ID OPRM_RAT STANDARD; PRT; 398 AA. AC P33535; Q62846; Q64064; Q64120; DT 01-FEB-1994 (Rel. 28, Created) DT 01-FEB-1994 (Rel. 28, Last sequence update) DT 16-OCT-2001 (Rel. 40, Last annotation update) DE Mu-type opioid receptor (MOR-1) (Opioid receptor B) (MUOR1). GN OPRM1 OR ROR-B. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Brain; RX MEDLINE=93351652; PubMed=8394245; RA Fukuda K., Kato S., Mori K., Nishi M., Takeshima H.; RT "Primary structures and expression from cDNAs of rat opioid receptor RT delta- and mu-subtypes."; RL FEBS Lett. 327:311-314(1993). RN [2] RP SEQUENCE FROM N.A. RC TISSUE=Brain; RX MEDLINE=94052137; PubMed=8234282; RA Wang J.-B., Imai Y., Epler M.C., Gregor P., Spivak C., Uhl G.R.; RT "Mu opiate receptor: cDNA cloning and expression."; RL Proc. Natl. Acad. Sci. U.S.A. 90:10230-10234(1993). RN [3] RP SEQUENCE FROM N.A. RC TISSUE=Brain; RX MEDLINE=93341493; PubMed=8393525; RA Chen Y., Mestek A., Liu J., Hurley J.A., Yu L.; RT "Molecular cloning and functional expression of a mu-opioid receptor RT from rat brain."; RL Mol. Pharmacol. 44:8-12(1993). RN [4] RP SEQUENCE FROM N.A. RC STRAIN=Sprague-Dawley; TISSUE=Brain; RA Bunzow J.R., Grandy D.K., Kelly M.; RL Submitted (SEP-1993) to the EMBL/GenBank/DDBJ databases. RN [5] RP SEQUENCE FROM N.A. RC STRAIN=Sprague-Dawley; TISSUE=Olfactory bulb; RX MEDLINE=94059560; PubMed=8240812; RA Thompson R.C., Mansour A., Akil H., Watson S.J.; RT "Cloning and pharmacological characterization of a rat mu opioid RT receptor."; RL Neuron 11:903-913(1993). RN [6] RP SEQUENCE FROM N.A. RC TISSUE=Brain; RX MEDLINE=94246380; PubMed=8189219; RA Zastawny R.L., George S.R., Nguyen T., Cheng R., Tsatsos J., RA Briones-Urbina R., O'Dowd B.F.; RT "Cloning, characterization, and distribution of a mu-opioid receptor RT in rat brain."; RL J. Neurochem. 62:2099-2105(1994). RN [7] RP SEQUENCE OF 101-340 FROM N.A. RC TISSUE=Macrophage; RX MEDLINE=95251654; PubMed=7733926; RA Sedqi M., Roy S., Ramakrishnan S., Elde R., Loh H.H.; RT "Complementary DNA cloning of a mu-opioid receptor from rat RT peritoneal macrophages."; RL Biochem. Biophys. Res. Commun. 209:563-574(1995). RN [8] RP SEQUENCE OF 356-391 FROM N.A. RX MEDLINE=95172221; PubMed=7532594; RA Zimprich A., Simon T., Hoellt V.; RT "Cloning and expression of an isoform of the rat mu opioid receptor RT (rMOR1B) which differs in agonist induced desensitization from RT rMOR1."; RL FEBS Lett. 359:142-146(1995). CC -!- FUNCTION: INHIBITS NEUROTRANSMITTER RELEASE BY REDUCING CALCIUM CC ION CURRENTS AND INCREASING POTASSIUM ION CONDUCTANCE. RECEPTOR CC FOR BETA-ENDORPHIN. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. CC -!- TISSUE SPECIFICITY: BRAIN. IS EXPRESSED IN THE CEREBRAL CORTEX, CC CAUDATE PUTAMEN, NUCLEUS ACCUMBENS, SEPTAL NUCLEI, THALAMUS, CC HIPPOCAMPUS, AND HABENULA. NOT DETECTED IN CEREBELLUM. CC -!- SIMILARITY: Belongs to family 1 of G-protein coupled receptors. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; D16349; BAA03852.1; -. DR EMBL; L20684; AAA41643.1; -. DR EMBL; L13069; AAA41630.1; -. DR EMBL; U02083; AAA70049.1; -. DR EMBL; L22455; AAA16075.1; -. DR EMBL; U35424; AAA79180.1; -. DR EMBL; S77863; -; NOT_ANNOTATED_CDS. DR EMBL; S75669; AAB33530.2; -. DR PIR; I56504; I56504. DR PIR; I56517; I56517. DR PIR; S69010; S69010. DR InterPro; IPR000276; GPCR_Rhodpsn. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; KW Phosphorylation; Lipoprotein; Palmitate. FT DOMAIN 1 64 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 65 94 1 (POTENTIAL). FT DOMAIN 95 103 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 104 121 2 (POTENTIAL). FT DOMAIN 122 143 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 144 163 3 (POTENTIAL). FT DOMAIN 164 193 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 194 209 4 (POTENTIAL). FT DOMAIN 210 234 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 235 257 5 (POTENTIAL). FT DOMAIN 258 280 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 281 303 6 (POTENTIAL). FT DOMAIN 304 311 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 312 328 7 (POTENTIAL). FT DOMAIN 329 398 CYTOPLASMIC (POTENTIAL). FT DISULFID 140 217 BY SIMILARITY. FT LIPID 351 351 PALMITATE (POTENTIAL). FT CARBOHYD 9 9 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 31 31 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 38 38 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 46 46 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 53 53 N-LINKED (GLCNAC...) (POTENTIAL). FT CONFLICT 237 237 F -> G (IN REF. 6). FT CONFLICT 245 245 V -> I (IN REF. 3, 4 AND 7). FT CONFLICT 387 391 LENLE -> KIVLF (IN REF. 8). SQ SEQUENCE 398 AA; 44494 MW; 9C916DE7C1C33743 CRC64; MDSSTGPGNT SDCSDPLAQA SCSPAPGSWL NLSHVDGNQS DPCGLNRTGL GGNDSLCPQT GSPSMVTAIT IMALYSIVCV VGLFGNFLVM YVIVRYTKMK TATNIYIFNL ALADALATST LPFQSVNYLM GTWPFGTILC KIVISIDYYN MFTSIFTLCT MSVDRYIAVC HPVKALDFRT PRNAKIVNVC NWILSSAIGL PVMFMATTKY RQGSIDCTLT FSHPTWYWEN LLKICVFIFA FIMPVLIITV CYGLMILRLK SVRMLSGSKE KDRNLRRITR MVLVVVAVFI VCWTPIHIYV IIKALITIPE TTFQTVSWHF CIALGYTNSC LNPVLYAFLD ENFKRCFREF CIPTSSTIEQ QNSTRVRQNT REHPSTANTV DRTNHQLENL EAETAPLP //