ID ZEP2_HUMAN STANDARD; PRT; 1833 AA. AC P31629; DT 01-JUL-1993 (Rel. 26, Created) DT 01-JUL-1993 (Rel. 26, Last sequence update) DT 15-JUL-1998 (Rel. 36, Last annotation update) DE HUMAN IMMUNODEFICIENCY VIRUS TYPE I ENHANCER-BINDING PROTEIN 2 DE (HIV-EP2). GN HIVEP2. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia; OC Eutheria; Primates; Catarrhini; Hominidae; Homo. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 91217105. RA NOMURA N., ZHAO M.-J., NAGASE T., MAEKAWA T., ISHIZAKI R., TABATA S., RA ISHII S.; RT "HIV-EP2, a new member of the gene family encoding the human RT immunodeficiency virus type 1 enhancer-binding protein. Comparison RT with HIV-EP1/PRDII-BF1/MBP-1."; RL J. Biol. Chem. 266:8590-8594(1991). RN [2] RP SEQUENCE OF 1184-1323 FROM N.A. RX MEDLINE; 91062349. RA RUSTGI A.K., VAN'T VEER L.J., BERNARDS R.; RT "Two genes encode factors with NF-kappa B- and H2TF1-like DNA-binding RT properties."; RL Proc. Natl. Acad. Sci. U.S.A. 87:8707-8710(1990). CC -!- FUNCTION: THIS PROTEIN SPECIFICALLY BINDS TO THE DNA SEQUENCE CC 5'-GGGACTTTCC-3' WHICH IS FOUND IN THE ENHANCER ELEMENTS OF CC NUMEROUS VIRAL PROMOTERS SUCH AS THOSE OF SV40, CMV, OR HIV1. CC IN ADDITION, RELATED SEQUENCES ARE FOUND IN THE ENHANCER ELEMENTS CC OF A NUMBER OF CELLULAR PROMOTERS, INCLUDING THOSE OF THE CLASS I CC MHC, INTERLEUKIN-2 RECEPTOR, AND INTERFERON-BETA GENES. IT MAY ACT CC IN T-CELL ACTIVATION. CC -!- SUBCELLULAR LOCATION: NUCLEAR. CC -!- INDUCTION: BY MITOGEN AND PHORBOL ESTER. CC -!- SIMILARITY: STRONG, TO HIVEP1. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M60119; AAB88218.1; -. DR EMBL; M61744; AAA36202.1; -. DR PIR; A39829; WMHUE2. DR HSSP; P15822; 1BBO. DR TRANSFAC; T00939; -. DR MIM; 143054; -. DR PFAM; PF00096; zf-C2H2; 2. DR PROSITE; PS00028; ZINC_FINGER_C2H2; 2. KW Transcription regulation; Zinc-finger; Metal-binding; DNA-binding; KW Nuclear protein. FT DOMAIN 324 330 NUCLEAR LOCALIZATION SIGNAL (POTENTIAL). FT DOMAIN 337 369 SER-RICH. FT DOMAIN 1286 1310 ASP/GLU-RICH (ACIDIC). FT ZN_FING 1186 1208 C2H2-TYPE. FT ZN_FING 1214 