ID GTR3_MOUSE Reviewed; 493 AA. AC P32037; DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot. DT 01-JUL-1993, sequence version 1. DT 09-JUL-2014, entry version 120. DE RecName: Full=Solute carrier family 2, facilitated glucose transporter member 3; DE AltName: Full=Glucose transporter type 3, brain; DE Short=GLUT-3; GN Name=Slc2a3; Synonyms=Glut-3, Glut3; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Brain; RX PubMed=1730609; RA Nagamatsu S., Kornhauser J.M., Seino S., Mayo K.E., Steiner D.F., RA Bell G.I.; RT "Glucose transporter expression in brain. cDNA sequence of mouse RT GLUT3, the brain facilitative glucose transporter isoform, and RT identification of sites of expression by in situ hybridization."; RL J. Biol. Chem. 267:467-472(1992). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Takeda J., Minokoshi Y., Yasuda K., Kayano T., Graeme B.I.; RT "Evolution of facilitative sugar transporter gene family: RT Characterization of mouse GLUT3 and human GLUT5 genes."; RL Submitted (JUL-1994) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Retina; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [4] RP PROTEIN SEQUENCE OF 218-228, AND IDENTIFICATION BY MASS SPECTROMETRY. RC STRAIN=C57BL/6; TISSUE=Brain; RA Lubec G., Kang S.U.; RL Submitted (APR-2007) to UniProtKB. RN [5] RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-43. RX PubMed=19349973; DOI=10.1038/nbt.1532; RA Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., RA Schiess R., Aebersold R., Watts J.D.; RT "Mass-spectrometric identification and relative quantification of N- RT linked cell surface glycoproteins."; RL Nat. Biotechnol. 27:378-386(2009). CC -!- FUNCTION: Facilitative glucose transporter. Probably a neuronal CC glucose transporter. CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Highly expressed in brain. CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar CC transporter (TC 2.A.1.1) family. Glucose transporter subfamily. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M75135; AAA37704.1; -; mRNA. DR EMBL; X61093; CAA43406.1; -; mRNA. DR EMBL; U11853; AAB60666.1; -; Genomic_DNA. DR EMBL; U11844; AAB60666.1; JOINED; Genomic_DNA. DR EMBL; U11845; AAB60666.1; JOINED; Genomic_DNA. DR EMBL; U11846; AAB60666.1; JOINED; Genomic_DNA. DR EMBL; U11848; AAB60666.1; JOINED; Genomic_DNA. DR EMBL; U11849; AAB60666.1; JOINED; Genomic_DNA. DR EMBL; U11850; AAB60666.1; JOINED; Genomic_DNA. DR EMBL; U11851; AAB60666.1; JOINED; Genomic_DNA. DR EMBL; U11852; AAB60666.1; JOINED; Genomic_DNA. DR EMBL; BC034122; AAH34122.1; -; mRNA. DR EMBL; BC058811; AAH58811.1; -; mRNA. DR CCDS; CCDS20502.1; -. DR PIR; A41751; A41751. DR RefSeq; NP_035531.3; NM_011401.4. DR UniGene; Mm.395108; -. DR ProteinModelPortal; P32037; -. DR SMR; P32037; 9-466. DR PhosphoSite; P32037; -. DR MaxQB; P32037; -. DR PaxDb; P32037; -. DR PRIDE; P32037; -. DR Ensembl; ENSMUST00000032476; ENSMUSP00000032476; ENSMUSG00000003153. DR GeneID; 20527; -. DR KEGG; mmu:20527; -. DR UCSC; uc009dpq.2; mouse. DR CTD; 6515; -. DR MGI; MGI:95757; Slc2a3. DR eggNOG; COG0477; -. DR HOGENOM; HOG000202871; -. DR HOVERGEN; HBG014816; -. DR InParanoid; P32037; -. DR KO; K08142; -. DR OMA; FEDITRV; -. DR OrthoDB; EOG7QVM2R; -. DR PhylomeDB; P32037; -. DR TreeFam; TF313762; -. DR ChiTaRS; SLC2A3; mouse. DR