ID CASA2_CAPHI Reviewed; 223 AA. AC P33049; Q9GK07; Q9MYU6; Q9MYU7; Q9TTQ7; DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1993, sequence version 1. DT 15-MAR-2017, entry version 78. DE RecName: Full=Alpha-S2-casein; DE Short=Alpha-S2-CN; DE Flags: Precursor; GN Name=CSN1S2; OS Capra hircus (Goat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Caprinae; Capra. OX NCBI_TaxID=9925; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=8462880; DOI=10.1016/0378-1119(93)90336-2; RA Bouniol C.; RT "Sequence of the goat alpha s2-casein-encoding cDNA."; RL Gene 125:235-236(1993). RN [2] RP NUCLEOTIDE SEQUENCE, AND VARIANT ALLELE B LYS-79. RA Bouniol C., Brignon G., Mahe M.-F., Printz C.; RT "Characterization of goat allelic alpha-s2-caseins A and B: further RT evidence of the phosphorylation code of caseins."; RL Protein Seq. Data Anal. 5:213-218(1993). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT ALLELE C ILE-182. RX PubMed=7943951; RA Bouniol C., Brignon G., Mahe M.-F., Printz C.; RT "Biochemical and genetic analysis of variant C of caprine alpha s2- RT casein (Capra hircus)."; RL Anim. Genet. 25:173-177(1994). RN [4] RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT ALLELE F ILE-22. RX PubMed=11683712; DOI=10.1046/j.1365-2052.2001.00786.x; RA Ramunno L., Cosenza G., Pappalardo M., Longobardi E., Gallo D., RA Pastore N., Di Gregorio P., Rando A.; RT "Characterization of two new alleles at the goat CSN1S2 locus."; RL Anim. Genet. 32:264-268(2001). RN [5] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND VARIANTS ILE-182 AND RP ARG-208. RX PubMed=11736814; DOI=10.1046/j.1365-2052.2001.0781c.x; RA Lagonigro R., Pietrola E., D'Andrea M., Veltri C., Pilla F.; RT "Molecular genetic characterization of the goat s2-casein E allele."; RL Anim. Genet. 32:391-393(2001). CC -!- FUNCTION: Important role in the capacity of milk to transport CC calcium phosphate. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Mammary gland specific. Secreted in milk. CC -!- POLYMORPHISM: The frequencies of the A, B and C alleles is CC estimated to be 0.85, 0.04 and 0.11 in the French dairy breeds CC 'Alpine' and 'Saanen'. CC -!- SIMILARITY: Belongs to the alpha-casein family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X65160; CAA46278.1; -; mRNA. DR EMBL; S74171; AAB32166.1; -; Genomic_DNA. DR EMBL; AJ249995; CAB59920.1; -; mRNA. DR EMBL; AJ289715; CAB94235.1; -; mRNA. DR EMBL; AJ289716; CAB94236.1; -; mRNA. DR EMBL; AJ297310; CAC21704.2; -; Genomic_DNA. DR EMBL; AJ242526; CAC21704.2; JOINED; Genomic_DNA. DR EMBL; AJ242528; CAC21704.2; JOINED; Genomic_DNA. DR EMBL; AJ242527; CAC21704.2; JOINED; Genomic_DNA. DR EMBL; AJ242533; CAC21704.2; JOINED; Genomic_DNA. DR EMBL; AJ297311; CAC21704.2; JOINED; Genomic_DNA. DR EMBL; AJ297313; CAC21704.2; JOINED; Genomic_DNA. DR EMBL; AJ297315; CAC21704.2; JOINED; Genomic_DNA. DR EMBL; AJ297316; CAC21704.2; JOINED; Genomic_DNA. DR EMBL; AJ297314; CAC21704.2; JOINED; Genomic_DNA. DR EMBL; AJ297312; CAC21704.2; JOINED; Genomic_DNA. DR EMBL; AJ242728; CAC21704.2; JOINED; Genomic_DNA. DR PIR; I46995; I46995. DR PIR; S33881; JN0547. DR RefSeq; NP_001272514.1; NM_001285585.1. DR UniGene; Chi.518; -. DR Allergome; 1242; Cap h 8. DR Allergome; 2967; Cap h 10. DR GeneID; 100861229; -. DR KEGG; chx:100861229; -. DR CTD; 100327035; -. DR HOVERGEN; HBG005244; -. DR OrthoDB; EOG091G0QMQ; -. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0005215; F:transporter activity; IEA:InterPro. DR InterPro; IPR011175; Alpha-s2_casein. DR InterPro; IPR001588; Casein. DR InterPro; IPR031305; Casein_CS. DR Pfam; PF00363; Casein; 2. DR PIRSF; PIRSF002371; Alpha-s2-casein; 1. DR PROSITE; PS00306; CASEIN_ALPHA_BETA; 1. PE 2: Evidence at transcript level; KW Milk protein; Phosphoprotein; Polymorphism; Repeat; Secreted; Signal. FT SIGNAL 1 15 {ECO:0000250}. FT CHAIN 16 223 Alpha-S2-casein. FT /FTId=PRO_0000004463. FT REPEAT 77 141 FT REPEAT 159 223 FT MOD_RES 23 23 Phosphoserine. FT {ECO:0000250|UniProtKB:P02663}. FT MOD_RES 24 24 Phosphoserine. FT {ECO:0000250|UniProtKB:P02663}. FT MOD_RES 25 25 Phosphoserine. FT {ECO:0000250|UniProtKB:P02663}. FT MOD_RES 72 72 Phosphoserine. FT {ECO:0000250|UniProtKB:P02663}. FT MOD_RES 73 73 Phosphoserine. FT {ECO:0000250|UniProtKB:P02663}. FT MOD_RES 74 74 Phosphoserine. FT {ECO:0000250|UniProtKB:P02663}. FT MOD_RES 77 77 Phosphoserine. FT {ECO:0000250|UniProtKB:P02663}. FT MOD_RES 159 159 Phosphoserine. FT {ECO:0000250|UniProtKB:P02663}. FT VARIANT 22 22 V -> I (in allele F). FT {ECO:0000269|PubMed:11683712}. FT VARIANT 79 79 E -> K (in allele B). FT {ECO:0000269|Ref.2}. FT VARIANT 161 161 E -> K (in allele 0). FT VARIANT 182 182 K -> I (in allele C and allele E). FT {ECO:0000269|PubMed:11736814, FT ECO:0000269|PubMed:7943951}. FT VARIANT 208 208 P -> R (in allele E). FT {ECO:0000269|PubMed:11736814}. SQ SEQUENCE 223 AA; 26389 MW; 187DEF42FD688291 CRC64; MKFFIFTCLL AVALAKHKME HVSSSEEPIN IFQEIYKQEK NMAIHPRKEK LCTTSCEEVV RNANEEEYSI RSSSEESAEV APEEIKITVD DKHYQKALNE INQFYQKFPQ YLQYPYQGPI VLNPWDQVKR NAGPFTPTVN REQLSTSEEN SKKTIDMEST EVFTKKTKLT EEEKNRLNFL KKISQYYQKF AWPQYLKTVD QHQKAMKPWT QPKTNAIPYV RYL //