ID ZNF76_HUMAN Reviewed; 570 AA. AC P36508; Q9BQB2; DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot. DT 02-MAY-2002, sequence version 2. DT 09-APR-2025, entry version 212. DE RecName: Full=Zinc finger protein 76; DE AltName: Full=Zinc finger protein 523; GN Name=ZNF76; Synonyms=D6S229E, ZNF523; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). RX PubMed=1427894; DOI=10.1016/s0888-7543(05)80167-3; RA Ragoussis J., Senger G., Mockridge I., Sanseau P., Ruddy S., Dudley K., RA Sheer D., Trowsdale J.; RT "A testis-expressed Zn finger gene (ZNF76) in human 6p21.3 centromeric to RT the MHC is closely linked to the human homolog of the T-complex gene tcp- RT 11."; RL Genomics 14:673-679(1992). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., RA Phelan M., Farmer A.; RT "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."; RL Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RC TISSUE=Placenta; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [4] RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-24, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=28112733; DOI=10.1038/nsmb.3366; RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C., RA Nielsen M.L.; RT "Site-specific mapping of the human SUMO proteome reveals co-modification RT with phosphorylation."; RL Nat. Struct. Mol. Biol. 24:325-336(2017). CC -!- FUNCTION: May be involved in transcriptional regulation. CC -!- INTERACTION: CC P36508; Q9BWD1: ACAT2; NbExp=3; IntAct=EBI-7254550, EBI-1047273; CC P36508; Q9BYJ1: ALOXE3; NbExp=3; IntAct=EBI-7254550, EBI-6925949; CC P36508; Q7Z713: ANKRD37; NbExp=3; IntAct=EBI-7254550, EBI-12373689; CC P36508; Q9BQD7: ANTKMT; NbExp=3; IntAct=EBI-7254550, EBI-713602; CC P36508; P48047: ATP5PO; NbExp=3; IntAct=EBI-7254550, EBI-355815; CC P36508; Q9H2G9: BLZF1; NbExp=3; IntAct=EBI-7254550, EBI-2548012; CC P36508; A0A087WZT3: BOLA2-SMG1P6; NbExp=3; IntAct=EBI-7254550, EBI-12006120; CC P36508; Q5SWW7: C10orf55; NbExp=3; IntAct=EBI-7254550, EBI-12809220; CC P36508; Q8WYQ4-2: C22orf15; NbExp=3; IntAct=EBI-7254550, EBI-12030460; CC P36508; Q3SXR2: C3orf36; NbExp=3; IntAct=EBI-7254550, EBI-18036948; CC P36508; P40199: CEACAM6; NbExp=3; IntAct=EBI-7254550, EBI-4314501; CC P36508; Q8TAP6: CEP76; NbExp=3; IntAct=EBI-7254550, EBI-742887; CC P36508; P07498: CSN3; NbExp=3; IntAct=EBI-7254550, EBI-2602175; CC P36508; Q96D03: DDIT4L; NbExp=3; IntAct=EBI-7254550, EBI-742054; CC P36508; Q9NRI5-2: DISC1; NbExp=3; IntAct=EBI-7254550, EBI-11988027; CC P36508; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-7254550, EBI-744099; CC P36508; Q9Y3B2: EXOSC1; NbExp=3; IntAct=EBI-7254550, EBI-371892; CC P36508; Q86W67: FAM228A; NbExp=3; IntAct=EBI-7254550, EBI-12958227; CC P36508; Q86YD7: FAM90A1; NbExp=3; IntAct=EBI-7254550, EBI-6658203; CC P36508; Q96PJ5: FCRL4; NbExp=3; IntAct=EBI-7254550, EBI-4314687; CC P36508; Q14192: FHL2; NbExp=4; IntAct=EBI-7254550, EBI-701903; CC P36508; Q8TC99: FNDC8; NbExp=3; IntAct=EBI-7254550, EBI-12903902; CC P36508; A1L4K1: FSD2; NbExp=3; IntAct=EBI-7254550, EBI-5661036; CC P36508; Q8TC17: GRAPL; NbExp=3; IntAct=EBI-7254550, EBI-18300553; CC P36508; Q9UKT9: IKZF3; NbExp=3; IntAct=EBI-7254550, EBI-747204; CC P36508; Q7L273: KCTD9; NbExp=3; IntAct=EBI-7254550, EBI-4397613; CC P36508; Q9UIH9: KLF15; NbExp=3; IntAct=EBI-7254550, EBI-2796400; CC P36508; O00505: KPNA3; NbExp=3; IntAct=EBI-7254550, EBI-358297; CC P36508; Q6A162: