ID OPRM_RAT STANDARD; PRT; 398 AA. AC P33535; Q64064; Q62846; Q64120; DT 01-FEB-1994 (REL. 28, CREATED) DT 01-FEB-1994 (REL. 28, LAST SEQUENCE UPDATE) DT 15-JUL-1998 (REL. 36, LAST ANNOTATION UPDATE) DE MU-TYPE OPIOID RECEPTOR (MOR-1) (OPIOID RECEPTOR B) (MUOR1). GN OPRM1 OR ROR-B. OS RATTUS NORVEGICUS (RAT). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; MAMMALIA; EUTHERIA; OC RODENTIA; SCIUROGNATHI; MURIDAE; MURINAE; RATTUS. RN [1] RP SEQUENCE FROM N.A. RC TISSUE=BRAIN; RX MEDLINE; 93351652. RA FUKUDA K., KATO S., MORI K., NISHI M., TAKESHIMA H.; RT "Primary structures and expression from cDNAs of rat opioid receptor RT delta- and mu-subtypes."; RL FEBS LETT. 327:311-314(1993). RN [2] RP SEQUENCE FROM N.A. RC TISSUE=BRAIN; RX MEDLINE; 94052137. RA WANG J.-B., IMAI Y., EPLER M.C., GREGOR P., SPIVAK C., UHL G.R.; RT "Mu opiate receptor: cDNA cloning and expression."; RL PROC. NATL. ACAD. SCI. U.S.A. 90:10230-10234(1993). RN [3] RP SEQUENCE FROM N.A. RC TISSUE=BRAIN; RX MEDLINE; 93341493. RA CHEN Y., MESTEK A., LIU J., HURLEY J.A., YU L.; RT "Molecular cloning and functional expression of a mu-opioid receptor RT from rat brain."; RL MOL. PHARMACOL. 44:8-12(1993). RN [4] RP SEQUENCE FROM N.A. RC STRAIN=SPRAGUE-DAWLEY; TISSUE=BRAIN; RA BUNZOW J.R., GRANDY D.K., KELLY M.; RL SUBMITTED (SEP-1993) TO EMBL/GENBANK/DDBJ DATA BANKS. RN [5] RP SEQUENCE FROM N.A. RC STRAIN=SPRAGUE-DAWLEY; TISSUE=OLFACTORY BULB; RX MEDLINE; 94059560. RA THOMPSON R.C., MANSOUR A., AKIL H., WATSON S.J.; RT "Cloning and pharmacological characterization of a rat mu opioid RT receptor."; RL NEURON 11:903-913(1993). RN [6] RP SEQUENCE FROM N.A. RC TISSUE=BRAIN; RX MEDLINE; 94246380. RA ZASTAWNY R.L., GEORGE S.R., NGUYEN T., CHENG R., TSATSOS J., RA BRIONES-URBINA R., O'DOWD B.F.; RT "Cloning, characterization, and distribution of a mu-opioid receptor RT in rat brain."; RL J. NEUROCHEM. 62:2099-2105(1994). RN [7] RP SEQUENCE OF 101-340 FROM N.A. RC TISSUE=MACROPHAGE; RX MEDLINE; 95251654. RA SEDQI M., ROY S., RAMAKRISHNAN S., ELDE R., LOH H.H.; RT "Complementary DNA cloning of a mu-opioid receptor from rat RT peritoneal macrophages."; RL BIOCHEM. BIOPHYS. RES. COMMUN. 209:563-574(1995). RN [8] RP SEQUENCE OF 356-391 FROM N.A. RX MEDLINE; 95172221. RA ZIMPRICH A., SIMON T., HOLLT V.; RT "Cloning and expression of an isoform of the rat mu opioid receptor RT (rMOR1B) which differs in agonist induced desensitization from RT rMOR1."; RL FEBS LETT. 359:142-146(1995). CC -!