ID RET_MOUSE STANDARD; PRT; 1115 AA. AC P35546; DT 01-JUN-1994 (REL. 29, CREATED) DT 01-JUN-1994 (REL. 29, LAST SEQUENCE UPDATE) DT 01-FEB-1995 (REL. 31, LAST ANNOTATION UPDATE) DE PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET PRECURSOR DE (EC 2.7.1.112) (C-RET). GN RET. OS MUS MUSCULUS (MOUSE). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; RODENTIA. RN [1] RP SEQUENCE FROM N.A. RM 93205390 RA IWAMOTO T., TANIGUCHI M., ASAI N., OHKUSU K., NAKASHIMA I., RA TAKAHASHI M.; RL ONCOGENE 8:1087-1091(1993). CC -!- FUNCTION: PROBABLE RECEPTOR WITH TYROSINE-PROTEIN KINASE ACTIVITY; CC IMPORTANT FOR DEVELOPMENT. CC -!- CATALYTIC ACTIVITY: ATP + A PROTEIN TYROSINE = ADP + CC PROTEIN TYROSINE PHOSPHATE. CC -!- SUBCELLULAR LOCATION: TYPE I MEMBRANE PROTEIN. CC -!- TISSUE SPECIFICITY: EXPRESSED IN PERIPHERAL NERVE CELLS AND CC HEMATOPOIETIC CELLS. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X67812; MMRET. DR PIR; S29926; S29926. DR PROSITE; PS00107; PROTEIN_KINASE_ATP. DR PROSITE; PS00109; PROTEIN_KINASE_TYR. KW TRANSFERASE; TYROSINE-PROTEIN KINASE; ATP-BINDING; PROTO-ONCOGENE; KW TRANSMEMBRANE; GLYCOPROTEIN; SIGNAL. FT SIGNAL 1 28 POTENTIAL. FT CHAIN 29 1115 PROTO-ONCOGENE TYROSINE-PROTEIN KINASE FT RECEPTOR RET. FT DOMAIN 29 637 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 638 659 POTENTIAL. FT DOMAIN 660 1115 CYTOPLASMIC (POTENTIAL). FT DOMAIN 723 1000 CATALYTIC. FT NP_BIND 731 739 ATP (BY SIMILARITY). FT BINDING 759 759 ATP (BY SIMILARITY). FT ACT_SITE 875 875 BY SIMILARITY. FT CARBOHYD 89 89 POTENTIAL. FT CARBOHYD 98 98 POTENTIAL. FT CARBOHYD 151 151 POTENTIAL. FT CARBOHYD 156 156 POTENTIAL. FT CARBOHYD 199 199 POTENTIAL. FT CARBOHYD 345 345 POTENTIAL. FT CARBOHYD 360 360 POTENTIAL. FT CARBOHYD 378 378 POTENTIAL. FT CARBOHYD 396 396 POTENTIAL. FT CARBOHYD 450 450 POTENTIAL. FT CARBOHYD 470 470 POTENTIAL. FT CARBOHYD 556 556 POTENTIAL. SQ SEQUENCE 1115 AA; 123728 MW; 6532152 CN; MAKATSGAAG LGLKLILLLP LLGEAPLGLY FSRDAYWERL YVDQPAGTPL LYVHALRDAP GEVPSFRLGQ HLYGVYRTRL HENDWIRINE TTGLLYLNQS LDHSSWEQLS IRNGGFPLLT IFLQVFLGST AQREGECHWP GCTRVYFSFI NDTFPNCSSF KAQDLCIPET AVSSRVRENX PPGTFYHFHM LPVQFLCPNI SVKYSLLGGD SLPFRCDPDC LEVSTRWALD RELREKYVLE ALCIVAGPGA NKETVTLSFP VTVYDEDDSA PTFSGGVGTA SAVVEFKRKE GTVVATLQVF DADVVPASGE LVRRYTNTLL SGDSWAQQTF RVEHSPIETL VQVNNNSVRA TMHNYKLILN RSLSISESRV LQLAVLVNDS DFQGPGAGGI LVLHFNVSVL PVTLNLPRAY SFPVNKRARR YAQIGKVCVE NCQEFSGVSI QYKLQPSSIN CTALGVVTSP EDTSGTLFVN DTEALRRPEC TKLQYTVVAT DRQTRRQTQA SLVVTVEGTS ITEEVGCPKS CAVNKRRPEC EECGGLGSPT GRCEWRQGDG KGITRNFSTC SPSTRTCPDG HCDAVESRDA NICPQDCLRA DIVGGHERGE RQGIKAGYGI CNCFPDEKKC FCEPEDSQGP LCDALCRTII TAALFSLIIS ILLSIFCVCH HHKHGHKPPI ASAEMTFCRP AQGFPISYSS SGTRRPSLDS TENQVPVDSF KIPEDPKWEF PRKNLVLGKT LGEGEFGKVV XATAFRLKGR AGYTTVAVKX LKENASQSEL RDLLSEFNLL KQVNHPHVIK LYGACSQDGP LLLIVEYAKY GSLRGFLRDS RKIGPAYVSG GGSRNSSSLD HPDERVLTMG DLISFAWQIS RGMQYLAEMK LVHRDLAARN ILVAEGRKMK ISDFGLSRDV YEEDSYVKKS KGRIPVKWMA IESLFDHIYT TQSDVWSFGV LLWEIVTLGG NPYPGIPPER LFNLLKTGHR MERPDNCSEE MYRLMLQCWK QEPDKRPVFA DISKDLEKMM VKSRDYLDLA ASTPSDSLLY DDGLSEEETP LVDCNNAPLP RSLPSTWIEN KLYGMSDPNW PGESPVPLTR ADGTSTGFPR YANDSVYANW MVSPSAAKLM DTFDS //