1238 C2H2-TYPE. SQ SEQUENCE 1833 AA; 202128 MW; F0A5D053 CRC32; MLKGISSSSL KEKKLSPGDR VGYDYDVCRK PYKKWEDSET PKQNYRDISC LSSLKHGGEY FMDPVVPLQG VPSMFGTTCE NRKRRKEKSV GDEEDTPMIC SSIVSTPVGI MASDYDPKLQ MQEGVRSGFA MAGHENLSHG HTERFDPCRP QLQPGSPSLV SEESPSAIDS DKMSDLGGRK PPGNVISVIQ HTNSLSRPNS FERSESAELV ACTQDKAPSP SETCDSEISE APVSPEWAPP GDGAESGGKP SPSQQVQQQS YHTQPRLVRQ HNIQVPEIRV TEEPDKPEKE KEAQSKEPEK PVEEFQWPQR SETLSQLPAE KLPPKKKRLR LADMEHSSGE SSFESTGTGL SRSPSQESNL SHSSSFSMSF EREETSKLSA LPKQDEFGKH SEFLTVPAGS YSLSVPGHHH QKEMRRCSSE QMPCPHPAEV PEVRSKSFDY GNLSHAPVSG AAASTVSPSR ERKKCFLVRQ ASFSGSPEIS QGEVGMDQSV KQEQLEHLHA GLRSGWHHGP PAVLPPLQQE DPGKQVAGPC PPLSSGPLHL AQPQIMHMDS QESLRNPLIQ PTSYMTSKHL PEQPHLFPHQ ETIPFSPIQN ALFQFQYPTV CMVHLPAQQP PWWQAHFPHP FAQHPQKSYG KPSFQTEIHS SYPLEHVAEH TGKKPAEYAH TKEQTYPCYS GASGLHPKNL LPKFPSDQSS KSTETPSEQV LQEDFASANA GSLQSLPGTV VPVRIQTHVP SYGSVMYTSI SQILGQNSPA IVICKVDENM TQRTLVTNAA MQGIGFNIAQ VLGQHAGLEK YPIWKAPQTL PLGLESSIPL CLPSTSDSVA TLGGSKRMLS PASSLELFME TKQQKRVKEE KMYGQIVEEL SAVELTNSDI KKDLSRPQKP QLVRQGCASE PKDGLQSGSS SFSSLSPSSS QDYPSVSPSS REPFPPSKEM LSGSRAPLPG QKSSGPSESK ESSDELDIDE TASDMSMSPQ SSSLPAGDGQ LEEEGKGHKR PVGMLVRMAS APSGNVADST LLLTDMADFQ QILQFPSLRT TTTVSWCFLN YTKPNYVQQA TFKSSVYASW CISSCNPNPS GLNTKTTLAL LRSKQKITAE IYTLAAMHRP GTGKLTSSSA WKQFTQMKPD ASFLFGSKLE RKLVGNILKE RGKGDIHGDK DIGSKQTEPI RIKIFEGGYK SNEDYVYVRG RGRGKYICEE CGIRCKKPSM LKKHIRTHTD VRPYVCKLCN FAFKTKGNLT KHMKSKAHMK KCLELGVSMT SVDDTETEEA ENLEDLHKAA EKHSMSSIST DHQFSDAEES DGEDGDDNDD DDEDEDDFDD QGDLTPKTRS RSTSPQPPRF SSLPVNVGAV PHGVPSDSSL GHSSLISYLV TLPSIRVTQL MTPSDSCEDT QMTEYQRLFQ SKSTDSEPDK DRLDIPSCMD EECMLPSEPS SSPRDFSPSS HHSSPGYDSS PCRDNSPKRY LIPKGDLSPR RHLSPRRDLS PMRHLSPRKE AALRREMSQR DVSPRRHLSP RRPVSPGKDI TARRDLSPRR ERRYMTTIRA PSPRRALYHN PPLSMGQYLQ AEPIVLGPPN LRRGLPQVPY FSLYGDQEGA YEHPGSSLFP EGPNDYVFSH LPLHSQQQVR APIPMVPVGG IQMVHSMPPA LSSLHPSPTL PLPMEGFEEK KGASGESFSK DPYVLSKQHE KRGPHALQSS GPPSTPSSPR LLMKQSTSED SLNATEREQE ENIQTCTKAI ASLRIATEEA ALLGPDQPAR VQEPHQNPLG SAHVSIRHFS RPEPGQPCTS ATHPDLHDGE KDNFGTSQTP LAHSTFYSKS CVDDKQLDFH SSKELSSSTE ESKDPSSEKS QLH //