ID VAT2_BOVIN STANDARD; PRT; 510 AA. AC P31408; DT 01-JUL-1993 (REL. 26, CREATED) DT 01-JUL-1993 (REL. 26, LAST SEQUENCE UPDATE) DT 01-JUL-1993 (REL. 26, LAST ANNOTATION UPDATE) DE VACUOLAR ATP SYNTHASE SUBUNIT B, BRAIN ISOFORM (EC 3.6.1.34) DE (ENDOMEMBRANE PROTON PUMP 58 KD SUBUNIT) (V-ATPASE B SUBUNIT). OS BOS TAURUS (BOVINE). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; ARTIODACTYLA. RN [1] RP SEQUENCE FROM N.A. RC TISSUE=BRAIN; RM 92228822 RA NELSON R.D., GUO X.L., MASOOD K., BROWN D., KALKBRENNER M., RA GLUCK S.; RL PROC. NATL. ACAD. SCI. U.S.A. 89:3541-3545(1992). RN [2] RP SEQUENCE FROM N.A. RC TISSUE=BRAIN; RM 92156101 RA PUOPOLO K., KUMAMOTO C., ADACHI I., MAGNER R., FORGAC M.; RL J. BIOL. CHEM. 267:3696-3706(1992). CC -!- FUNCTION: VACUOLAR ATPASE IS RESPONSIBLE FOR ACIDIFYING A VARIETY CC OF INTRACELLULAR COMPARTMENTS IN EUKARYOTIC CELLS. THE B SUBUNIT CC IS NONCATALYTIC BUT COMBINES WITH OTHER SUBUNITS TO FORM THE CC CATALYTIC COMPLEX. CC -!- SUBUNIT: COMPOSED OF AT LEAST 10 SUBUNITS. CC -!- SUBCELLULAR LOCATION: ENDOMEMBRANE. CC -!- SIMILARITY: TO THE ALPHA CHAINS OF ATP SYNTHASES AND TO A LESSER CC LEVEL TO THE BETA CHAINS. CC -!- SIMILARITY: 90% IDENTICAL TO THE KIDNEY B SUBUNIT ISOFORM. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M88690; BTATPX. DR PIR; A42254; A42254. KW HYDROLASE; HYDROGEN ION TRANSPORT; MULTIGENE FAMILY. FT CONFLICT 23 23 G -> GP (IN REF. 2). FT CONFLICT 82 82 S -> T (IN REF. 2). FT CONFLICT 160 161 HF -> QC (IN REF. 2). FT CONFLICT 459 459 K -> R (IN REF. 2). FT CONFLICT 463 463 T -> A (IN REF. 2). FT CONFLICT 509 510 KH -> NS (IN REF. 2). SQ SEQUENCE 510 AA; 56534 MW; 1320330 CN; MALRAMRGIV NGAAPELPVP TSGLAGSREQ ALAVSRNYLS QPRLTYKTVS GVNGPLVILD HVKFPRYAEI VHLTLPDGTK RSGQVLEVSG SKAVVQVFEG TSGIDAKKTS CEFTGDILRT PVSEDMLGRV FNGSGKPIDR GPVVLAEDFL DIMGQPINPH FRIYPEEMIQ TGISAIDGMN SIARGQKIPI FSAAGLPHNE IAAQICRQAG LVKKSKDVVD YSEENFAIVF AAMGVNMETA RFFKSDFEEN GSMDNVCLFL NLANDPTIER IITPRLALTT AEFLAYQCEK HVLVILTDMS SYAEALREVS AAREEVPGRR GFPGYMYTDL ATIYERAGRV EGRNGSITQI PILTMPNDDI THPIPDLTGY ITEGQIYVDR QLHNRQIYPP INVLPSLSRL MKSAIGEGMT RKDHADVSNQ LYACYAIGKD VQAMKAVVGE EALTSDDLLY LEFLQKFEKN FITQGPYENR TVYETLDIGW QLLRIFPKEM LKRIPQSTLS EFYPRDSAKH //