ID SP22_CAEEL STANDARD; PRT; 180 AA. AC P34525; DT 01-FEB-1994 (Rel. 28, Created) DT 01-FEB-1994 (Rel. 28, Last sequence update) DT 15-JUN-2002 (Rel. 41, Last annotation update) DE Probable microsomal signal peptidase 22 kDa subunit (EC 3.4.-.-) DE (SPase 22 kDa subunit) (SPC22). GN K12H4.4. OS Caenorhabditis elegans. OC Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; OC Rhabditidae; Peloderinae; Caenorhabditis. OX NCBI_TaxID=6239; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=Bristol N2; RX MEDLINE=94150718; PubMed=7906398; RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., RA Bonfield J., Burton J., Connell M., Copsey T., Cooper J., Coulson A., RA Craxton M., Dear S., Du Z., Durbin R., Favello A., Fraser A., RA Fulton L., Gardner A., Green P., Hawkins T., Hillier L., Jier M., RA Johnston L., Jones M., Kershaw J., Kirsten J., Laisster N., RA Latreille P., Lightning J., Lloyd C., Mortimore B., O'Callaghan M., RA Parsons J., Percy C., Rifken L., Roopra A., Saunders D., Shownkeen R., RA Sims M., Smaldon N., Smith A., Smith M., Sonnhammer E., Staden R., RA Sulston J., Thierry-Mieg J., Thomas K., Vaudin M., Vaughan K., RA Waterston R., Watson A., Weinstock L., Wilkinson-Sproat J., RA Wohldman P.; RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C. RT elegans."; RL Nature 368:32-38(1994). CC -!- FUNCTION: MICROSOMAL SIGNAL PEPTIDASE IS A MEMBRANE-BOUND CC ENDOPROTEINASE THAT REMOVES SIGNAL PEPTIDES FROM NASCENT CC PROTEINS AS THEY ARE TRANSLOCATED INTO THE LUMEN OF THE CC ENDOPLASMIC RETICULUM (By similarity). CC -!- SUBUNIT: COMPLEX OF FIVE DIFFERENT PROTEINS: SPC25, SPC22/23, CC SPC21, SPC18, AND SPC12 (By similarity). CC -!- SUBCELLULAR LOCATION: Type II membrane protein. Microsomal CC (Potential). CC -!- SIMILARITY: BELONGS TO THE SPC22 FAMILY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L14331; AAA28096.1; -. DR PIR; S44854; S44854. DR WormPep; K12H4.4; CE00269. KW Hydrolase; Protease; Microsome; Endoplasmic reticulum; Transmembrane; KW Signal-anchor; Glycoprotein. FT DOMAIN 1 12 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 13 33 SIGNAL-ANCHOR (TYPE-II MEMBRANE PROTEIN) FT (POTENTIAL). FT DOMAIN 34 180 LUMENAL (POTENTIAL). FT CARBOHYD 141 141 N-LINKED (GLCNAC...) (POTENTIAL). SQ SEQUENCE 180 AA; 20687 MW; 4CAEB791F3374EB8 CRC64; MHNLLSRANA LLAFTLWVMA AVTAACFLST VFLDYTVPTK LTVNDVKVRN VVDYATDEQQ ADLATLNFNL KVDFSKIFNW NVKQLFVYLV AEYKSKVNEV NQVVLWDRIV ERADRVVMDE IGVKSKYYFL DDGTNLLNHK NVTFVLRYNV IPNSGYLRLV QSSDQVVVPF PTTYTTTRRS //