ID OPRM_RAT Reviewed; 398 AA. AC P33535; Q62846; Q64064; Q64120; DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1994, sequence version 1. DT 13-JUL-2010, entry version 88. DE RecName: Full=Mu-type opioid receptor; DE Short=M-OR-1; DE Short=MOR-1; DE AltName: Full=Opioid receptor B; GN Name=Oprm1; Synonyms=Ror-b; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Brain; RX MEDLINE=93351652; PubMed=8394245; DOI=10.1016/0014-5793(93)81011-N; RA Fukuda K., Kato S., Mori K., Nishi M., Takeshima H.; RT "Primary structures and expression from cDNAs of rat opioid receptor RT delta- and mu-subtypes."; RL FEBS Lett. 327:311-314(1993). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Brain; RX MEDLINE=94052137; PubMed=8234282; DOI=10.1073/pnas.90.21.10230; RA Wang J.-B., Imai Y., Epler M.C., Gregor P., Spivak C., Uhl G.R.; RT "Mu opiate receptor: cDNA cloning and expression."; RL Proc. Natl. Acad. Sci. U.S.A. 90:10230-10234(1993). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Brain; RX MEDLINE=93341493; PubMed=8393525; RA Chen Y., Mestek A., Liu J., Hurley J.A., Yu L.; RT "Molecular cloning and functional expression of a mu-opioid receptor RT from rat brain."; RL Mol. Pharmacol. 44:8-12(1993). RN [4] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=Sprague-Dawley; TISSUE=Brain; RA Bunzow J.R., Grandy D.K., Kelly M.; RL Submitted (SEP-1993) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=Sprague-Dawley; TISSUE=Olfactory bulb; RX MEDLINE=94059560; PubMed=8240812; DOI=10.1016/0896-6273(93)90120-G; RA Thompson R.C., Mansour A., Akil H., Watson S.J.; RT "Cloning and pharmacological characterization of a rat mu opioid RT receptor."; RL Neuron 11:903-913(1993). RN [6] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Brain; RX MEDLINE=94246380; PubMed=8189219; RA Zastawny R.L., George S.R., Nguyen T., Cheng R., Tsatsos J., RA Briones-Urbina R., O'Dowd B.F.; RT "Cloning, characterization, and distribution of a mu-opioid receptor RT in rat brain."; RL J. Neurochem. 62:2099-2105(1994). RN [7] RP NUCLEOTIDE SEQUENCE [MRNA] OF 101-340. RC TISSUE=Macrophage; RX MEDLINE=95251654; PubMed=7733926; DOI=10.1006/bbrc.1995.1538; RA Sedqi M., Roy S., Ramakrishnan S., Elde R., Loh H.H.; RT "Complementary DNA cloning of a mu-opioid receptor from rat peritoneal RT macrophages."; RL Biochem. Biophys. Res. Commun. 209:563-574(1995). RN [8] RP NUCLEOTIDE SEQUENCE [MRNA] OF 356-391. RX MEDLINE=95172221; PubMed=7532594; DOI=10.1016/0014-5793(95)00028-8; RA Zimprich A., Simon T., Hoellt V.; RT "Cloning and expression of an isoform of the rat mu opioid receptor RT (rMOR1B) which differs in agonist induced desensitization from RT rMOR1."; RL FEBS Lett. 359:142-146(1995). CC -!- FUNCTION: Inhibits neurotransmitter release by reducing calcium CC ion currents and increasing potassium ion conductance. Receptor CC for beta-endorphin. CC -!- SUBUNIT: Forms a complex with G(alpha)z/i2 subunits and the RGSZ CC proteins, RGSZ17 and RGSZ20. The formation of this complex results CC in mu-opioid receptor desensitization. Interacts with RGSZ17 and CC RGSZ20 (By similarity). CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Brain. Is expressed in the cerebral cortex, CC caudate putamen, nucleus accumbens, septal nuclei, thalamus, CC hippocampus, and habenula. Not detected in cerebellum. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; D16349; BAA03852.1; -; mRNA. DR EMBL; L20684; AAA41643.1; -; mRNA. DR EMBL; L13069; AAA41630.1; -; mRNA. DR EMBL; U02083; AAA70049.1; -; mRNA. DR EMBL; L22455; AAA16075.1; -; mRNA. DR EMBL; U35424; AAA79180.1; -; mRNA. DR EMBL; S77863; -; NOT_ANNOTATED_CDS; mRNA. DR EMBL; S75669; AAB33530.2; -; mRNA. DR IPI; IPI00655338; -. DR PIR; I56504; I56504. DR PIR; I56517; I56517. DR PIR; S69010; S69010. DR RefSeq; NP_001033686.1; -. DR RefSeq; NP_001033689.1; -. DR RefSeq; NP_001033690.1; -. DR RefSeq; NP_037203.1; -. DR UniGene; Rn.10118; -. DR SMR; P33535; 46-350. DR STRING; P33535; -. DR PhosphoSite; P33535; -. DR