ID SYU_TORCA STANDARD; PRT; 143 AA. AC P37379; DT 01-OCT-1994 (Rel. 30, Created) DT 01-FEB-1995 (Rel. 31, Last sequence update) DT 01-NOV-1997 (Rel. 35, Last annotation update) DE SYNUCLEIN. OS Torpedo californica (Pacific electric ray). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes; OC Elasmobranchii; Squalea; Hypnosqualea; Pristiorajea; Batoidea; OC Torpediniformes; Torpedinoidei; Torpedinidae; Torpedo. OX NCBI_TaxID=7787; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=88316381; PubMed=3411354; RA Maroteaux L., Campanelli J.T., Scheller R.H.; RT "Synuclein: a neuron-specific protein localized to the nucleus and RT presynaptic nerve terminal."; RL J. Neurosci. 8:2804-2815(1988). CC -!- FUNCTION: MAY HAVE A ROLE IN SYNAPTIC REGULATION OR SIGNAL CC TRANSDUCTION. CC -!- SUBCELLULAR LOCATION: NUCLEAR. CC -!- TISSUE SPECIFICITY: NERVOUS SYSTEM TISSUE. FOUND IN THE ELECTRIC CC LOBE, THE BRAIN AND THE SPINAL CORD. CC -!- MISCELLANEOUS: THREE ISOFORMS ARE DETECTED: 17.5 KDA, 18.5 KDA AND CC 20.0 KDA. IN THE NEURONAL CELL SOMA, THE 17.5 KDA SPECIES IS CC PREDOMINANT. CC -!- SIMILARITY: BELONGS TO THE SYNUCLEIN FAMILY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR PIR; A60887; A60887. DR InterPro; IPR001058; Synuclein. DR Pfam; PF01387; Synuclein; 1. DR PRINTS; PR01211; SYNUCLEIN. DR ProDom; PD010631; -; 1. KW Repeat; Nuclear protein. FT DOMAIN 20 78 5 X 11 AA TANDEM REPEATS OF [EGST]-K-T-K- FT [EQ]-[GQ]-[VA]-X(4). FT REPEAT 20 30 1. FT REPEAT 31 41 2. FT REPEAT 42 52 3. FT REPEAT 53 67 4 (APPROXIMATE). FT REPEAT 68 78 5. SQ SEQUENCE 143 AA; 14831 MW; 51872507471C2BC2 CRC64; MDVLKKGFSF AKEGVVAAAE KTKQGVQDAA EKTKQGVQDA AEKTKEGVMY VGTKTKEGVV QSVNTVTEKT KEQANVVGGA VVAGVNTVAS KTVEGVENVA AASGVVKLDE HGREIPAEQV AEGKQTTQEP LVEATEATEE TGK //