ID SPC2_CAEEL STANDARD; PRT; 180 AA. AC P34525; DT 01-FEB-1994 (Rel. 28, Created) DT 01-FEB-1994 (Rel. 28, Last sequence update) DT 15-JUL-1998 (Rel. 36, Last annotation update) DE PROBABLE MICROSOMAL SIGNAL PEPTIDASE 23 KDA SUBUNIT (EC 3.4.-.-) DE (SPC22/23). GN K12H4.4. OS Caenorhabditis elegans. OC Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; OC Rhabditidae; Peloderinae; Caenorhabditis. RN [1] RP SEQUENCE FROM N.A. RC STRAIN=BRISTOL N2; RX MEDLINE; 94150718. RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., RA Bonfield J., Burton J., Connell M., Copsey T., Cooper J., Coulson A., RA Craxton M., Dear S., Du Z., Durbin R., Favello A., Fraser A., RA Fulton L., Gardner A., Green P., Hawkins T., Hillier L., Jier M., RA Johnston L., Jones M., Kershaw J., Kirsten J., Laisster N., RA Latreille P., Lightning J., Lloyd C., Mortimore B., O'Callaghan M., RA Parsons J., Percy C., Rifken L., Roopra A., Saunders D., Shownkeen R., RA Sims M., Smaldon N., Smith A., Smith M., Sonnhammer E., Staden R., RA Sulston J., Thierry-Mieg J., Thomas K., Vaudin M., Vaughan K., RA Waterson R., Watson A., Weinstock L., Wilkinson-Sproat J., RA Wohldman P.; RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C. RT elegans."; RL Nature 368:32-38(1994). CC -!- FUNCTION: MICROSOMAL SIGNAL PEPTIDASE IS A MEMBRANE-BOUND CC ENDOPROTEINASE THAT REMOVES SIGNAL PEPTIDES FROM NASCENT CC PROTEINS AS THEY ARE TRANSLOCATED INTO THE LUMEN OF THE CC ENDOPLASMIC RETICULUM. CC -!- SUBCELLULAR LOCATION: TYPE II MEMBRANE PROTEIN. MICROSOMAL CC (POTENTIAL). CC -!- SIMILARITY: TO VERTEBRATES SPC22/23 AND TO YEAST SPC3. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L14331; AAA28096.1; -. DR PIR; S44854; S44854. DR WORMPEP; K12H4.4; CE00269. KW Glycoprotein; Hydrolase; Microsome; Endoplasmic reticulum; KW Transmembrane; Protease; Signal-anchor. FT DOMAIN 1 12 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 13 33 SIGNAL-ANCHOR (TYPE-II MEMBRANE PROTEIN) FT (POTENTIAL). FT DOMAIN 34 180 LUMENAL (POTENTIAL). SQ SEQUENCE 180 AA; 20687 MW; 4CAEB791F3374EB8 CRC64; MHNLLSRANA LLAFTLWVMA AVTAACFLST VFLDYTVPTK LTVNDVKVRN VVDYATDEQQ ADLATLNFNL KVDFSKIFNW NVKQLFVYLV AEYKSKVNEV NQVVLWDRIV ERADRVVMDE IGVKSKYYFL DDGTNLLNHK NVTFVLRYNV IPNSGYLRLV QSSDQVVVPF PTTYTTTRRS //