ID COAC_DICDI Reviewed; 146 AA. AC P34121; DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1994, sequence version 1. DT 12-JUN-2007, entry version 38. DE Coactosin (Cytoskeletal p17 protein) (Cyclic AMP-regulated protein DE p16). GN Name=coaA; Synonyms=p17; OS Dictyostelium discoideum (Slime mold). OC Eukaryota; Mycetozoa; Dictyosteliida; Dictyostelium. OX NCBI_TaxID=44689; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 128-133. RC STRAIN=AX2; RX MEDLINE=94123348; PubMed=8293475; RA de Hostos E.L., Bradtke B., Lottspeich F., Gerisch G.; RT "Coactosin, a 17 kDa F-actin binding protein from Dictyostelium RT discoideum."; RL Cell Motil. Cytoskeleton 26:181-191(1993). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=AX3; RA Sastry R., Abbruzzi G., Tauber A.I.; RL Submitted (OCT-1993) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Binds to F-actin in a calcium independent manner. Binds CC to the filaments along their length. CC -!- SUBCELLULAR LOCATION: Cytoplasm. CC -!- PTM: The N-terminus is blocked. CC -!- SIMILARITY: Belongs to the actin-binding proteins ADF family. CC Coactosin subfamily. CC -!- SIMILARITY: Contains 1 ADF-H domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X61797; CAA43899.1; -; mRNA. DR EMBL; M92992; AAA33174.1; -; mRNA. DR PIR; S17111; S17111. DR SWISS-2DPAGE; P34121; DICTY. DR DictyBase; DDB0001835; coaA. DR GO; GO:0005813; C:centrosome; IDA:DictyBase. DR GO; GO:0045335; C:phagocytic vesicle; IDA:DictyBase. DR GO; GO:0051015; F:actin filament binding; IDA:DictyBase. DR GO; GO:0030833; P:regulation of actin filament polymerization; IDA:DictyBase. DR InterPro; IPR002108; cofln_actin_bd. DR Pfam; PF00241; Cofilin_ADF; 1. DR SMART; SM00102; ADF; 1. DR PROSITE; PS51263; ADF_H; 1. KW Actin-binding; Cytoskeleton; Direct protein sequencing. FT CHAIN 1 146 Coactosin. FT /FTId=PRO_0000214956. FT DOMAIN 1 132 ADF-H. SQ SEQUENCE 146 AA; 16004 MW; EE7AE2432D8FE1D9 CRC64; MADVSSTELK AAYDEVLADS NDTNWCLFKY EGKNKIVLSG KGSGGFAELA QEINQPSERL YAYLRVVSGD DESKRSKFVF ISWCGEEVGP LAKANVSVHK ASVKQVIKNI GVEVHYTVAD DLNEEELMTK VRKSSGADYS GNKSTN //