ID CASA2_CAPHI Reviewed; 223 AA. AC P33049; Q9GK07; Q9MYU6; Q9MYU7; Q9TTQ7; DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1993, sequence version 1. DT 27-MAR-2024, entry version 94. DE RecName: Full=Alpha-S2-casein; DE Short=Alpha-S2-CN; DE Flags: Precursor; GN Name=CSN1S2; OS Capra hircus (Goat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; OC Caprinae; Capra. OX NCBI_TaxID=9925; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=8462880; DOI=10.1016/0378-1119(93)90336-2; RA Bouniol C.; RT "Sequence of the goat alpha s2-casein-encoding cDNA."; RL Gene 125:235-236(1993). RN [2] RP NUCLEOTIDE SEQUENCE, AND VARIANT ALLELE B LYS-79. RA Bouniol C., Brignon G., Mahe M.-F., Printz C.; RT "Characterization of goat allelic alpha-s2-caseins A and B: further RT evidence of the phosphorylation code of caseins."; RL Protein Seq. Data Anal. 5:213-218(1993). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT ALLELE C ILE-182. RX PubMed=7943951; DOI=10.1111/j.1365-2052.1994.tb00106.x; RA Bouniol C., Brignon G., Mahe M.-F., Printz C.; RT "Biochemical and genetic analysis of variant C of caprine alpha s2-casein RT (Capra hircus)."; RL Anim. Genet. 25:173-177(1994). RN [4] RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT ALLELE F ILE-22. RX PubMed=11683712; DOI=10.1046/j.1365-2052.2001.00786.x; RA Ramunno L., Cosenza G., Pappalardo M., Longobardi E., Gallo D., Pastore N., RA Di Gregorio P., Rando A.; RT "Characterization of two new alleles at the goat CSN1S2 locus."; RL Anim. Genet. 32:264-268(2001). RN [5] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND VARIANTS ILE-182 AND ARG-208. RX PubMed=11736814; DOI=10.1046/j.1365-2052.2001.0781c.x; RA Lagonigro R., Pietrola E., D'Andrea M., Veltri C., Pilla F.; RT "Molecular genetic characterization of the goat s2-casein E allele."; RL Anim. Genet. 32:391-393(2001). CC -!- FUNCTION: Important role in the capacity of milk to transport calcium CC phosphate. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Mammary gland specific. Secreted in milk. CC -!- POLYMORPHISM: The frequencies of the A, B and C alleles is estimated to CC be 0.85, 0.04 and 0.11 in the French dairy breeds 'Alpine' and CC 'Saanen'. CC -!- SIMILARITY: Belongs to the alpha-casein family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X65160; CAA46278.1; -; mRNA. DR EMBL; S74171; AAB32166.1; -; Genomic_DNA. DR EMBL; AJ249995; CAB59920.1; -; mRNA. DR EMBL; AJ289715; CAB94235.1; -; mRNA. DR EMBL; AJ289716; CAB94236.1; -; mRNA. DR EMBL; AJ297310; CAC21704.2; -; Genomic_DNA. DR EMBL; AJ242526; CAC21704.2; JOINED; Genomic_DNA. DR EMBL; AJ242528; CAC21704.2; JOINED; Genomic_DNA. DR EMBL; AJ242527; CAC21704.2; JOINED; Genomic_DNA. DR EMBL; AJ242533; CAC21704.2; JOINED; Genomic_DNA. DR EMBL; AJ297311; CAC21704.2; JOINED; Genomic_DNA. DR EMBL; AJ297313; CAC21704.2; JOINED; Genomic_DNA. DR EMBL; AJ297315; CAC21704.2; JOINED; Genomic_DNA. DR EMBL; AJ297316; CAC21704.2; JOINED; Genomic_DNA. DR EMBL; AJ297314; CAC21704.2; JOINED; Genomic_DNA. DR EMBL; AJ297312; CAC21704.2; JOINED; Genomic_DNA. DR EMBL; AJ242728; CAC21704.2; JOINED; Genomic_DNA. DR PIR; I46995; I46995. DR PIR; S33881; JN0547. DR RefSeq; NP_001272514.1; NM_001285585.1. DR AlphaFoldDB; P33049; -. DR SMR; P33049; -. DR Allergome; 1242; Cap h 8. DR Allergome; 2967; Cap h 10. DR GeneID; 100861229; -. DR KEGG; chx:100861229; -. DR CTD; 282209; -. DR OrthoDB; 5223369at2759; -. DR Proteomes; UP000291000; Unassembled WGS sequence. DR Proteomes; UP000694566; Unplaced. DR Proteomes; UP000694900; Genome assembly. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR InterPro; IPR011175; Alpha-s2_casein. DR InterPro; IPR001588; Casein. DR InterPro; IPR031305; Casein_CS. DR PANTHER; PTHR16656; ALPHA-S2-CASEIN-LIKE B; 1. DR PANTHER; PTHR16656:SF5; ALPHA-S2-CASEIN-LIKE B; 1. DR Pfam; PF00363; Casein; 1. DR PIRSF; PIRSF002371; Alpha-s2-casein; 1. DR PROSITE; PS00306; CASEIN_ALPHA_BETA; 1. PE 2: Evidence at transcript level; KW Milk protein; Phosphoprotein; Reference proteome; Repeat; Secreted; Signal. FT SIGNAL 1..15 FT /evidence="ECO:0000250" FT CHAIN 16..223 FT /note="Alpha-S2-casein" FT /id="PRO_0000004463" FT REPEAT 77..141 FT REPEAT 159..223 FT MOD_RES 23 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:P02663" FT MOD_RES 24 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:P02663" FT MOD_RES 25 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:P02663" FT MOD_RES 72 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:P02663" FT MOD_RES 73 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:P02663" FT MOD_RES 74 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:P02663" FT MOD_RES 77 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:P02663" FT MOD_RES 145 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:O97944" FT MOD_RES 147 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:O97944" FT MOD_RES 151 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:O97944" FT MOD_RES 159 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:P02663" FT VARIANT 22 FT /note="V -> I (in allele F)" FT /evidence="ECO:0000269|PubMed:11683712" FT VARIANT 79 FT /note="E -> K (in allele B)" FT /evidence="ECO:0000269|Ref.2" FT VARIANT 161 FT /note="E -> K (in allele 0)" FT VARIANT 182 FT /note="K -> I (in allele C and allele E)" FT /evidence="ECO:0000269|PubMed:11736814, FT ECO:0000269|PubMed:7943951" FT VARIANT 208 FT /note="P -> R (in allele E)" FT /evidence="ECO:0000269|PubMed:11736814" SQ SEQUENCE 223 AA; 26389 MW; 187DEF42FD688291 CRC64; MKFFIFTCLL AVALAKHKME HVSSSEEPIN IFQEIYKQEK NMAIHPRKEK LCTTSCEEVV RNANEEEYSI RSSSEESAEV APEEIKITVD DKHYQKALNE INQFYQKFPQ YLQYPYQGPI VLNPWDQVKR NAGPFTPTVN REQLSTSEEN SKKTIDMEST EVFTKKTKLT EEEKNRLNFL KKISQYYQKF AWPQYLKTVD QHQKAMKPWT QPKTNAIPYV RYL //