NextBio; 298771; -. DR PRO; PR:P32037; -. DR ArrayExpress; P32037; -. DR Bgee; P32037; -. DR Genevestigator; P32037; -. DR GO; GO:0002080; C:acrosomal membrane; IDA:MGI. DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB. DR GO; GO:0055056; F:D-glucose transmembrane transporter activity; IDA:UniProtKB. DR GO; GO:0033300; F:dehydroascorbic acid transporter activity; IDA:UniProtKB. DR GO; GO:0070837; P:dehydroascorbic acid transport; IDA:UniProtKB. DR GO; GO:0015758; P:glucose transport; IDA:UniProtKB. DR InterPro; IPR002945; Glc_transpt_3. DR InterPro; IPR020846; MFS_dom. DR InterPro; IPR016196; MFS_dom_general_subst_transpt. DR InterPro; IPR005828; Sub_transporter. DR InterPro; IPR003663; Sugar/inositol_transpt. DR InterPro; IPR005829; Sugar_transporter_CS. DR Pfam; PF00083; Sugar_tr; 1. DR PRINTS; PR01192; GLUCTRSPORT3. DR PRINTS; PR00171; SUGRTRNSPORT. DR SUPFAM; SSF103473; SSF103473; 2. DR TIGRFAMs; TIGR00879; SP; 1. DR PROSITE; PS50850; MFS; 1. DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1. DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1. PE 1: Evidence at protein level; KW Complete proteome; Direct protein sequencing; Glycoprotein; Membrane; KW Reference proteome; Sugar transport; Transmembrane; KW Transmembrane helix; Transport. FT CHAIN 1 493 Solute carrier family 2, facilitated FT glucose transporter member 3. FT /FTId=PRO_0000050354. FT TOPO_DOM 1 10 Cytoplasmic (Potential). FT TRANSMEM 11 31 Helical; Name=1; (Potential). FT TOPO_DOM 32 64 Extracellular (Potential). FT TRANSMEM 65 85 Helical; Name=2; (Potential). FT TOPO_DOM 86 93 Cytoplasmic (Potential). FT TRANSMEM 94 114 Helical; Name=3; (Potential). FT TOPO_DOM 115 124 Extracellular (Potential). FT TRANSMEM 125 145 Helical; Name=4; (Potential). FT TOPO_DOM 146 153 Cytoplasmic (Potential). FT TRANSMEM 154 174 Helical; Name=5; (Potential). FT TOPO_DOM 175 183 Extracellular (Potential). FT TRANSMEM 184 204 Helical; Name=6; (Potential). FT TOPO_DOM 205 269 Cytoplasmic (Potential). FT TRANSMEM 270 290 Helical; Name=7; (Potential). FT TOPO_DOM 291 304 Extracellular (Potential). FT TRANSMEM 305 325 Helical; Name=8; (Potential). FT TOPO_DOM 326 334 Cytoplasmic (Potential). FT TRANSMEM 335 355 Helical; Name=9; (Potential). FT TOPO_DOM 356 363 Extracellular (Potential). FT TRANSMEM 364 384 Helical; Name=10; (Potential). FT TOPO_DOM 385 399 Cytoplasmic (Potential). FT TRANSMEM 400 420 Helical; Name=11; (Potential). FT TOPO_DOM 421 427 Extracellular (Potential). FT TRANSMEM 428 448 Helical; Name=12; (Potential). FT TOPO_DOM 449 493 Cytoplasmic (Potential). FT REGION 277 279 Defines substrate specificity (By FT similarity). FT CARBOHYD 43 43 N-linked (GlcNAc...). SQ SEQUENCE 493 AA; 53479 MW; 9090B8DCB8780082 CRC64; MGTTKVTPSL VFAVTVATIG SFQFGYNTGV INAPETILKD FLNYTLEERL EDLPSEGLLT ALWSLCVAIF SVGGMIGSFS VGLFVNRFGR RNSMLLVNLL AIIAGCLMGF AKIAESVEML ILGRLLIGIF CGLCTGFVPM YIGEVSPTAL RGAFGTLNQL GIVVGILVAQ IFGLDFILGS EELWPGLLGL TIIPAILQSA ALPFCPESPR FLLINKKEED QATEILQRLW GTSDVVQEIQ EMKDESVRMS QEKQVTVLEL FRSPNYVQPL LISIVLQLSQ QLSGINAVFY YSTGIFKDAG VQEPIYATIG AGVVNTIFTV VSLFLVERAG RRTLHMIGLG GMAVCSVFMT ISLLLKDDYE AMSFVCIVAI LIYVAFFEIG PGPIPWFIVA ELFSQGPRPA AIAVAGCCNW TSNFLVGMLF PSAAAYLGAY VFIIFAAFLI FFLIFTFFKV PETKGRTFED IARAFEGQAH SGKGPAGVEL NSMQPVKETP GNA //