Ensembl; ENSRNOT00000051837; ENSRNOP00000051290; ENSRNOG00000018191; Rattus norvegicus. DR Ensembl; ENSRNOT00000066989; ENSRNOP00000061636; ENSRNOG00000018191; Rattus norvegicus. DR GeneID; 25601; -. DR KEGG; rno:25601; -. DR UCSC; NM_013071; rat. DR CTD; 25601; -. DR RGD; 3234; Oprm1. DR eggNOG; roNOG08631; -. DR HOVERGEN; HBG106919; -. DR OrthoDB; EOG91VNN8; -. DR NextBio; 607309; -. DR ArrayExpress; P33535; -. DR Genevestigator; P33535; -. DR GermOnline; ENSRNOG00000018191; Rattus norvegicus. DR GO; GO:0032839; C:dendrite cytoplasm; IDA:RGD. DR GO; GO:0032590; C:dendrite membrane; IDA:RGD. DR GO; GO:0005925; C:focal adhesion; IDA:RGD. DR GO; GO:0005887; C:integral to plasma membrane; TAS:RGD. DR GO; GO:0005624; C:membrane fraction; IDA:RGD. DR GO; GO:0045121; C:membrane raft; IDA:RGD. DR GO; GO:0043204; C:perikaryon; IDA:RGD. DR GO; GO:0004988; F:mu-opioid receptor activity; IDA:RGD. DR GO; GO:0005515; F:protein binding; IDA:RGD. DR GO; GO:0002438; P:acute inflammatory response to antigenic st...; IEP:RGD. DR GO; GO:0031635; P:inhibition of adenylate cyclase activity by...; IDA:RGD. DR GO; GO:0032100; P:positive regulation of appetite; IMP:RGD. DR GO; GO:0060079; P:regulation of excitatory postsynaptic membr...; IDA:RGD. DR GO; GO:0051930; P:regulation of sensory perception of pain; IDA:RGD. DR GO; GO:0042220; P:response to cocaine; IEP:RGD. DR GO; GO:0032094; P:response to food; IEP:RGD. DR GO; GO:0070848; P:response to growth factor stimulus; IEP:RGD. DR GO; GO:0032496; P:response to lipopolysaccharide; IEP:RGD. DR GO; GO:0043278; P:response to morphine; IEP:RGD. DR GO; GO:0042060; P:wound healing; IEP:RGD. DR InterPro; IPR000276; 7TM_GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_supfam. DR InterPro; IPR000105; Mu_opioid_rcpt. DR InterPro; IPR001418; Opioid_rcpt. DR PANTHER; PTHR19264:SF229; Mu_opioid_rcpt; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00537; MUOPIOIDR. DR PRINTS; PR00384; OPIOIDR. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 2: Evidence at transcript level; KW Cell membrane; Disulfide bond; G-protein coupled receptor; KW Glycoprotein; Lipoprotein; Membrane; Palmitate; Phosphoprotein; KW Receptor; Transducer; Transmembrane. FT CHAIN 1 398 Mu-type opioid receptor. FT /FTId=PRO_0000069978. FT TOPO_DOM 1 64 Extracellular (Potential). FT TRANSMEM 65 94 Helical; Name=1; (Potential). FT TOPO_DOM 95 103 Cytoplasmic (Potential). FT TRANSMEM 104 121 Helical; Name=2; (Potential). FT TOPO_DOM 122 143 Extracellular (Potential). FT TRANSMEM 144 163 Helical; Name=3; (Potential). FT TOPO_DOM 164 193 Cytoplasmic (Potential). FT TRANSMEM 194 209 Helical; Name=4; (Potential). FT TOPO_DOM 210 234 Extracellular (Potential). FT TRANSMEM 235 257 Helical; Name=5; (Potential). FT TOPO_DOM 258 280 Cytoplasmic (Potential). FT TRANSMEM 281 303 Helical; Name=6; (Potential). FT TOPO_DOM 304 311 Extracellular (Potential). FT TRANSMEM 312 328 Helical; Name=7; (Potential). FT TOPO_DOM 329 398 Cytoplasmic (Potential). FT LIPID 351 351 S-palmitoyl cysteine (Potential). FT CARBOHYD 9 9 N-linked (GlcNAc...) (Potential). FT CARBOHYD 31 31 N-linked (GlcNAc...) (Potential). FT CARBOHYD 38 38 N-linked (GlcNAc...) (Potential). FT CARBOHYD 46 46 N-linked (GlcNAc...) (Potential). FT CARBOHYD 53 53 N-linked (GlcNAc...) (Potential). FT DISULFID 140 217 By similarity. FT CONFLICT 237 237 F -> G (in Ref. 6; AAA79180). FT CONFLICT 245 245 V -> I (in Ref. 3, 4 and 7). FT CONFLICT 387 391 LENLE -> KIVLF (in Ref. 8). SQ SEQUENCE 398 AA; 44494 MW; 9C916DE7C1C33743 CRC64; MDSSTGPGNT SDCSDPLAQA SCSPAPGSWL NLSHVDGNQS DPCGLNRTGL GGNDSLCPQT GSPSMVTAIT IMALYSIVCV VGLFGNFLVM YVIVRYTKMK TATNIYIFNL ALADALATST LPFQSVNYLM GTWPFGTILC KIVISIDYYN MFTSIFTLCT MSVDRYIAVC HPVKALDFRT PRNAKIVNVC NWILSSAIGL PVMFMATTKY RQGSIDCTLT FSHPTWYWEN LLKICVFIFA FIMPVLIITV CYGLMILRLK SVRMLSGSKE KDRNLRRITR MVLVVVAVFI VCWTPIHIYV IIKALITIPE TTFQTVSWHF CIALGYTNSC LNPVLYAFLD ENFKRCFREF CIPTSSTIEQ QNSTRVRQNT REHPSTANTV DRTNHQLENL EAETAPLP //