ID CTD1_MOUSE STANDARD; PRT; 911 AA. AC P30999; DT 01-JUL-1993 (Rel. 26, Created) DT 01-JUL-1993 (Rel. 26, Last sequence update) DT 05-JUL-2004 (Rel. 44, Last annotation update) DE Catenin delta-1 (p120 catenin) (p120(ctn)) (Cadherin-associated Src DE substrate) (CAS) (p120(cas)). GN Name=CTNND1; Synonyms=Catns; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=Swiss; RX MEDLINE=93096477; PubMed=1334250; RA Reynolds A.B., Herbert L., Cleveland J.L., Berg S.T., Gaut J.R.; RT "p120, a novel substrate of protein tyrosine kinase receptors and of RT p60v-src, is related to cadherin-binding factors beta-catenin, RT plakoglobin and armadillo."; RL Oncogene 7:2439-2445(1992). RN [2] RP REVISIONS. RA Reynolds A.B.; RL Submitted (DEC-1992) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Efficient tyrosine kinase substrate implicated both in CC cell transformation by SRC and in ligand-induced receptor CC signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (By CC similarity). CC -!- SUBUNIT: Binds to the cytoplasmic domain of the cell-cell adhesion CC molecule E-cadherin. The association of catenins to cadherins CC produces a complex which is linked to the actin filament network, CC and which seems to be of primary importance for cadherins cell- CC adhesion properties (By similarity). CC -!- SUBCELLULAR LOCATION: Cytoplasmic and nuclear in particular cells CC (By similarity). CC -!- PTM: Phosphorylated by protein-tyrosine kinases. CC -!- SIMILARITY: Belongs to the beta-catenin family. CC -!- SIMILARITY: Contains 10 ARM repeats. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; Z17804; CAA79078.1; -. DR PIR; I48701; S28498. DR MGD; MGI:105100; Catns. DR InterPro; IPR008938; ARM. DR InterPro; IPR000225; Armadillo. DR Pfam; PF00514; Arm; 4. DR SMART; SM00185; ARM; 6. DR PROSITE; PS50176; ARM_REPEAT; 3. KW Cytoskeleton; Structural protein; Phosphorylation; Repeat; KW Cell adhesion; Coiled coil; Nuclear protein. FT DOMAIN 10 46 Coiled coil (Potential). FT REPEAT 358 395 ARM 1. FT REPEAT 398 437 ARM 2. FT REPEAT 441 475 ARM 3. FT REPEAT 476 516 ARM 4. FT REPEAT 534 573 ARM 5. FT REPEAT 583 624 ARM 6. FT REPEAT 647 687 ARM 7. FT REPEAT 694 733 ARM 8. FT REPEAT 734 774 ARM 9. FT REPEAT 775 820 ARM 10. FT DOMAIN 622 628 Nuclear localization signal (Potential). SQ SEQUENCE 911 AA; 101731 MW; EE18C6223948DDD1 CRC64; MDDSEVESTA SILASVKEQE AQFEKLTRAL EEERRHVSAQ LERVRVSPQD ANSLMANGTL TRRHQNGRFV GDADLERQKF SDLKLNGPQD HNHLLYSTIP RMQEPGQIVE TYTEEDPEGA MSVVSVETTD DGTTRRTETT VKKVVKTMTT RTVQPVPMGP DGLPVDASAV SNNYIQTLGR DFRKNGNGGP GPYVGQAGTA TLPRNFHYPP DGYGRHYEDG YPGGSDNYGS LSRVTRIEER YRPSMEGYRA PSRQDVYGPQ PQVRVGGSSV DLHRFHPEPY GLEDDQRSMG YDDLDYGMMS DYGTARRTGT PSDPRRRLRS YEDMIGEEVP PDQYYWAPLA QHERGSLASL DSLRKGMPPP SNWRQPELPE VIAMLGFRLD AVKSNAAAYL QHLCYRNDKV KTDVAKLKGI PILVGLLDHP KKEVHLGACG ALKNISFGRD QDNKIAIKNC DGVPALVRLL RKARDMDLTE VITGTLWNLS SHDSIKMEIV DHALHALTDE VIIPHSGWER EPNEDCKPRH IEWESVLTNT AGCLRNVSSE RSEARRKLRE CDGLVDALIF IVQAEIGQKD SDSKLVENCV CLLRNLSYQV HREIPQAERY QEALPTVANS TGPHAASCFG AKKGKGKKPT EDPANDTVDF PKRTSPARGY ELLFQPEVVR IYISLLKESN TPAILEASAG AIQNLCAGRW TYGRYIRSAL RQEKALSARA ELLTSEHERV VKAASGALRN LAVDARNKEL IGKHARPNLV KNLPGGQQNS SWNFSEDTVV SILNTINEVI AENLEAAKKL RETQGIEKLV LINKSGNRSE KEVRAAALVL QTIWGYKELR KPLEKEGWKK SDFQVNLNNA SRSQSSHSYD DSTLPLIDRN QKSDNNYSTL NERGDHNRTL DRSGDLGDME PLKGAPLMQK I //