ID RET_MOUSE STANDARD; PRT; 1115 AA. AC P35546; DT 01-JUN-1994 (REL. 29, CREATED) DT 01-JUN-1994 (REL. 29, LAST SEQUENCE UPDATE) DT 01-NOV-1995 (REL. 32, LAST ANNOTATION UPDATE) DE PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET PRECURSOR DE (EC 2.7.1.112) (C-RET). GN RET. OS MUS MUSCULUS (MOUSE). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; MAMMALIA; EUTHERIA; OC RODENTIA; SCIUROGNATHI; MURIDAE; MURINAE; MUS. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 93205390. RA IWAMOTO T., TANIGUCHI M., ASAI N., OHKUSU K., NAKASHIMA I., RA TAKAHASHI M.; RT "cDNA cloning of mouse ret proto-oncogene and its sequence similarity RT to the cadherin superfamily."; RL ONCOGENE 8:1087-1091(1993). CC -!- FUNCTION: PROBABLE RECEPTOR WITH TYROSINE-PROTEIN KINASE ACTIVITY; CC IMPORTANT FOR DEVELOPMENT. CC -!- CATALYTIC ACTIVITY: ATP + A PROTEIN TYROSINE = ADP + CC PROTEIN TYROSINE PHOSPHATE. CC -!- SUBCELLULAR LOCATION: TYPE I MEMBRANE PROTEIN. CC -!- TISSUE SPECIFICITY: EXPRESSED IN PERIPHERAL NERVE CELLS AND CC HEMATOPOIETIC CELLS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X67812; G53974; -. DR PIR; S29926; S29926. DR MGD; MGI:97902; RET. DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1. DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PFAM; PF00028; cadherin; 1. DR PFAM; PF00069; pkinase; 1. DR HSSP; P11362; 1AGW. KW TRANSFERASE; TYROSINE-PROTEIN KINASE; ATP-BINDING; PROTO-ONCOGENE; KW TRANSMEMBRANE; GLYCOPROTEIN; SIGNAL. FT SIGNAL 1 28 POTENTIAL. FT CHAIN 29 1115 PROTO-ONCOGENE TYROSINE-PROTEIN KINASE FT RECEPTOR RET. FT DOMAIN 29 637 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 638 659 POTENTIAL. FT DOMAIN 660 1115 CYTOPLASMIC (POTENTIAL). FT DOMAIN 725 1017 PROTEIN KINASE. FT NP_BIND 731 739 ATP (BY SIMILARITY). FT BINDING 759 759 ATP (BY SIMILARITY). FT ACT_SITE 875 875 BY SIMILARITY. FT CARBOHYD 89 89 POTENTIAL. FT CARBOHYD 98 98 POTENTIAL. FT CARBOHYD 151 151 POTENTIAL. FT CARBOHYD 156 156 POTENTIAL. FT CARBOHYD 199 199 POTENTIAL. FT CARBOHYD 345 345 POTENTIAL. FT CARBOHYD 360 360 POTENTIAL. FT CARBOHYD 378 378 POTENTIAL. FT CARBOHYD 396 396 POTENTIAL. FT CARBOHYD 450 450 POTENTIAL. FT CARBOHYD 470 470 POTENTIAL. FT CARBOHYD 556 556 POTENTIAL. SQ SEQUENCE 1115 AA; 123728 MW; 089A938E CRC32; MAKATSGAAG LGLKLILLLP LLGEAPLGLY FSRDAYWERL YVDQPAGTPL LYVHALRDAP GEVPSFRLGQ HLYGVYRTRL HENDWIRINE TTGLLYLNQS LDHSSWEQLS IRNGGFPLLT IFLQVFLGST AQREGECHWP GCTRVYFSFI NDTFPNCSSF KAQDLCIPET AVSSRVRENX PPGTFYHFHM LPVQFLCPNI SVKYSLLGGD SLPFRCDPDC LEVSTRWALD RELREKYVLE ALCIVAGPGA NKETVTLSFP VTVYDEDDSA PTFSGGVGTA SAVVEFKRKE GTVVATLQVF DADVVPASGE LVRRYTNTLL SGDSWAQQTF RVEHSPIETL VQVNNNSVRA TMHNYKLILN RSLSISESRV LQLAVLVNDS DFQGPGAGGI LVLHFNVSVL PVTLNLPRAY SFPVNKRARR YAQIGKVCVE NCQEFSGVSI QYKLQPSSIN CTALGVVTSP EDTSGTLFVN DTEALRRPEC TKLQYTVVAT DRQTRRQTQA SLVVTVEGTS ITEEVGCPKS CAVNKRRPEC EECGGLGSPT GRCEWRQGDG KGITRNFSTC SPSTRTCPDG HCDAVESRDA NICPQDCLRA DIVGGHERGE RQGIKAGYGI CNCFPDEKKC FCEPEDSQGP LCDALCRTII TAALFSLIIS ILLSIFCVCH HHKHGHKPPI ASAEMTFCRP AQGFPISYSS SGTRRPSLDS TENQVPVDSF KIPEDPKWEF PRKNLVLGKT LGEGEFGKVV XATAFRLKGR AGYTTVAVKX LKENASQSEL RDLLSEFNLL KQVNHPHVIK LYGACSQDGP LLLIVEYAKY GSLRGFLRDS RKIGPAYVSG GGSRNSSSLD HPDERVLTMG DLISFAWQIS RGMQYLAEMK LVHRDLAARN ILVAEGRKMK ISDFGLSRDV YEEDSYVKKS KGRIPVKWMA IESLFDHIYT TQSDVWSFGV LLWEIVTLGG NPYPGIPPER LFNLLKTGHR MERPDNCSEE MYRLMLQCWK QEPDKRPVFA DISKDLEKMM VKSRDYLDLA ASTPSDSLLY DDGLSEEETP LVDCNNAPLP RSLPSTWIEN KLYGMSDPNW PGESPVPLTR ADGTSTGFPR YANDSVYANW MVSPSAAKLM DTFDS //