ID VAT2_BOVIN STANDARD; PRT; 511 AA. AC P31408; Q28058; DT 01-JUL-1993 (Rel. 26, Created) DT 01-JUN-1994 (Rel. 29, Last sequence update) DT 15-JUL-1998 (Rel. 36, Last annotation update) DE VACUOLAR ATP SYNTHASE SUBUNIT B, BRAIN ISOFORM (EC 3.6.1.34) DE (ENDOMEMBRANE PROTON PUMP 58 KD SUBUNIT) (V-ATPASE B SUBUNIT). GN ATP6B2. OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia; OC Eutheria; Cetartiodactyla; Ruminantia; Pecora; Bovoidea; Bovidae; OC Bovinae; Bos. RN [1] RP SEQUENCE FROM N.A. RC TISSUE=BRAIN; RX MEDLINE; 92228822. RA NELSON R.D., GUO X.-L., MASOOD K., BROWN D., KALKBRENNER M., RA GLUCK S.; RT "Selectively amplified expression of an isoform of the vacuolar H(+)- RT ATPase 56-kilodalton subunit in renal intercalated cells."; RL Proc. Natl. Acad. Sci. U.S.A. 89:3541-3545(1992). RN [2] RP SEQUENCE FROM N.A., AND SEQUENCE OF 30-58. RC TISSUE=BRAIN; RX MEDLINE; 92156101. RA PUOPOLO K., KUMAMOTO C., ADACHI I., MAGNER R., FORGAC M.; RT "Differential expression of the 'B' subunit of the vacuolar RT H(+)-ATPase in bovine tissues."; RL J. Biol. Chem. 267:3696-3706(1992). RN [3] RP SEQUENCE FROM N.A. RX MEDLINE; 92070583. RA PAN Y.X., XU J., STRASSER J.E., HOWELL M., DEAN G.E.; RT "Structure and expression of subunit A from the bovine chromaffin RT cell vacuolar ATPase."; RL FEBS Lett. 293:89-92(1991). CC -!- FUNCTION: NONCATALYTIC SUBUNIT OF THE PERIPHERAL V1 COMPLEX OF CC VACUOLAR ATPASE. V-ATPASE IS RESPONSIBLE FOR ACIDIFYING A VARIETY CC OF INTRACELLULAR COMPARTMENTS IN EUKARYOTIC CELLS. CC -!- SUBUNIT: V-ATPASE IS AN HETEROMULTIMERIC ENZYME COMPOSED OF A CC PERIPHERAL CATALYTIC V1 COMPLEX (MAIN COMPONENTS: SUBUNITS A, B, CC C, D, E, AND F) ATTACHED TO AN INTEGRAL MEMBRANE V0 PROTON PORE CC COMPLEX (MAIN COMPONENT: THE PROTEOLIPID PROTEIN). CC -!- SUBCELLULAR LOCATION: ENDOMEMBRANE. CC -!- TISSUE SPECIFICITY: IN ALL TISSUES TESTED, BUT HIGHEST IN BRAIN CC AND IN ADRENAL MEDULLA. CC -!- SIMILARITY: TO THE ALPHA CHAINS OF ATP SYNTHASES AND TO A LESSER CC EXTENT TO THE BETA CHAINS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M88690; AAA30400.1; -. DR EMBL; M83131; AAA30391.1; -. DR EMBL; X58385; CAA41275.1; -. DR PIR; A42254; A42254. DR PIR; S32614; S32614. DR PFAM; PF00006; ATP-synt_ab; 1. DR PFAM; PF01038; ATP_synt_B_c; 1. DR PROSITE; PS00152; ATPASE_ALPHA_BETA; 1. KW Hydrolase; Hydrogen ion transport; Multigene family. FT CONFLICT 24 24 MISSING (IN REF. 1). FT CONFLICT 83 83 S -> T (IN REF. 2). FT CONFLICT 161 162 QC -> HF (IN REF. 1). FT CONFLICT 250 250 Q -> E (IN REF. 1 AND 2). FT CONFLICT 460 460 R -> K (IN REF. 1). FT CONFLICT 464 464 A -> T (IN REF. 1). FT CONFLICT 510 511 KH -> NS (IN REF. 2). SQ SEQUENCE 511 AA; 56575 MW; 7045DD07 CRC32; MALRAMRGIV NGAAPELPVP TSGPLAGSRE QALAVSRNYL SQPRLTYKTV SGVNGPLVIL DHVKFPRYAE IVHLTLPDGT KRSGQVLEVS GSKAVVQVFE GTSGIDAKKT SCEFTGDILR TPVSEDMLGR VFNGSGKPID RGPVVLAEDF LDIMGQPINP QCRIYPEEMI QTGISAIDGM NSIARGQKIP IFSAAGLPHN EIAAQICRQA GLVKKSKDVV DYSEENFAIV FAAMGVNMET ARFFKSDFEQ NGSMDNVCLF LNLANDPTIE RIITPRLALT TAEFLAYQCE KHVLVILTDM SSYAEALREV SAAREEVPGR RGFPGYMYTD LATIYERAGR VEGRNGSITQ IPILTMPNDD ITHPIPDLTG YITEGQIYVD RQLHNRQIYP PINVLPSLSR LMKSAIGEGM TRKDHADVSN QLYACYAIGK DVQAMKAVVG EEALTSDDLL YLEFLQKFER NFIAQGPYEN RTVYETLDIG WQLLRIFPKE MLKRIPQSTL SEFYPRDSAK H //