ID RANG_MOUSE STANDARD; PRT; 203 AA. AC P34022; P34023; DT 01-FEB-1994 (Rel. 28, Created) DT 01-FEB-1994 (Rel. 28, Last sequence update) DT 30-MAY-2000 (Rel. 39, Last annotation update) DE RAN-SPECIFIC GTPASE-ACTIVATING PROTEIN (RAN BINDING PROTEIN 1) DE (RANBP1). GN RANBP1 OR HTF9A OR HTF9-A. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=94077185; PubMed=8255297; RA Coutavas E., Ren M., Oppenheim J.D., D'Eustachio P., Rush M.G.; RT "Characterization of proteins that interact with the cell-cycle RT regulatory protein Ran/TC4."; RL Nature 366:585-587(1993). RN [2] RP SEQUENCE FROM N.A. RC STRAIN=C57BL; RX MEDLINE=91365246; PubMed=1889746; RA Bressan A., Somma M.P., Lewis J., Santolamazza C., Copeland N.G., RA Gilbert D.J., Jenkins N.A., Lavia P.; RT "Characterization of the opposite-strand genes from the mouse RT bidirectionally transcribed HTF9 locus."; RL Gene 103:201-209(1991). RN [3] RP SEQUENCE FROM N.A. RC STRAIN=C57BL; RA Lavia P.; RL Submitted (XXX-1994) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: INHIBITS GTP EXCHANGE ON RAN. FORMS A RAN-GTP-RANBP1 CC TRIMERIC COMPLEX. INCREASE GTP HYDROLYSIS INDUCED BY THE RAN CC GTPASE ACTIVATING PROTEIN RANGAP1. MAY ACT IN AN INTRACELLULAR CC SIGNALING PATHWAY WHICH MAY CONTROL THE PROGRESSION THROUGH THE CC CELL CYCLE BY REGULATING THE TRANSPORT OF PROTEIN AND NUCLEIC CC ACIDS ACROSS THE NUCLEAR MEMBRANE. CC -!- SIMILARITY: TO OTHER EUKARYOTIC RANBP1. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X56046; CAA39517.1; -. DR EMBL; L25255; AAA16195.1; -. DR EMBL; X56045; CAA39516.1; -. DR PIR; JQ1973; JQ1973. DR MGD; MGI:96269; Ranbp1. DR InterPro; IPR000156; -. DR Pfam; PF00638; Ran_BP1; 1. KW GTPase activation. FT CONFLICT 9 9 E -> A (IN REF. 2). FT CONFLICT 22 24 NHD -> TTH (IN REF. 2). FT CONFLICT 33 33 V -> L (IN REF. 3). FT CONFLICT 70 72 RGT -> PRH (IN REF. 2). FT CONFLICT 126 126 A -> T (IN REF. 2 AND 3). SQ SEQUENCE 203 AA; 23582 MW; 5D70158B8AC9FC9D CRC64; MAAAKDSHED HDTSTENADE SNHDPQFEPI VSVPEQEIKT LEEDEEELFK MRAKLFRFAS ENDLPEWKER GTGDVKLLKH KEKGTIRLLM RRDKTLKICA NHYITPMMEL KPNAGSDRAW VWNTHADFAD ECPKPELLAI RFLNAENAQK FKTKFEECRK EIEEREKKGP GKNDNAEKVA EKLEALSVRE AREEAEEKSE EKQ //