ID SYU_TORCA Reviewed; 143 AA. AC P37379; DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1995, sequence version 2. DT 28-NOV-2006, entry version 34. DE Synuclein. OS Torpedo californica (Pacific electric ray). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes; OC Elasmobranchii; Squalea; Hypnosqualea; Pristiorajea; Batoidea; OC Torpediniformes; Torpedinoidei; Torpedinidae; Torpedo. OX NCBI_TaxID=7787; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=88316381; PubMed=3411354; RA Maroteaux L., Campanelli J.T., Scheller R.H.; RT "Synuclein: a neuron-specific protein localized to the nucleus and RT presynaptic nerve terminal."; RL J. Neurosci. 8:2804-2815(1988). CC -!- FUNCTION: May have a role in synaptic regulation or signal CC transduction. CC -!- SUBCELLULAR LOCATION: Nucleus. CC -!- TISSUE SPECIFICITY: Nervous system tissue. Found in the electric CC lobe, the brain and the spinal cord. CC -!- MISCELLANEOUS: Three isoforms are detected: 17.5 kDa, 18.5 kDa and CC 20.0 kDa. In the neuronal cell soma, the 17.5 kDa species is CC predominant. CC -!- SIMILARITY: Belongs to the synuclein family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR PIR; A60887; A60887. DR InterPro; IPR013326; ApoA/E_ApoLp. DR InterPro; IPR001058; Synuclein. DR InterPro; IPR002462; Synuclein_gamma. DR Gene3D; G3DSA:1.20.120.20; ApoA1_A4_E; 1. DR Pfam; PF01387; Synuclein; 1. DR PRINTS; PR01214; GSYNUCLEIN. DR PRINTS; PR01211; SYNUCLEIN. DR ProDom; PD010631; Synuclein; 1. KW Nuclear protein; Repeat. FT CHAIN 1 143 Synuclein. FT /FTId=PRO_0000184041. FT REPEAT 20 30 1. FT REPEAT 31 41 2. FT REPEAT 42 52 3. FT REPEAT 53 67 4; approximate. FT REPEAT 68 78 5. FT REGION 20 78 5 X 11 AA tandem repeats of [EGST]-K-T-K- FT [EQ]-[GQ]-[VA]-X(4). SQ SEQUENCE 143 AA; 14831 MW; 51872507471C2BC2 CRC64; MDVLKKGFSF AKEGVVAAAE KTKQGVQDAA EKTKQGVQDA AEKTKEGVMY VGTKTKEGVV QSVNTVTEKT KEQANVVGGA VVAGVNTVAS KTVEGVENVA AASGVVKLDE HGREIPAEQV AEGKQTTQEP LVEATEATEE TGK //