ID CAS2_CAPHI STANDARD; PRT; 223 AA. AC P33049; DT 01-OCT-1993 (Rel. 27, Created) DT 01-OCT-1993 (Rel. 27, Last sequence update) DT 15-SEP-2003 (Rel. 42, Last annotation update) DE Alpha-S2 casein precursor (Alpha-S2-CN). GN CSN1S2. OS Capra hircus (Goat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Cetartiodactyla; Ruminantia; Pecora; Bovoidea; OC Bovidae; Caprinae; Capra. OX NCBI_TaxID=9925; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=93216130; PubMed=8462880; RA Bouniol C.; RT "Sequence of the goat alpha s2-casein-encoding cDNA."; RL Gene 125:235-236(1993). RN [2] RP SEQUENCE FROM N.A. RA Bouniol C., Brignon G., Mahe M.-F., Printz C.; RT "Characterization of goat allelic alpha-s2-caseins A and B: further RT evidence of the phosphorylation code of caseins."; RL Protein Seq. Data Anal. 5:213-218(1993). RN [3] RP SEQUENCE FROM N.A. (VARIANT C). RX MEDLINE=95030556; PubMed=7943951; RA Bouniol C., Brignon G., Mahe M.F., Printz C.; RT "Biochemical and genetic analysis of variant C of caprine alpha s2- RT casein (Capra hircus)."; RL Anim. Genet. 25:173-177(1994). CC -!- FUNCTION: Important role in the capacity of milk to transport CC calcium phosphate. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Mammary gland specific. Secreted in milk. CC -!- POLYMORPHISM: THREE ALLELES OF ALPHA-S2 CASEIN ARE KNOWN: A, B AND CC C. THE FREQUENCIES OF THE ALLELES IS ESTIMATED TO BE 0.85, 0.04 CC AND 0.11 IN THE FRENCH DAIRY BREEDS 'ALPINE' AND 'SAANEN'. CC -!- SIMILARITY: Belongs to the alpha-casein family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X65160; CAA46278.1; -. DR EMBL; S74171; AAB32166.1; -. DR PIR; I46995; I46995. DR PIR; S33881; JN0547. DR InterPro; IPR001588; Casein. DR Pfam; PF00363; caseins; 2. DR PROSITE; PS00306; CASEIN_ALPHA_BETA; 1. KW Milk; Phosphorylation; Signal; Repeat; Polymorphism. FT SIGNAL 1 15 BY SIMILARITY. FT CHAIN 16 223 ALPHA-S2 CASEIN. FT REPEAT 77 141 FT REPEAT 159 223 FT MOD_RES 23 23 PHOSPHORYLATION (BY SIMILARITY). FT MOD_RES 24 24 PHOSPHORYLATION (BY SIMILARITY). FT MOD_RES 25 25 PHOSPHORYLATION (BY SIMILARITY). FT MOD_RES 72 72 PHOSPHORYLATION (BY SIMILARITY). FT MOD_RES 73 73 PHOSPHORYLATION (BY SIMILARITY). FT MOD_RES 74 74 PHOSPHORYLATION (BY SIMILARITY). FT MOD_RES 77 77 PHOSPHORYLATION (BY SIMILARITY). FT MOD_RES 145 145 PHOSPHORYLATION (BY SIMILARITY). FT MOD_RES 147 147 PHOSPHORYLATION (BY SIMILARITY). FT VARIANT 79 79 E -> K (IN VARIANT B). FT VARIANT 182 182 K -> I (IN VARIANT C). SQ SEQUENCE 223 AA; 26389 MW; 187DEF42FD688291 CRC64; MKFFIFTCLL AVALAKHKME HVSSSEEPIN IFQEIYKQEK NMAIHPRKEK LCTTSCEEVV RNANEEEYSI RSSSEESAEV APEEIKITVD DKHYQKALNE INQFYQKFPQ YLQYPYQGPI VLNPWDQVKR NAGPFTPTVN REQLSTSEEN SKKTIDMEST EVFTKKTKLT EEEKNRLNFL KKISQYYQKF AWPQYLKTVD QHQKAMKPWT QPKTNAIPYV RYL //