ID MTSS1_CAEEL Reviewed; 170 AA. AC P34496; DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1995, sequence version 2. DT 19-JAN-2010, entry version 64. DE RecName: Full=Mitochondrial single stranded DNA binding protein 1; GN Name=mtss-1; ORFNames=PAR2.1; OS Caenorhabditis elegans. OC Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; OC Rhabditidae; Peloderinae; Caenorhabditis. OX NCBI_TaxID=6239; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Bristol N2; RX MEDLINE=94150718; PubMed=7906398; DOI=10.1038/368032a0; RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., RA Bonfield J., Burton J., Connell M., Copsey T., Cooper J., Coulson A., RA Craxton M., Dear S., Du Z., Durbin R., Favello A., Fraser A., RA Fulton L., Gardner A., Green P., Hawkins T., Hillier L., Jier M., RA Johnston L., Jones M., Kershaw J., Kirsten J., Laisster N., RA Latreille P., Lightning J., Lloyd C., Mortimore B., O'Callaghan M., RA Parsons J., Percy C., Rifken L., Roopra A., Saunders D., Shownkeen R., RA Sims M., Smaldon N., Smith A., Smith M., Sonnhammer E., Staden R., RA Sulston J., Thierry-Mieg J., Thomas K., Vaudin M., Vaughan K., RA Waterston R., Watson A., Weinstock L., Wilkinson-Sproat J., RA Wohldman P.; RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C. RT elegans."; RL Nature 368:32-38(1994). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Bristol N2; RX MEDLINE=99069613; PubMed=9851916; DOI=10.1126/science.282.5396.2012; RG The C. elegans sequencing consortium; RT "Genome sequence of the nematode C. elegans: a platform for RT investigating biology."; RL Science 282:2012-2018(1998). RN [3] RP FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND DISRUPTION RP PHENOTYPE. RX PubMed=17900564; DOI=10.1016/j.yexcr.2007.08.015; RA Sugimoto T., Mori C., Takanami T., Sasagawa Y., Saito R., Ichiishi E., RA Higashitani A.; RT "Caenorhabditis elegans par2.1/mtssb-1 is essential for mitochondrial RT DNA replication and its defect causes comprehensive transcriptional RT alterations including a hypoxia response."; RL Exp. Cell Res. 314:103-114(2008). CC -!- FUNCTION: Has a role in germline cell development and CC proliferation which affects the frequency of apoptosis. Required CC for mitochondrial DNA replication and transcription and fertility. CC -!- INTERACTION: CC Q17746:-; NbExp=1; IntAct=EBI-325500, EBI-313792; CC Q09587:nhr-22; NbExp=1; IntAct=EBI-325500, EBI-323124; CC Q22847:T28C6.7; NbExp=1; IntAct=EBI-325500, EBI-316760; CC Q2XMY4:W08G11.3; NbExp=1; IntAct=EBI-325500, EBI-325506; CC -!- TISSUE SPECIFICITY: Expressed in eggs. CC -!- DEVELOPMENTAL STAGE: Expressed at low levels in L1 larvae and CC increases at the L3 stage to the adult stage. CC -!- DISRUPTION PHENOTYPE: Reduced mitochondrial replication, CC transcriptional hypoxia response, sterility, arrest of germline CC cell proliferation, reduced frequency of apoptosis in the CC germline. CC -!- SIMILARITY: Contains 1 SSB domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U00025; AAA50616.1; -; Genomic_DNA. DR PIR; S44857; S44857. DR RefSeq; NP_498935.1; -. DR UniGene; Cel.10245; -. DR SMR; P34496; 51-159. DR DIP; DIP-25867N; -. DR IntAct; P34496; 4. DR STRING; P34496; -. DR Ensembl; PAR2.1.1; PAR2.1.1; PAR2.1; Caenorhabditis elegans. DR Ensembl; PAR2.1.2; PAR2.1.2; PAR2.1; Caenorhabditis elegans. DR GeneID; 187502; -. DR KEGG; cel:PAR2.1; -. DR CTD; 187502; -. DR WormBase; WBGene00019800; mtss-1. DR WormPep; PAR2.1; CE00768. DR eggNOG; KOG1653; -. DR HOGENOM; HBG382015; -. DR InParanoid; P34496; -. DR OMA; CMSLTSK; -. DR PhylomeDB; P34496; -. DR NextBio; 935490; -. DR ArrayExpress; P34496; -. DR GO; GO:0005515; F:protein binding; IPI:IntAct. DR GO; GO:0003697; F:single-stranded DNA binding; IEA:InterPro. DR GO; GO:0006260; P:DNA replication; IEA:InterPro. DR InterPro; IPR012340; NA-bd_OB-fold. DR InterPro; IPR016027; NA-bd_OB-fold-like. DR InterPro; IPR000424; Primosome_PriB/ssb. DR InterPro; IPR011344; ssDNA_bd. DR Gene3D; G3DSA:2.40.50.140; OB_NA_bd_sub; 1. DR PANTHER; PTHR10302; Single_strand_bd; 1. DR Pfam; PF00436; SSB; 1. DR PROSITE; PS50935; SSB; 1. PE 1: Evidence at protein level; KW Complete proteome; DNA-binding. FT CHAIN 1 170 Mitochondrial single stranded DNA binding FT protein 1. FT /FTId=PRO_0000095993. FT DOMAIN 54 160 SSB. SQ SEQUENCE 170 AA; 19182 MW; D1FA3DEA8F94ABE1 CRC64; MLRSLSTISK STVRCMSLTS KMAAEQPSKQ EVDDLFAEKP QHHNPEQRRH AYSVNKVELV GGVALDPLYK TGRNGKPYLI FNIITNSYFK QQDGTTLDQT ERHAVSVFGK QAEILSKTIK KGSRLMVQGR LHYSGGQKDE QGNRTQRNTY IIAQTVQPLA RAARENPDQH //