KRT40; NbExp=3; IntAct=EBI-7254550, EBI-10171697; CC P36508; O95678: KRT75; NbExp=3; IntAct=EBI-7254550, EBI-2949715; CC P36508; Q96JM7-2: L3MBTL3; NbExp=3; IntAct=EBI-7254550, EBI-11985629; CC P36508; P28838: LAP3; NbExp=3; IntAct=EBI-7254550, EBI-2339312; CC P36508; O95202: LETM1; NbExp=3; IntAct=EBI-7254550, EBI-1052895; CC P36508; Q9UBR4-2: LHX3; NbExp=5; IntAct=EBI-7254550, EBI-12039345; CC P36508; Q969G2: LHX4; NbExp=3; IntAct=EBI-7254550, EBI-2865388; CC P36508; Q9UPM6: LHX6; NbExp=3; IntAct=EBI-7254550, EBI-10258746; CC P36508; Q96GY3: LIN37; NbExp=3; IntAct=EBI-7254550, EBI-748884; CC P36508; Q6MZP7: LIN54; NbExp=3; IntAct=EBI-7254550, EBI-1389411; CC P36508; P25800: LMO1; NbExp=3; IntAct=EBI-7254550, EBI-8639312; CC P36508; P43360: MAGEA6; NbExp=3; IntAct=EBI-7254550, EBI-1045155; CC P36508; Q8WWY6: MBD3L1; NbExp=3; IntAct=EBI-7254550, EBI-12516603; CC P36508; Q9P267-2: MBD5; NbExp=3; IntAct=EBI-7254550, EBI-17671489; CC P36508; A0JLT2-2: MED19; NbExp=3; IntAct=EBI-7254550, EBI-13288755; CC P36508; P55081: MFAP1; NbExp=3; IntAct=EBI-7254550, EBI-1048159; CC P36508; Q6PF18: MORN3; NbExp=3; IntAct=EBI-7254550, EBI-9675802; CC P36508; P52815: MRPL12; NbExp=3; IntAct=EBI-7254550, EBI-358272; CC P36508; Q9H019: MTFR1L; NbExp=3; IntAct=EBI-7254550, EBI-2824497; CC P36508; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-7254550, EBI-11522433; CC P36508; Q9BUA6: MYL10; NbExp=3; IntAct=EBI-7254550, EBI-17561739; CC P36508; Q14511-2: NEDD9; NbExp=3; IntAct=EBI-7254550, EBI-11746523; CC P36508; Q9BQI9: NRIP2; NbExp=3; IntAct=EBI-7254550, EBI-3913975; CC P36508; Q10713: PMPCA; NbExp=3; IntAct=EBI-7254550, EBI-2514696; CC P36508; Q7Z3K3: POGZ; NbExp=3; IntAct=EBI-7254550, EBI-1389308; CC P36508; P31321: PRKAR1B; NbExp=3; IntAct=EBI-7254550, EBI-2805516; CC P36508; Q96QF0-7: RAB3IP; NbExp=3; IntAct=EBI-7254550, EBI-11984839; CC P36508; Q53GL6: RALY; NbExp=3; IntAct=EBI-7254550, EBI-9512693; CC P36508; Q04864-2: REL; NbExp=3; IntAct=EBI-7254550, EBI-10829018; CC P36508; Q96P16-3: RPRD1A; NbExp=3; IntAct=EBI-7254550, EBI-12840198; CC P36508; P63220: RPS21; NbExp=3; IntAct=EBI-7254550, EBI-714051; CC P36508; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-7254550, EBI-748391; CC P36508; Q8ND83: SLAIN1; NbExp=3; IntAct=EBI-7254550, EBI-10269374; CC P36508; O43623: SNAI2; NbExp=3; IntAct=EBI-7254550, EBI-9876238; CC P36508; Q5MJ09: SPANXN3; NbExp=3; IntAct=EBI-7254550, EBI-12037215; CC P36508; Q6RVD6: SPATA8; NbExp=3; IntAct=EBI-7254550, EBI-8635958; CC P36508; Q6ZNM6: SPMIP10; NbExp=3; IntAct=EBI-7254550, EBI-18115728; CC P36508; Q9NZ72: STMN3; NbExp=3; IntAct=EBI-7254550, EBI-725557; CC P36508; Q5VWN6: TASOR2; NbExp=3; IntAct=EBI-7254550, EBI-745958; CC P36508; Q9NU19: TBC1D22B; NbExp=3; IntAct=EBI-7254550, EBI-8787464; CC P36508; Q96M29: TEKT5; NbExp=3; IntAct=EBI-7254550, EBI-10239812; CC P36508; Q96RS0: TGS1; NbExp=3; IntAct=EBI-7254550, EBI-949244; CC P36508; P19237: TNNI1; NbExp=3; IntAct=EBI-7254550, EBI-746692; CC P36508; Q70EL1-9: USP54; NbExp=3; IntAct=EBI-7254550, EBI-11975223; CC P36508; Q93009: USP7; NbExp=3; IntAct=EBI-7254550, EBI-302474; CC P36508; Q8TAG6: VXN; NbExp=3; IntAct=EBI-7254550, EBI-12071548; CC P36508; Q9BRX9: WDR83; NbExp=3; IntAct=EBI-7254550, EBI-7705033; CC P36508; Q53FD0-2: ZC2HC1C; NbExp=3; IntAct=EBI-7254550, EBI-14104088; CC P36508; Q9NQZ6: ZC4H2; NbExp=5; IntAct=EBI-7254550, EBI-747993; CC P36508; O95789-4: ZMYM6; NbExp=3; IntAct=EBI-7254550, EBI-12949277; CC P36508; Q8TAQ5: ZNF420; NbExp=3; IntAct=EBI-7254550, EBI-3923307; CC P36508; Q8TF50: ZNF526; NbExp=3; IntAct=EBI-7254550, EBI-11035148; CC P36508; O75123: ZNF623; NbExp=3; IntAct=EBI-7254550, EBI-18560922; CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=2; CC IsoId=P36508-1; Sequence=Displayed; CC Name=1; CC IsoId=P36508-2; Sequence=VSP_006894; CC -!