ID   OR1D2_HUMAN             Reviewed;         312 AA.
AC   P34982; Q6IFL8; Q96RA4; Q9UM78;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2005, sequence version 2.
DT   03-AUG-2022, entry version 192.
DE   RecName: Full=Olfactory receptor 1D2;
DE   AltName: Full=Olfactory receptor 17-4;
DE            Short=OR17-4;
DE   AltName: Full=Olfactory receptor OR17-6;
DE   AltName: Full=Olfactory receptor-like protein HGMP07E;
GN   Name=OR1D2; Synonyms=OLFR1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT GLN-25.
RX   PubMed=8097991; DOI=10.1159/000133534;
RA   Schurmans S., Muscatelli F., Miot F., Mattei M.-G., Vassart G.,
RA   Parmentier M.;
RT   "The OLFR1 gene encoding the HGMP07E putative olfactory receptor maps to
RT   the 17p13-->p12 region of the human genome and reveals an MspI restriction
RT   fragment length polymorphism.";
RL   Cytogenet. Cell Genet. 63:200-204(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT GLN-25.
RX   PubMed=10673334; DOI=10.1006/geno.1999.6030;
RA   Glusman G., Sosinsky A., Ben-Asher E., Avidan N., Sonkin D., Bahar A.,
RA   Rosenthal A., Clifton S., Roe B., Ferraz C., Demaille J.G., Lancet D.;
RT   "Sequence, structure, and evolution of a complete human olfactory receptor
RT   gene cluster.";
RL   Genomics 63:227-245(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-214.
RA   Ferraz C., Demaille J.G.;
RT   "Sequence of cosmid ICRF105cF06137 of the human chromosome 17p13.3
RT   olfactory receptor gene cluster.";
RL   Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-282.
RX   PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA   Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA   Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA   Lehrach H., Lancet D., Shamir R.;
RT   "DEFOG: a practical scheme for deciphering families of genes.";
RL   Genomics 80:295-302(2002).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 118-282.
RX   PubMed=8004088; DOI=10.1093/hmg/3.2.229;
RA   Ben-Arie N., Lancet D., Taylor C., Khen M., Walker N., Ledbetter D.H.,
RA   Carrozzo R., Patel K., Sheer D., Lehrach H., North M.A.;
RT   "Olfactory receptor gene cluster on human chromosome 17: possible
RT   duplication of an ancestral receptor repertoire.";
RL   Hum. Mol. Genet. 3:229-235(1994).
RN   [7]
RP   FUNCTION IN SPERM CHEMOTAXIS, AND TISSUE SPECIFICITY.
RX   PubMed=12663925; DOI=10.1126/science.1080376;
RA   Spehr M., Gisselmann G., Poplawski A., Riffell J.A., Wetzel C.H.,
RA   Zimmer R.K., Hatt H.;
RT   "Identification of a testicular odorant receptor mediating human sperm
RT   chemotaxis.";
RL   Science 299:2054-2058(2003).
RN   [8]
RP   FUNCTION IN OLFACTORY RECEPTION, AND TISSUE SPECIFICITY.
RX   PubMed=15458659; DOI=10.1016/j.cub.2004.09.034;
RA   Spehr M., Schwane K., Heilmann S., Gisselmann G., Hummel T., Hatt H.;
RT   "Dual capacity of a human olfactory receptor.";
RL   Curr. Biol. 14:R832-R833(2004).
RN   [9]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [10]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
RN   [11]
RP   FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, AND MUTAGENESIS OF
RP   SER-230; SER-232; SER-239 AND THR-312.
RX   PubMed=16820410; DOI=10.1242/jcs.03046;
RA   Neuhaus E.M., Mashukova A., Barbour J., Wolters D., Hatt H.;
RT   "Novel function of beta-arrestin2 in the nucleus of mature spermatozoa.";
RL   J. Cell Sci. 119:3047-3056(2006).
CC   -!- FUNCTION: Odorant receptor which may be involved in sperm chemotaxis.
