ID UR2_RANRI STANDARD; PRT; 127 AA. AC P33715; Q9PSX6; DT 01-FEB-1994 (Rel. 28, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Urotensin II precursor (U-II) (UII). GN UTS2. OS Rana ridibunda (Laughing frog) (Marsh frog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Rana. OX NCBI_TaxID=8406; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Brain; RX MEDLINE=99080095; PubMed=9861051; RA Coulouarn Y., Lihrmann I., Jegou S., Anouar Y., Tostivint H., RA Beauvillain J.C., Conlon J.M., Bern H.A., Vaudry H.; RT "Cloning of the cDNA encoding the urotensin II precursor in frog and RT human reveals intense expression of the urotensin II gene in RT motoneurons of the spinal cord."; RL Proc. Natl. Acad. Sci. U.S.A. 95:15803-15808(1998). RN [2] RP SEQUENCE OF 115-127. RC TISSUE=Brain; RX MEDLINE=93075134; PubMed=1445302; RA Conlon J.M., O'Harte F., Smith D.D., Tonon M.-C., Vaudry H.; RT "Isolation and primary structure of urotensin II from the brain of a RT tetrapod, the frog Rana ridibunda."; RL Biochem. Biophys. Res. Commun. 188:578-583(1992). CC -!- FUNCTION: INVOLVED IN SMOOTH MUSCLE STIMULATING AND ION CC MOBILIZING ACTIVITIES. IT HAS A SUGGESTED ROLE AS A CC CORTICOTROPIN-RELEASING FACTOR. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Central nervous system. Spinal cord. CC -!- SIMILARITY: Belongs to the urotensin 2 family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF104117; AAD13069.1; -. DR InterPro; IPR001483; Urotensin_II. DR Pfam; PF02083; Urotensin_II; 1. DR PROSITE; PS00984; UROTENSIN_II; 1. KW Hormone; Cleavage on pair of basic residues; Signal. FT SIGNAL 1 16 POTENTIAL. FT PROPEP 17 111 FT PEPTIDE 115 127 UROTENSIN II. FT DISULFID 121 126 SQ SEQUENCE 127 AA; 14732 MW; FC26BC90E00C082E CRC64; MSKLFFCCLI LAGSFCSFRS LPIIVPSKGS LRLSESALDF GDLKSWDDET RLLRNLPMFV DKEAERDAED IFSKEGFGLD AYNMDDKEEL FDKHPRISLL SRLQSKDRKQ FKKRAGNLSE CFWKYCV //