- TISSUE SPECIFICITY: Testis. CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein CC family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M91592; AAA98739.1; -; mRNA. DR EMBL; BT007316; AAP35980.1; -; mRNA. DR EMBL; BC000133; AAH00133.1; -; mRNA. DR EMBL; BC002549; AAH02549.1; -; mRNA. DR CCDS; CCDS4801.1; -. [P36508-1] DR CCDS; CCDS75435.1; -. [P36508-2] DR PIR; A44256; A44256. DR RefSeq; NP_001278961.1; NM_001292032.2. [P36508-2] DR RefSeq; NP_003418.2; NM_003427.4. [P36508-1] DR RefSeq; XP_016866738.1; XM_017011249.3. [P36508-1] DR RefSeq; XP_016866745.1; XM_017011256.2. [P36508-2] DR RefSeq; XP_054212293.1; XM_054356318.1. [P36508-1] DR RefSeq; XP_054212301.1; XM_054356326.1. [P36508-2] DR AlphaFoldDB; P36508; -. DR SMR; P36508; -. DR BioGRID; 113448; 104. DR IntAct; P36508; 87. DR MINT; P36508; -. DR STRING; 9606.ENSP00000363064; -. DR iPTMnet; P36508; -. DR PhosphoSitePlus; P36508; -. DR BioMuta; ZNF76; -. DR DMDM; 20455531; -. DR jPOST; P36508; -. DR MassIVE; P36508; -. DR PaxDb; 9606-ENSP00000363064; -. DR PeptideAtlas; P36508; -. DR ProteomicsDB; 55204; -. [P36508-1] DR ProteomicsDB; 55205; -. [P36508-2] DR Antibodypedia; 15181; 168 antibodies from 26 providers. DR DNASU; 7629; -. DR Ensembl; ENST00000339411.5; ENSP00000344097.5; ENSG00000065029.15. [P36508-2] DR Ensembl; ENST00000373953.8; ENSP00000363064.3; ENSG00000065029.15. [P36508-1] DR GeneID; 7629; -. DR KEGG; hsa:7629; -. DR MANE-Select; ENST00000373953.8; ENSP00000363064.3; NM_003427.5; NP_003418.2. DR UCSC; uc003oki.2; human. [P36508-1] DR AGR; HGNC:13149; -. DR CTD; 7629; -. DR DisGeNET; 7629; -. DR GeneCards; ZNF76; -. DR HGNC; HGNC:13149; ZNF76. DR HPA; ENSG00000065029; Low tissue specificity. DR MIM; 194549; gene. DR neXtProt; NX_P36508; -. DR OpenTargets; ENSG00000065029; -. DR PharmGKB; PA37723; -. DR VEuPathDB; HostDB:ENSG00000065029; -. DR eggNOG; KOG1721; Eukaryota. DR GeneTree; ENSGT00940000160911; -. DR HOGENOM; CLU_027168_0_0_1; -. DR InParanoid; P36508; -. DR OMA; HCKPYSC; -. DR OrthoDB; 6077919at2759; -. DR PhylomeDB; P36508; -. DR TreeFam; TF333498; -. DR PathwayCommons; P36508; -. DR SignaLink; P36508; -. DR SIGNOR; P36508; -. DR BioGRID-ORCS; 7629; 20 hits in 1176 CRISPR screens. DR ChiTaRS; ZNF76; human. DR GeneWiki; ZNF76; -. DR GenomeRNAi; 7629; -. DR Pharos; P36508; Tbio. DR PRO; PR:P36508; -. DR Proteomes; UP000005640; Chromosome 6. DR RNAct; P36508; protein. DR Bgee; ENSG00000065029; Expressed in right lobe of thyroid gland and 175 other cell types or tissues. DR ExpressionAtlas; P36508; baseline and differential. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central. DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central. DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:NTNU_SB. DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL. DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB. DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central. DR GO; GO:0006359; P:regulation of transcription by RNA polymerase III; TAS:ProtInc. DR FunFam; 3.30.160.60:FF:004334; -; 1. DR FunFam; 3.30.160.60:FF:000071; Putative zinc finger protein 143; 1. DR FunFam; 3.30.160.60:FF:000125; Putative zinc finger protein 143; 1. DR FunFam; 3.30.160.60:FF:000137; Putative zinc finger protein 143; 1. DR FunFam; 3.30.160.60:FF:000142; Putative zinc finger protein 143; 1. DR FunFam; 3.30.160.60:FF:000072; zinc finger protein 143 isoform X1; 1. DR FunFam; 3.30.160.60:FF:000236; zinc finger protein 143 isoform X1; 1. DR Gene3D; 3.30.160.60; Classic Zinc Finger; 7. DR InterPro; IPR036236; Znf_C2H2_sf. DR InterPro; IPR013087; Znf_C2H2_type. DR PANTHER; PTHR14003; TRANSCRIPTIONAL REPRESSOR PROTEIN YY; 1. DR PANTHER; PTHR14003:SF23; ZINC FINGER PROTEIN 143; 1. DR Pfam; PF00096; zf-C2H2; 5. DR SMART; SM00355; ZnF_C2H2; 7. DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 4. DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7. DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 7. PE 1: Evidence at protein level; KW Alternative splicing; DNA-binding; Isopeptide bond; Metal-binding; Nucleus; KW Proteomics identification; Reference proteome; Repeat; Transcription; KW Transcription regulation; Ubl conjugation; Zinc; Zinc-finger. FT CHAIN 1..570 FT /note="Zinc finger protein 76" FT /id="PRO_0000047386" FT REPEAT 34..45 FT /note="1" FT REPEAT 62..73 FT /note="2" FT REPEAT 88..99 FT /note="3" FT ZN_FING 165..189 FT /note="C2H2-type 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 195..219 FT /note="C2H2-type 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 225..249 FT /note="C2H2-type 3" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 255..279 FT /note="C2H2-type 4" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 285..309 FT /note="C2H2-type 5" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 315..339 FT /note="C2H2-type 6" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 345..368 FT /note="C2H2-type 7" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT REGION 34..99 FT /note="3 X 12 AA approximate repeats" FT REGION 365..401 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 379..395 FT /note="Low complexity" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT CROSSLNK 24 FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with FT G-Cter in SUMO2)" FT /evidence="ECO:0007744|PubMed:28112733" FT VAR_SEQ 444..498 FT /note="Missing (in isoform 1)" FT /evidence="ECO:0000303|PubMed:1427894" FT /id="VSP_006894" FT VARIANT 48 FT /note="T -> M (in dbSNP:rs2228265)" FT /id="VAR_033546" FT VARIANT 272 FT /note="R -> C (in dbSNP:rs33959228)" FT /id="VAR_033547" FT VARIANT 403 FT /note="R -> Q (in dbSNP:rs35582935)" FT /id="VAR_033548" FT CONFLICT 334..335 FT /note="KH -> ND (in Ref. 1; AAA98739)" FT /evidence="ECO:0000305" SQ SEQUENCE 570 AA; 61831 MW; 333C99E0E79D86C2 CRC64; MESLGLHTVT LSDGTTAYVQ QAVKGEKLLE GQVIQLEDGT TAYIHQVTVQ KEALSFEDGQ PVQLEDGSMA YIHRTPREGY DPSTLEAVQL EDGSTAYIHH PVAVPSESTI LAVQTEVGLE DLAAEDDEGF SADAVVALEQ YASKVLHDSQ IPRNGKGQQV GDRAFRCGYK GCGRLYTTAH HLKVHERAHT GDRPYRCDFP SCGKAFATGY GLKSHVRTHT GEKPYKCPEE LCSKAFKTSG DLQKHVRTHT GERPFQCPFE GCGRSFTTSN IRKVHVRTHT GERPYTCPEP HCGRGFTSAT NYKNHVRIHT GEKPYVCTVP GCGKRFTEYS SLYKHHVVHT HCKPYTCSTC GKTYRQTSTL AMHKRSAHGE LEATEESEQA LYEQQQLEAA SAAEESPPPK RPRIAYLSEV KEERDDIPAQ VAMVTEEDGA PQVALITQDG AQQVSLSPED LQALGSAISM VTQHGSTTLT IPSPDADLAT SGTHTVTMVS ADGTQTQPVT IITSGAVVAE DSSVASLRHQ QVALLATANG THIAVQLEEQ QTLEEAINVA TAAMQQGAVT LETTVSESGC //