ID PR19_YEAST STANDARD; PRT; 503 AA. AC P32523; Q07870; DT 01-OCT-1993 (Rel. 27, Created) DT 01-OCT-1996 (Rel. 34, Last sequence update) DT 01-NOV-1997 (Rel. 35, Last annotation update) DE PRE-MRNA SPLICING FACTOR PRP19. GN PRP19 OR PSO4 OR YLL036C. OS Saccharomyces cerevisiae (Baker's yeast). OC Eukaryota; Fungi; Ascomycota; Saccharomycotina; Saccharomycetes; OC Saccharomycetales; Saccharomycetaceae; Saccharomyces. OX NCBI_TaxID=4932; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=93180836; PubMed=8441419; RA Cheng S.C., Tarn W.Y., Tsao T.Y., Abelson J.; RT "PRP19: a novel spliceosomal component."; RL Mol. Cell. Biol. 13:1876-1882(1993). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=97078680; PubMed=8918805; RA Grey M., Duesterhoeft A., Henriques J.A.P., Brendel M.; RT "Allelism of PSO4 and PRP19 links pre-mRNA processing with RT recombination and error-prone DNA repair in Saccharomyces RT cerevisiae."; RL Nucleic Acids Res. 24:4009-4014(1996). RN [3] RP SEQUENCE FROM N.A. RA Duesterhoeft A., Floeth M., Heuss-Neitzel D., Hilbert H., RA Moestl D.; RL Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases. RN [4] RP CHARACTERIZATION. RX MEDLINE=93180837; PubMed=7680101; RA Tarn W.Y., Lee K.R., Cheng S.C.; RT "The yeast PRP19 protein is not tightly associated with small nuclear RT RNAs, but appears to associate with the spliceosome after binding of RT U2 to the pre-mRNA and prior to formation of the functional RT spliceosome."; RL Mol. Cell. Biol. 13:1883-1891(1993). CC -!- FUNCTION: NOT KNOWN. APPEARS TO ASSOCIATE WITH THE SPLICEOSOME CC AFTER BINDING OF U2 TO THE PRE-MRNA AND PRIOR TO FORMATION OF CC THE FUNCTIONAL SPLICEOSOME. INVOLVED IN DNA REPAIR. CC -!- SUBCELLULAR LOCATION: NUCLEAR. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L09721; AAA34912.1; -. DR EMBL; X99770; CAA68103.1; -. DR EMBL; Z73142; CAA97487.1; -. DR PIR; S30798; S30798. DR PIR; A48155; A48155. DR SGD; S0003959; PRP19. DR InterPro; IPR003613; Ubox. DR SMART; SM00504; Ubox; 1. KW mRNA splicing; Spliceosome; Nuclear protein; DNA repair. FT CONFLICT 239 239 MISSING (IN REF. 1). SQ SEQUENCE 503 AA; 56570 MW; A44D8C7DD6F64185 CRC64; MLCAISGKVP RRPVLSPKSR TIFEKSLLEQ YVKDTGNDPI TNEPLSIEEI VEIVPSAQQA SLTESTNSAT LKANYSIPNL LTSLQNEWDA IMLENFKLRS TLDSLTKKLS TVMYERDAAK LVAAQLLMEK NEDSKDLPKS SQQAVAITRE EFLQGLLQSS RDFVARGKLK APKWPILKNL ELLQAQNYSR NIKTFPYKEL NKSMYYDKWV CMCRCEDGAL HFTQLKDSKT ITTITTPNPR TGGEHPAIIS RGPCNRLLLL YPGNQITILD SKTNKVLREI EVDSANEIIY MYGHNEVNTE YFIWADNRGT IGFQSYEDDS QYIVHSAKSD VEYSSGVLHK DSLLLALYSP DGILDVYNLS SPDQASSRFP VDEEAKIKEV KFADNGYWMV VECDQTVVCF DLRKDVGTLA YPTYTIPEFK TGTVTYDIDD SGKNMIAYSN ESNSLTIYKF DKKTKNWTKD EESALCLQSD TADFTDMDVV CGDGGIAAIL KTNDSFNIVA LTP //