214; GSYNUCLEIN. DR PRINTS; PR01211; SYNUCLEIN. PE 2: Evidence at transcript level; KW Nucleus; Repeat. FT CHAIN 1..143 FT /note="Synuclein" FT /id="PRO_0000184041" FT REPEAT 20..30 FT /note="1" FT REPEAT 31..41 FT /note="2" FT REPEAT 42..52 FT /note="3" FT REPEAT 53..67 FT /note="4; approximate" FT REPEAT 68..78 FT /note="5" FT REGION 20..78 FT /note="5 X 11 AA tandem repeats of [EGST]-K-T-K-[EQ]-[GQ]- FT [VA]-X(4)" SQ SEQUENCE 143 AA; 14831 MW; 51872507471C2BC2 CRC64; MDVLKKGFSF AKEGVVAAAE KTKQGVQDAA EKTKQGVQDA AEKTKEGVMY VGTKTKEGVV QSVNTVTEKT KEQANVVGGA VVAGVNTVAS KTVEGVENVA AASGVVKLDE HGREIPAEQV AEGKQTTQEP LVEATEATEE TGK //