ID GLT1_RAT STANDARD; PRT; 573 AA. AC P31596; DT 01-JUL-1993 (REL. 26, CREATED) DT 01-JUL-1993 (REL. 26, LAST SEQUENCE UPDATE) DT 01-JUL-1993 (REL. 26, LAST ANNOTATION UPDATE) DE BRAIN SODIUM-DEPENDENT GLUTAMATE/ASPARTATE TRANSPORTER. GN GLT-1. OS RATTUS NORVEGICUS (RAT). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; RODENTIA. RN [1] RP SEQUENCE FROM N.A. RC TISSUE=BRAIN; RM 93078876 RA PINES G., DANBOLT N.C., BJORAS M., ZHANG Y., BENDAHAN A., EIDE L., RA KOEPSELL H., STORM-MATHISEN J., SEEBERG E., KANNER B.I.; RL NATURE 360:464-467(1992). CC -!- FUNCTION: TRANSPORTS L-GLUTAMATE AND ALSO L- AND D-ASPARTATE. CC ESSENTIAL FOR TERMINATING THE POSTSYNAPTIC ACTION OF GLUTAMATE BY CC RAPIDLY REMOVING RELEASED GLUTAMATE FROM THE SYNAPTIC CLEFT. ACTS CC AS A SYMPORT BY CO-TRANSPORTING SODIUM. CC -!- PTM: IT IS A GLYCOPROTEIN. CC -!- SUBCELLULAR LOCATION: INTEGRAL MEMBRANE PROTEIN. CC -!- TISSUE SPECIFICITY: LOCALIZED IN BRAIN AND IS HIGHLY ENRICHED IN CC THE PURKINJE CELL LAYER IN CEREBELLUM. CC -!- SIMILARITY: BELONGS TO THE SODIUM:DICARBOXYLATE SYMPORTER FAMILY CC (SDF). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X67857; RNGLT. DR EMBL; S49853; S49853. KW TRANSPORT; TRANSMEMBRANE; GLYCOPROTEIN; SYMPORT. FT TRANSMEM 45 64 POTENTIAL. FT TRANSMEM 88 108 POTENTIAL. FT TRANSMEM 121 142 POTENTIAL. FT TRANSMEM 241 260 POTENTIAL. FT TRANSMEM 285 302 POTENTIAL. FT TRANSMEM 316 338 POTENTIAL. FT TRANSMEM 405 429 POTENTIAL. FT TRANSMEM 436 458 POTENTIAL. FT CARBOHYD 205 205 POTENTIAL. FT CARBOHYD 215 215 POTENTIAL. SQ SEQUENCE 573 AA; 61674 MW; 1707166 CN; MASTEGANNM PKQVEVRMHD SHLSSEEPKH RNLGMRMCDK LGKNLLLSLT VFGVILGAVC GGLLRLAAPI HPDVVMLIAF PGDILMRMLK MLILPLIISS LITGLSGLDA KASGRLGTRA MVYYMSTTII AAVLGVILVL AIHPGNPKLK KQLGPGKKND EVSSLDAFLD LIRNLFPENL VQACFQQIQT VTKKVLVAPP SEEANTTKAV ISLLNETMNE APEETKIVIK KGLEFKDGMN VLGLIGFFIA FGIAMGKMGV AGQADGGVLQ HSERDCHEVS DHDHVVFPAG IACLICGKII AIKDLEVVAR QLGMYMITVI VGLIIHGGIF LPLIYFVVTR KNPFSFFAGI FQAWITALGT ASSAGTLPVT FRCLEDNLGI DKRVTRFVLP VGATINMDGT ALYEAVAAIF IAQMNGVILD GGQIVTVSLT ATLASIGAAS IPSAGLVTML LILTAVGLPT EDISLLVAVD WLLDRMRTSV NVVGDSFGAG IVYHLSKSEL DTIDSQHRMH EDIEMTKTQS VYDDTKNHRE SNSNQCVYAA HNSVVIDECK VTLAANGKSA DCSVEEEPWK REK //