- FUNCTION: INHIBITS NEUROTRANSMITTER RELEASE BY REDUCING CALCIUM CC ION CURRENTS AND INCREASING POTASSIUM ION CONDUCTANCE. RECEPTOR CC FOR BETA-ENDORPHIN. CC -!- SUBCELLULAR LOCATION: INTEGRAL MEMBRANE PROTEIN. CC -!- TISSUE SPECIFICITY: BRAIN. IS EXPRESSED IN THE CEREBRAL CORTEX, CC CAUDATE PUTAMEN, NUCLEUS ACCUMBENS, SEPTAL NUCLEI, THALAMUS, CC HIPPOCAMPUS, AND HABENULA. NOT DETECTED IN CEREBELLUM. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; D16349; G391867; -. DR EMBL; L20684; G409150; -. DR EMBL; L13069; G348251; -. DR EMBL; U02083; G403574; -. DR EMBL; L22455; G437672; -. DR EMBL; U35424; G1017732; -. DR EMBL; S77863; E199500; -. DR EMBL; S75669; G861432; -. DR PIR; S34593; S34593. DR GCRDB; GCR_0633; -. DR GCRDB; GCR_0637; -. DR GCRDB; GCR_0639; -. DR GCRDB; GCR_0640; -. DR GCRDB; GCR_0864; -. DR GCRDB; GCR_1101; -. DR GCRDB; GCR_1425; -. DR GCRDB; GCR_2361; -. DR PROSITE; PS00237; G_PROTEIN_RECEPTOR; 1. DR PFAM; PF00001; 7tm_1; 1. KW G-PROTEIN COUPLED RECEPTOR; TRANSMEMBRANE; GLYCOPROTEIN; KW PHOSPHORYLATION; LIPOPROTEIN; PALMITATE. FT DOMAIN 1 64 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 65 94 1 (POTENTIAL). FT DOMAIN 95 103 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 104 121 2 (POTENTIAL). FT DOMAIN 122 143 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 144 163 3 (POTENTIAL). FT DOMAIN 164 193 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 194 209 4 (POTENTIAL). FT DOMAIN 210 234 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 235 257 5 (POTENTIAL). FT DOMAIN 258 280 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 281 303 6 (POTENTIAL). FT DOMAIN 304 311 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 312 328 7 (POTENTIAL). FT DOMAIN 329 398 CYTOPLASMIC (POTENTIAL). FT DISULFID 140 217 BY SIMILARITY. FT LIPID 351 351 PALMITATE (POTENTIAL). FT CARBOHYD 9 9 POTENTIAL. FT CARBOHYD 31 31 POTENTIAL. FT CARBOHYD 38 38 POTENTIAL. FT CARBOHYD 46 46 POTENTIAL. FT CARBOHYD 53 53 POTENTIAL. FT CONFLICT 237 237 F -> G (IN REF. 6). FT CONFLICT 245 245 V -> I (IN REF. 3, 4 AND 7). FT CONFLICT 387 391 LENLE -> KIVLF (IN REF. 8). SQ SEQUENCE 398 AA; 44494 MW; 2C21013D CRC32; MDSSTGPGNT SDCSDPLAQA SCSPAPGSWL NLSHVDGNQS DPCGLNRTGL GGNDSLCPQT GSPSMVTAIT IMALYSIVCV VGLFGNFLVM YVIVRYTKMK TATNIYIFNL ALADALATST LPFQSVNYLM GTWPFGTILC KIVISIDYYN MFTSIFTLCT MSVDRYIAVC HPVKALDFRT PRNAKIVNVC NWILSSAIGL PVMFMATTKY RQGSIDCTLT FSHPTWYWEN LLKICVFIFA FIMPVLIITV CYGLMILRLK SVRMLSGSKE KDRNLRRITR MVLVVVAVFI VCWTPIHIYV IIKALITIPE TTFQTVSWHF CIALGYTNSC LNPVLYAFLD ENFKRCFREF CIPTSSTIEQ QNSTRVRQNT REHPSTANTV DRTNHQLENL EAETAPLP //