ID UTS2_PELRI Reviewed; 127 AA. AC P33715; Q9PSX6; DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot. DT 01-DEC-2000, sequence version 2. DT 01-OCT-2014, entry version 55. DE RecName: Full=Urotensin-2; DE AltName: Full=Urotensin II; DE Short=U-II; DE Short=UII; DE Flags: Precursor; GN Name=UTS2; OS Pelophylax ridibundus (Marsh frog) (Rana ridibunda). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; OC Pelophylax. OX NCBI_TaxID=8406; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Brain; RX PubMed=9861051; DOI=10.1073/pnas.95.26.15803; RA Coulouarn Y., Lihrmann I., Jegou S., Anouar Y., Tostivint H., RA Beauvillain J.-C., Conlon J.M., Bern H.A., Vaudry H.; RT "Cloning of the cDNA encoding the urotensin II precursor in frog and RT human reveals intense expression of the urotensin II gene in RT motoneurons of the spinal cord."; RL Proc. Natl. Acad. Sci. U.S.A. 95:15803-15808(1998). RN [2] RP PROTEIN SEQUENCE OF 115-127. RC TISSUE=Brain; RX PubMed=1445302; DOI=10.1016/0006-291X(92)91095-8; RA Conlon J.M., O'Harte F., Smith D.D., Tonon M.-C., Vaudry H.; RT "Isolation and primary structure of urotensin II from the brain of a RT tetrapod, the frog Rana ridibunda."; RL Biochem. Biophys. Res. Commun. 188:578-583(1992). CC -!- FUNCTION: Involved in smooth muscle stimulating and ion mobilizing CC activities. It has a suggested role as a corticotropin-releasing CC factor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Central nervous system. Spinal cord. CC -!- SIMILARITY: Belongs to the urotensin-2 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF104117; AAD13069.1; -; mRNA. DR PIR; PQ0445; PQ0445. DR HOVERGEN; HBG065793; -. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0008217; P:regulation of blood pressure; IEA:InterPro. DR GO; GO:0042312; P:regulation of vasodilation; IEA:InterPro. DR InterPro; IPR001483; Urotensin_II. DR Pfam; PF02083; Urotensin_II; 1. DR PROSITE; PS00984; UROTENSIN_II; 1. PE 1: Evidence at protein level; KW Cleavage on pair of basic residues; Direct protein sequencing; KW Disulfide bond; Hormone; Secreted; Signal. FT SIGNAL 1 16 {ECO:0000255}. FT PROPEP 17 111 FT /FTId=PRO_0000036344. FT PEPTIDE 115 127 Urotensin-2. FT /FTId=PRO_0000036345. FT DISULFID 121 126 SQ SEQUENCE 127 AA; 14732 MW; FC26BC90E00C082E CRC64; MSKLFFCCLI LAGSFCSFRS LPIIVPSKGS LRLSESALDF GDLKSWDDET RLLRNLPMFV DKEAERDAED IFSKEGFGLD AYNMDDKEEL FDKHPRISLL SRLQSKDRKQ FKKRAGNLSE CFWKYCV //