ID SWE1_YEAST STANDARD; PRT; 819 AA. AC P32944; DT 01-OCT-1993 (REL. 27, CREATED) DT 01-OCT-1993 (REL. 27, LAST SEQUENCE UPDATE) DT 01-NOV-1995 (REL. 32, LAST ANNOTATION UPDATE) DE MITOSIS INHIBITOR PROTEIN KINASE SWE1 (EC 2.7.1.-). GN SWE1 OR YJL187C. OS SACCHAROMYCES CEREVISIAE (BAKER'S YEAST). OC EUKARYOTA; FUNGI; ASCOMYCOTINA; HEMIASCOMYCETES. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 94074541. RA BOOHER R.N., DESHAIES R.J., KIRSCHNER M.W.; RL EMBO J. 12:3417-3426(1993). RN [2] RP SEQUENCE FROM N.A. RA OBERMAIER B., PIRAVANDI E., RINKE M., DOMDEY H.; RL SUBMITTED (SEP-1995) TO EMBL/GENBANK/DDBJ DATA BANKS. CC -!- FUNCTION: PROTEIN KINASE THAT ACTS BOTH ON SERINES AND ON CC TYROSINES. IT ACTS AS A NEGATIVE REGULATOR OF ENTRY INTO MITOSIS CC (G2 TO M TRANSITION). PHOSPHORYLATES AND INHIBITS CDC28. CC -!- SIMILARITY: WITH THE CONSERVED CATALYTIC DOMAINS OF SER/THR- CC PROTEIN KINASES. HIGHLY SIMILAR TO S.POMBE WEE1. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X73966; X73966. DR EMBL; Z49462; Z49462. DR PIR; S39999; S39999. DR PIR; S40400; S40400. DR LISTA; SC01260; SWE1. DR SGD; L0002248; SWE1. DR PROSITE; PS00107; PROTEIN_KINASE_ATP. DR PROSITE; PS00108; PROTEIN_KINASE_ST. DR PROSITE; PS50011; PROTEIN_KINASE_DOM. KW MITOSIS; TRANSFERASE; TYROSINE-PROTEIN KINASE; ATP-BINDING. FT DOMAIN 444 794 PROTEIN KINASE. FT NP_BIND 450 458 ATP (BY SIMILARITY). FT BINDING 473 473 ATP (BY SIMILARITY). FT ACT_SITE 579 579 BY SIMILARITY. SQ SEQUENCE 819 AA; 92467 MW; 3389677 CN; MSSLDEDEED FEMLDTENLQ FMGKKMFGKQ AGEDESDDFA IGGSTPTNKL KFYPYSNNKL TRSTGTLNLS LSNTALSEAN SKFLGKIEEE EEEEEEGKDE ESVDSRIKRW SPFHENESVT TPITKRSAEK TNSPISLKQW NQRWFPKNDA RTENTSSSSS YSVAKPNQSA FTSSGLVSKM SMDTSLYPAK LRIPETPVKK SPLVEGRDHK HVHLSSSKNA SSSLSVSPLN FVEDNNLQED LLFSDSPSSK ALPSIHVPTI DSSPLSEAKY HAHDRHNNQT NILSPTNSLV TNSSPQTLHS NKFKKIKRAR NSVILKNREL TNSLQQFKDD LYGTDENFPP PIIISSHHST RKNPQPYQFR GRYDNDTDEE ISTPTRRKSI IGATSQTHRE SRPLSLSSAI VTNTTSAETH SISSTDSSPL NSKRRLISSN KLSANPDSHL FEKFTNVHSI GKGQFSTVYQ VTFAQTNKKY AIKAIKPNKY NSLKRILLEI KILNEVTNQI TMDQEGKEYI IDYISSWKFQ NSYYIMTELC ENGNLDGFLQ EQVIAKKKRL EDWRIWKIIV ELSLALRFIH DSCHIVHLDL KPANVMITFE GNLKLGDFGM ATHLPLEDKS FENEGDREYI APEIISDCTY DYKADIFSLG LMIVEIAANV VLPDNGNAWH KLRSGDLSDA GRLSSTDIHS ESLFSDITKV DTNDLFDFER DNISGNSNNA GTSTVHNNSN INNPNMNNGN DNNNVNTAAT KNRLILHKSS KIPAWVPKFL IDGESLERIV RWMIEPNYER RPTANQILQT EECLYVEMTR NAGAIIQEDD FGPKPKFFI //