CC       Bourgeonal is a strong chemoattractant for sperm in vitro and is shown
CC       to be a strong agonist for OR1D2 in vitro. May also function in
CC       olfactory reception. {ECO:0000269|PubMed:12663925,
CC       ECO:0000269|PubMed:15458659, ECO:0000269|PubMed:16820410}.
CC   -!- INTERACTION:
CC       P34982; P34982: OR1D2; NbExp=3; IntAct=EBI-7590722, EBI-7590722;
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16820410};
CC       Multi-pass membrane protein {ECO:0000269|PubMed:16820410}. Note=In
CC       spermatazoa is localized in the midpiece and is translocated to the
CC       head region upon receptor stimulation with bourgeonal.
CC   -!- TISSUE SPECIFICITY: Expressed in testis. Expressed in spermatozoa (at
CC       protein level). Expressed in olfactory epithelium.
CC       {ECO:0000269|PubMed:12663925, ECO:0000269|PubMed:15458659,
CC       ECO:0000269|PubMed:16820410}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Protein Spotlight; Note=Love at first smell - Issue
CC       115 of March 2010;
CC       URL="https://web.expasy.org/spotlight/back_issues/115";
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR1D2";
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X65857; CAA46687.1; -; Genomic_DNA.
DR   EMBL; AF087917; AAF37310.1; -; Genomic_DNA.
DR   EMBL; BC069552; AAH69552.1; -; mRNA.
DR   EMBL; BC106735; AAI06736.1; -; mRNA.
DR   EMBL; BC106736; AAI06737.1; -; mRNA.
DR   EMBL; U53583; AAC99554.1; -; Genomic_DNA.
DR   EMBL; AF399535; AAK95020.1; -; Genomic_DNA.
DR   EMBL; U04678; AAA18343.1; -; Genomic_DNA.
DR   EMBL; BK004244; DAA04642.1; -; Genomic_DNA.
DR   CCDS; CCDS11019.1; -.
DR   PIR; A48413; A48413.
DR   PIR; I38471; I38471.
DR   RefSeq; NP_002539.2; NM_002548.2.
DR   AlphaFoldDB; P34982; -.
DR   SMR; P34982; -.
DR   BioGRID; 111035; 1.
DR   DIP; DIP-46308N; -.
DR   IntAct; P34982; 1.
DR   MINT; P34982; -.
DR   STRING; 9606.ENSP00000327585; -.
DR   GlyGen; P34982; 2 sites.
DR   iPTMnet; P34982; -.
DR   PhosphoSitePlus; P34982; -.
DR   BioMuta; OR1D2; -.
DR   DMDM; 67477446; -.
DR   PaxDb; P34982; -.
DR   PeptideAtlas; P34982; -.
DR   PRIDE; P34982; -.
DR   ProteomicsDB; 54966; -.
DR   ABCD; P34982; 8 sequenced antibodies.
DR   Antibodypedia; 58647; 140 antibodies from 20 providers.
DR   DNASU; 4991; -.
DR   Ensembl; ENST00000641064.1; ENSP00000493077.1; ENSG00000184166.3.
DR   Ensembl; ENST00000641833.1; ENSP00000493103.1; ENSG00000184166.3.
DR   GeneID; 4991; -.
DR   KEGG; hsa:4991; -.
DR   MANE-Select; ENST00000641833.1; ENSP00000493103.1; NM_002548.3; NP_002539.2.
DR   UCSC; uc010vrb.2; human.
DR   CTD; 4991; -.
DR   GeneCards; OR1D2; -.
DR   HGNC; HGNC:8183; OR1D2.
DR   HPA; ENSG00000184166; Tissue enhanced (brain).
DR   MIM; 164342; gene.
DR   neXtProt; NX_P34982; -.
DR   OpenTargets; ENSG00000184166; -.
DR   PharmGKB; PA32057; -.
DR   VEuPathDB; HostDB:ENSG00000184166; -.
DR   eggNOG; ENOG502T9JB; Eukaryota.
DR   GeneTree; ENSGT00940000160386; -.
DR   HOGENOM; CLU_012526_5_5_1; -.
DR   InParanoid; P34982; -.
