ID OPRM_RAT STANDARD; PRT; 398 AA. AC P33535; Q64064; Q62846; Q64120; DT 01-FEB-1994 (REL. 28, CREATED) DT 01-FEB-1994 (REL. 28, LAST SEQUENCE UPDATE) DT 15-JUL-1998 (REL. 36, LAST ANNOTATION UPDATE) DE MU-TYPE OPIOID RECEPTOR (MOR-1) (OPIOID RECEPTOR B) (MUOR1). GN OPRM1 OR ROR-B. OS RATTUS NORVEGICUS (RAT). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; RODENTIA. RN [1] RP SEQUENCE FROM N.A. RC TISSUE=BRAIN; RX MEDLINE; 93351652. RA FUKUDA K., KATO S., MORI K., NISHI M., TAKESHIMA H.; RL FEBS LETT. 327:311-314(1993). RN [2] RP SEQUENCE FROM N.A. RC TISSUE=BRAIN; RX MEDLINE; 94052137. RA WANG J.-B., IMAI Y., EPLER M.C., GREGOR P., SPIVAK C., UHL G.R.; RL PROC. NATL. ACAD. SCI. U.S.A. 90:10230-10234(1993). RN [3] RP SEQUENCE FROM N.A. RC TISSUE=BRAIN; RX MEDLINE; 93341493. RA CHEN Y., MESTEK A., LIU J., HURLEY J.A., YU L.; RL MOL. PHARMACOL. 44:8-12(1993). RN [4] RP SEQUENCE FROM N.A. RC STRAIN=SPRAGUE-DAWLEY; TISSUE=BRAIN; RA BUNZOW J.R., GRANDY D.K., KELLY M.; RL SUBMITTED (SEP-1993) TO EMBL/GENBANK/DDBJ DATA BANKS. RN [5] RP SEQUENCE FROM N.A. RC STRAIN=SPRAGUE-DAWLEY; TISSUE=OLFACTORY BULB; RX MEDLINE; 94059560. RA THOMPSON R.C., MANSOUR A., AKIL H., WATSON S.J.; RL NEURON 11:903-913(1993). RN [6] RP SEQUENCE FROM N.A. RC TISSUE=BRAIN; RX MEDLINE; 94246380. RA ZASTAWNY R.L., GEORGE S.R., NGUYEN T., CHENG R., TSATSOS J., RA BRIONES-URBINA R., O'DOWD B.F.; RL J. NEUROCHEM. 62:2099-2105(1994). RN [7] RP SEQUENCE OF 101-340 FROM N.A. RC TISSUE=MACROPHAGE; RX MEDLINE; 95251654. RA SEDQI M., ROY S., RAMAKRISHNAN S., ELDE R., LOH H.H.; RL BIOCHEM. BIOPHYS. RES. COMMUN. 209:563-574(1995). RN [8] RP SEQUENCE OF 356-391 FROM N.A. RX MEDLINE; 95172221. RA ZIMPRICH A., SIMON T., HOLLT V.; RL FEBS LETT. 359:142-146(1995). CC -!- FUNCTION: INHIBITS NEUROTRANSMITTER RELEASE BY REDUCING CALCIUM CC ION CURRENTS AND INCREASING POTASSIUM ION CONDUCTANCE. RECEPTOR CC FOR BETA-ENDORPHIN. CC -!- SUBCELLULAR LOCATION: INTEGRAL MEMBRANE PROTEIN. CC -!- TISSUE SPECIFICITY: BRAIN. IS EXPRESSED IN THE CEREBRAL CORTEX, CC CAUDATE PUTAMEN, NUCLEUS ACCUMBENS, SEPTAL NUCLEI, THALAMUS, CC HIPPOCAMPUS, AND HABENULA. NOT DETECTED IN CEREBELLUM. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; D16349; G391867; -. DR EMBL; L20684; G409150; -. DR EMBL; L13069; G348251; -. DR EMBL; U02083; G403574; -. DR EMBL; L22455; G437672; -. DR EMBL; U35424; G1017732; -. DR EMBL; S77863; E199500; -. DR EMBL; S75669; G861432; -. DR PIR; S34593; S34593. DR GCRDB; GCR_0633; -. DR GCRDB; GCR_0637; -. DR GCRDB; GCR_0639; -. DR GCRDB; GCR_0640; -. DR GCRDB; GCR_0864; -. DR GCRDB; GCR_1101; -. DR GCRDB; GCR_1425; -. DR GCRDB; GCR_2361; -. DR PROSITE; PS00237; G_PROTEIN_RECEPTOR; 1. KW G-PROTEIN COUPLED RECEPTOR; TRANSMEMBRANE; GLYCOPROTEIN; KW PHOSPHORYLATION; LIPOPROTEIN; PALMITATE. FT DOMAIN 1 64 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 65 94 1 (POTENTIAL). FT DOMAIN 95 103 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 104 121 2 (POTENTIAL). FT DOMAIN 122 143 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 144 163 3 (POTENTIAL). FT DOMAIN 164 193 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 194 209 4 (POTENTIAL). FT DOMAIN 210 234 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 235 257 5 (POTENTIAL). FT DOMAIN 258 280 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 281 303 6 (POTENTIAL). FT DOMAIN 304 311 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 312 328 7 (POTENTIAL). FT DOMAIN 329 398 CYTOPLASMIC (POTENTIAL). FT DISULFID 140 217 BY SIMILARITY. FT LIPID 351 351 PALMITATE (POTENTIAL). FT CARBOHYD 9 9 POTENTIAL. FT CARBOHYD 31 31 POTENTIAL. FT CARBOHYD 38 38 POTENTIAL. FT CARBOHYD 46 46 POTENTIAL. FT CARBOHYD 53 53 POTENTIAL. FT CONFLICT 237 237 F -> G (IN REF. 6). FT CONFLICT 245 245 V -> I (IN REF. 3, 4 AND 7). FT CONFLICT 387 391 LENLE -> KIVLF (IN REF. 8). SQ SEQUENCE 398 AA; 44494 MW; 2C21013D CRC32; MDSSTGPGNT SDCSDPLAQA SCSPAPGSWL NLSHVDGNQS DPCGLNRTGL GGNDSLCPQT GSPSMVTAIT IMALYSIVCV VGLFGNFLVM YVIVRYTKMK TATNIYIFNL ALADALATST LPFQSVNYLM GTWPFGTILC KIVISIDYYN MFTSIFTLCT MSVDRYIAVC HPVKALDFRT PRNAKIVNVC NWILSSAIGL PVMFMATTKY RQGSIDCTLT FSHPTWYWEN LLKICVFIFA FIMPVLIITV CYGLMILRLK SVRMLSGSKE KDRNLRRITR MVLVVVAVFI VCWTPIHIYV IIKALITIPE TTFQTVSWHF CIALGYTNSC LNPVLYAFLD ENFKRCFREF CIPTSSTIEQ QNSTRVRQNT REHPSTANTV DRTNHQLENL EAETAPLP //