ID OPRM_RAT STANDARD; PRT; 398 AA. AC P33535; DT 01-FEB-1994 (REL. 28, CREATED) DT 01-FEB-1994 (REL. 28, LAST SEQUENCE UPDATE) DT 01-JUN-1994 (REL. 29, LAST ANNOTATION UPDATE) DE MU-TYPE OPIOID RECEPTOR (MOR-1) (OPIOID RECEPTOR B) (MUOR1). GN ROR-B. OS RATTUS NORVEGICUS (RAT). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; RODENTIA. RN [1] RP SEQUENCE FROM N.A. RC TISSUE=BRAIN; RM 93351652 RA FUKUDA K., KATO S., MORI K., NISHI M., TAKESHIMA H.; RL FEBS LETT. 327:311-314(1993). RN [2] RP SEQUENCE FROM N.A. RC TISSUE=BRAIN; RM 94052137 RA WANG J.-B., IMAI Y., EPLER M.C., GREGOR P., SPIVAK C., UHL G.R.; RL PROC. NATL. ACAD. SCI. U.S.A. 90:10230-10234(1993). RN [3] RP SEQUENCE FROM N.A. RC TISSUE=BRAIN; RM 93341493 RA CHEN Y., MESTEK A., LIU J., HURLEY J.A., YU L.; RL MOL. PHARMACOL. 44:8-12(1993). RN [4] RP SEQUENCE FROM N.A. RC STRAIN=SPRAGUE-DAWLEY; TISSUE=BRAIN; RA BUNZOW J.R., GRANDY D.K., KELLY M.; RL SUBMITTED (SEP-1993) TO EMBL/GENBANK/DDBJ DATA BANKS. RN [5] RP SEQUENCE FROM N.A. RC STRAIN=SPRAGUE-DAWLEY; TISSUE=OLFACTORY BULB; RM 94059560 RA THOMPSON R.C., MANSOUR A., AKIL H., WATSON S.J.; RL NEURON 11:903-913(1993). CC -!- FUNCTION: INHIBITS NEUROTRANSMITTER RELEASE BY REDUCING CALCIUM CC ION CURRENTS AND INCREASING POTASSIUM ION CONDUCTANCE. RECEPTOR CC FOR BETA-ENDORPHIN. CC -!- SUBCELLULAR LOCATION: INTEGRAL MEMBRANE PROTEIN. CC -!- TISSUE SPECIFICITY: BRAIN, WITH HIGH CONCENTRATIONS IN THE CC BRAINSTEM AND CEREBRUM. NOT DETECTED IN CEREBELLUM. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; D16349; RNRORB. DR EMBL; L20684; RNMUOR1A. DR EMBL; L13069; RNMORA. DR EMBL; U02083; RNU02083. DR EMBL; L22455; RNMOPIOID. DR PIR; S34593; S34593. DR GCRDB; GCR_0633; -. DR GCRDB; GCR_0637; -. DR GCRDB; GCR_0639; -. DR GCRDB; GCR_0640; -. DR GCRDB; GCR_0864; -. DR PROSITE; PS00237; G_PROTEIN_RECEPTOR. KW G-PROTEIN COUPLED RECEPTOR; TRANSMEMBRANE; GLYCOPROTEIN; KW PHOSPHORYLATION; LIPOPROTEIN; PALMITATE. FT DOMAIN 1 64 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 65 94 1 (POTENTIAL). FT DOMAIN 95 103 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 104 121 2 (POTENTIAL). FT DOMAIN 122 143 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 144 163 3 (POTENTIAL). FT DOMAIN 164 193 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 194 209 4 (POTENTIAL). FT DOMAIN 210 234 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 235 257 5 (POTENTIAL). FT DOMAIN 258 280 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 281 303 6 (POTENTIAL). FT DOMAIN 304 311 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 312 328 7 (POTENTIAL). FT DOMAIN 329 398 CYTOPLASMIC (POTENTIAL). FT DISULFID 140 217 BY SIMILARITY. FT LIPID 351 351 PALMITATE (POTENTIAL). FT CARBOHYD 9 9 POTENTIAL. FT CARBOHYD 31 31 POTENTIAL. FT CARBOHYD 38 38 POTENTIAL. FT CARBOHYD 46 46 POTENTIAL. FT CARBOHYD 53 53 POTENTIAL. FT CONFLICT 245 245 V -> I (IN REF. 3 AND 4). SQ SEQUENCE 398 AA; 44494 MW; 873231 CN; MDSSTGPGNT SDCSDPLAQA SCSPAPGSWL NLSHVDGNQS DPCGLNRTGL GGNDSLCPQT GSPSMVTAIT IMALYSIVCV VGLFGNFLVM YVIVRYTKMK TATNIYIFNL ALADALATST LPFQSVNYLM GTWPFGTILC KIVISIDYYN MFTSIFTLCT MSVDRYIAVC HPVKALDFRT PRNAKIVNVC NWILSSAIGL PVMFMATTKY RQGSIDCTLT FSHPTWYWEN LLKICVFIFA FIMPVLIITV CYGLMILRLK SVRMLSGSKE KDRNLRRITR MVLVVVAVFI VCWTPIHIYV IIKALITIPE TTFQTVSWHF CIALGYTNSC LNPVLYAFLD ENFKRCFREF CIPTSSTIEQ QNSTRVRQNT REHPSTANTV DRTNHQLENL EAETAPLP //