DR   OMA; PFGFMII; -.
DR   OrthoDB; 971471at2759; -.
DR   PhylomeDB; P34982; -.
DR   TreeFam; TF337210; -.
DR   PathwayCommons; P34982; -.
DR   Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   SignaLink; P34982; -.
DR   BioGRID-ORCS; 4991; 258 hits in 665 CRISPR screens.
DR   GeneWiki; OR1D2; -.
DR   GenomeRNAi; 4991; -.
DR   Pharos; P34982; Tbio.
DR   PRO; PR:P34982; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; P34982; protein.
DR   Bgee; ENSG00000184166; Expressed in pancreatic ductal cell and 3 other tissues.
DR   ExpressionAtlas; P34982; baseline and differential.
DR   Genevisible; P34982; HS.
DR   GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; TAS:ProtInc.
DR   GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR   GO; GO:0004984; F:olfactory receptor activity; IDA:UniProtKB.
DR   GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IDA:UniProtKB.
DR   GO; GO:0007608; P:sensory perception of smell; TAS:ProtInc.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   GO; GO:0007338; P:single fertilization; IEA:UniProtKB-KW.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Chemotaxis; Disulfide bond; Fertilization;
KW   G-protein coupled receptor; Glycoprotein; Membrane; Olfaction; Receptor;
KW   Reference proteome; Sensory transduction; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..312
FT                   /note="Olfactory receptor 1D2"
FT                   /id="PRO_0000150418"
FT   TOPO_DOM        1..25
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..49
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        50..57
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..79
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        80..100
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..120
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        121..139
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..158
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        159..196
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        197..219
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        220..236
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        237..259
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        260..271
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..291
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        292..312
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        195
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        97..189
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         25
FT                   /note="R -> Q (in dbSNP:rs769423)"
FT                   /evidence="ECO:0000269|PubMed:10673334,
FT                   ECO:0000269|PubMed:8097991"
FT                   /id="VAR_019630"
FT   VARIANT         31
FT                   /note="F -> Y (in dbSNP:rs9916628)"
FT                   /id="VAR_057534"
FT   VARIANT         214
FT                   /note="V -> M (in dbSNP:rs55803944)"
FT                   /id="VAR_062008"
FT   VARIANT         240
FT                   /note="T -> I (in dbSNP:rs4300683)"
FT                   /id="VAR_057535"
FT   MUTAGEN         230
FT                   /note="S->A: Abolishes nuclear translocation of ARRB2; when
FT                   associated with A-232 and A-239."
FT                   /evidence="ECO:0000269|PubMed:16820410"
FT   MUTAGEN         232
FT                   /note="S->A: Abolishes nuclear translocation of ARRB2; when
FT                   associated with A-230 and A-239."
FT                   /evidence="ECO:0000269|PubMed:16820410"
FT   MUTAGEN         239
FT                   /note="S->A: Abolishes nuclear translocation of ARRB2; when
FT                   associated with A-230 and A-232."
FT                   /evidence="ECO:0000269|PubMed:16820410"
FT   MUTAGEN         312
FT                   /note="T->A: Abolishes nuclear translocation of ARRB2."
FT                   /evidence="ECO:0000269|PubMed:16820410"
SQ   SEQUENCE   312 AA;  35240 MW;  71B05367C0AA135B CRC64;
     MDGGNQSEGS EFLLLGMSES PEQQRILFWM FLSMYLVTVV GNVLIILAIS SDSRLHTPVY
     FFLANLSFTD LFFVTNTIPK MLVNLQSHNK AISYAGCLTQ LYFLVSLVAL DNLILAVMAY
     DRYVAICCPL HYTTAMSPKL CILLLSLCWV LSVLYGLIHT LLMTRVTFCG SRKIHYIFCE
     MYVLLRMACS NIQINHTVLI ATGCFIFLIP FGFVIISYVL IIRAILRIPS VSKKYKAFST
     CASHLGAVSL FYGTLCMVYL KPLHTYSVKD SVATVMYAVV TPMMNPFIYS LRNKDMHGAL
     GRLLDKHFKR LT
//