ID VAT2_BOVIN STANDARD; PRT; 511 AA. AC P31408; Q28058; DT 01-JUL-1993 (REL. 26, CREATED) DT 01-JUN-1994 (REL. 29, LAST SEQUENCE UPDATE) DT 01-NOV-1997 (REL. 35, LAST ANNOTATION UPDATE) DE VACUOLAR ATP SYNTHASE SUBUNIT B, BRAIN ISOFORM (EC 3.6.1.34) DE (ENDOMEMBRANE PROTON PUMP 58 KD SUBUNIT) (V-ATPASE B SUBUNIT). GN ATP6B2. OS BOS TAURUS (BOVINE). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; ARTIODACTYLA. RN [1] RP SEQUENCE FROM N.A. RC TISSUE=BRAIN; RX MEDLINE; 92228822. RA NELSON R.D., GUO X.-L., MASOOD K., BROWN D., KALKBRENNER M., RA GLUCK S.; RL PROC. NATL. ACAD. SCI. U.S.A. 89:3541-3545(1992). RN [2] RP SEQUENCE FROM N.A., AND SEQUENCE OF 30-58. RC TISSUE=BRAIN; RX MEDLINE; 92156101. RA PUOPOLO K., KUMAMOTO C., ADACHI I., MAGNER R., FORGAC M.; RL J. BIOL. CHEM. 267:3696-3706(1992). RN [3] RP SEQUENCE FROM N.A. RX MEDLINE; 92070583. RA PAN Y.X., XU J., STRASSER J.E., HOWELL M., DEAN G.E.; RL FEBS LETT. 293:89-92(1991). CC -!- FUNCTION: VACUOLAR ATPASE IS RESPONSIBLE FOR ACIDIFYING A VARIETY CC OF INTRACELLULAR COMPARTMENTS IN EUKARYOTIC CELLS. THE B SUBUNIT CC IS NONCATALYTIC BUT COMBINES WITH OTHER SUBUNITS TO FORM THE CC CATALYTIC COMPLEX. CC -!- SUBUNIT: COMPOSED OF AT LEAST 10 SUBUNITS. CC -!- SUBCELLULAR LOCATION: ENDOMEMBRANE. CC -!- TISSUE SPECIFICITY: IN ALL TISSUES TESTED, BUT HIGHEST IN BRAIN CC AND IN ADRENAL MEDULLA. CC -!- SIMILARITY: TO THE ALPHA CHAINS OF ATP SYNTHASES AND TO A LESSER CC EXTENT TO THE BETA CHAINS. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M88690; G162723; -. DR EMBL; M83131; G162703; -. DR EMBL; X58385; G297129; -. DR PIR; A42254; A42254. DR PIR; S32614; S32614. DR PROSITE; PS00152; ATPASE_ALPHA_BETA; 1. KW HYDROLASE; HYDROGEN ION TRANSPORT; MULTIGENE FAMILY. FT CONFLICT 24 24 MISSING (IN REF. 1). FT CONFLICT 83 83 S -> T (IN REF. 2). FT CONFLICT 161 162 QC -> HF (IN REF. 1). FT CONFLICT 250 250 Q -> E (IN REF. 1 AND 2). FT CONFLICT 460 460 R -> K (IN REF. 1). FT CONFLICT 464 464 A -> T (IN REF. 1). FT CONFLICT 510 511 KH -> NS (IN REF. 2). SQ SEQUENCE 511 AA; 56575 MW; 7045DD07 CRC32; MALRAMRGIV NGAAPELPVP TSGPLAGSRE QALAVSRNYL SQPRLTYKTV SGVNGPLVIL DHVKFPRYAE IVHLTLPDGT KRSGQVLEVS GSKAVVQVFE GTSGIDAKKT SCEFTGDILR TPVSEDMLGR VFNGSGKPID RGPVVLAEDF LDIMGQPINP QCRIYPEEMI QTGISAIDGM NSIARGQKIP IFSAAGLPHN EIAAQICRQA GLVKKSKDVV DYSEENFAIV FAAMGVNMET ARFFKSDFEQ NGSMDNVCLF LNLANDPTIE RIITPRLALT TAEFLAYQCE KHVLVILTDM SSYAEALREV SAAREEVPGR RGFPGYMYTD LATIYERAGR VEGRNGSITQ IPILTMPNDD ITHPIPDLTG YITEGQIYVD RQLHNRQIYP PINVLPSLSR LMKSAIGEGM TRKDHADVSN QLYACYAIGK DVQAMKAVVG EEALTSDDLL YLEFLQKFER NFIAQGPYEN RTVYETLDIG WQLLRIFPKE MLKRIPQSTL SEFYPRDSAK H //