ID CAS2_CAPHI STANDARD; PRT; 223 AA. AC P33049; DT 01-OCT-1993 (Rel. 27, Created) DT 01-OCT-1993 (Rel. 27, Last sequence update) DT 01-NOV-1997 (Rel. 35, Last annotation update) DE ALPHA-S2 CASEIN PRECURSOR (ALPHA-S2-CN). GN CSN1S2. OS Capra hircus (Goat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia; OC Eutheria; Cetartiodactyla; Ruminantia; Pecora; Bovoidea; Bovidae; OC Caprinae; Capra. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 93216130. RA BOUNIOL C.; RT "Sequence of the goat alpha s2-casein-encoding cDNA."; RL Gene 125:235-236(1993). RN [2] RP SEQUENCE FROM N.A. RA BOUNIOL C., BRIGNON G., MAHE M.F., PRINTZ C.; RT "Characterization of goat allelic alpha-s2-caseins A and B: further RT evidence of the phosphorylation code of caseins."; RL Protein Seq. Data Anal. 5:213-218(1993). RN [3] RP SEQUENCE FROM N.A. (VARIANT C). RX MEDLINE; 95030556. RA BOUNIOL C., BRIGNON G., MAHE M.F., PRINTZ C.; RT "Biochemical and genetic analysis of variant C of caprine alpha s2- RT casein (Capra hircus)."; RL Anim. Genet. 25:173-177(1994). CC -!- FUNCTION: IMPORTANT ROLE IN THE CAPACITY OF MILK TO TRANSPORT CC CALCIUM PHOSPHATE. CC -!- SUBCELLULAR LOCATION: EXTRACELLULAR. CC -!- TISSUE SPECIFICITY: MAMMARY GLAND; MILK. CC -!- POLYMORPHISM: THREE ALLELES OF ALPHA-S2 CASEIN ARE KNOWN: A, B AND CC C. THE FREQUENCIES OF THE ALLELES IS ESTIMATED TO BE 0.85, 0.04 CC AND 0.11 IN THE FRENCH DAIRY BREEDS 'ALPINE' AND 'SAANEN'. CC -!- SIMILARITY: BELONGS TO THE ALPHA-CASEIN FAMILY. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X65160; CAA46278.1; -. DR EMBL; S74171; AAB32166.1; -. DR PIR; S20620; S20620. DR PIR; JN0547; JN0547. DR PIR; S33880; S33880. DR PIR; S33881; S33881. DR PFAM; PF00363; caseins; 2. DR PROSITE; PS00306; CASEIN_ALPHA_BETA; 1. KW Milk; Phosphorylation; Duplication; Signal; Polymorphism. FT SIGNAL 1 15 BY SIMILARITY. FT CHAIN 16 223 ALPHA-S2 CASEIN. FT REPEAT 77 141 FT REPEAT 159 223 FT MOD_RES 23 23 PHOSPHORYLATION (BY SIMILARITY). FT MOD_RES 24 24 PHOSPHORYLATION (BY SIMILARITY). FT MOD_RES 25 25 PHOSPHORYLATION (BY SIMILARITY). FT MOD_RES 72 72 PHOSPHORYLATION (BY SIMILARITY). FT MOD_RES 73 73 PHOSPHORYLATION (BY SIMILARITY). FT MOD_RES 74 74 PHOSPHORYLATION (BY SIMILARITY). FT MOD_RES 77 77 PHOSPHORYLATION (BY SIMILARITY). FT MOD_RES 145 145 PHOSPHORYLATION (BY SIMILARITY). FT MOD_RES 147 147 PHOSPHORYLATION (BY SIMILARITY). FT VARIANT 79 79 E -> K (IN VARIANT B). FT VARIANT 182 182 K -> I (IN VARIANT C). SQ SEQUENCE 223 AA; 26389 MW; 1F460B61 CRC32; MKFFIFTCLL AVALAKHKME HVSSSEEPIN IFQEIYKQEK NMAIHPRKEK LCTTSCEEVV RNANEEEYSI RSSSEESAEV APEEIKITVD DKHYQKALNE INQFYQKFPQ YLQYPYQGPI VLNPWDQVKR NAGPFTPTVN REQLSTSEEN SKKTIDMEST EVFTKKTKLT EEEKNRLNFL KKISQYYQKF AWPQYLKTVD QHQKAMKPWT QPKTNAIPYV RYL //