ID   O10J1_HUMAN             Reviewed;         320 AA.
AC   P30954; Q2M1M8; Q5VSV1; Q6IET5; Q96R56;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   23-MAR-2010, sequence version 2.
DT   27-NOV-2024, entry version 198.
DE   RecName: Full=Olfactory receptor 10J1;
DE   AltName: Full=Olfactory receptor OR1-26;
DE   AltName: Full=Olfactory receptor-like protein HGMP07J;
GN   Name=OR10J1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ILE-62 AND MET-103.
RC   TISSUE=Testis;
RX   PubMed=1370859; DOI=10.1038/355453a0;
RA   Parmentier M., Libert F., Schurmans S., Schiffmann S., Lefort A.,
RA   Eggerickx D., Ledent C., Mollereau C., Gerard C., Perret J., Grootegoed A.,
RA   Vassart G.;
RT   "Expression of members of the putative olfactory receptor gene family in
RT   mammalian germ cells.";
RL   Nature 355:453-455(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS ILE-62 AND MET-103.
RC   TISSUE=Cerebellum;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 79-294, AND VARIANT MET-103.
RX   PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA   Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA   Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA   Lehrach H., Lancet D., Shamir R.;
RT   "DEFOG: a practical scheme for deciphering families of genes.";
RL   Genomics 80:295-302(2002).
RN   [5]
RP   IDENTIFICATION, AND VARIANTS ILE-62 AND MET-103.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [6]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR10J1";
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DR   EMBL; X64995; CAA46128.1; -; Genomic_DNA.
DR   EMBL; AL663023; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC069150; AAH69150.1; -; mRNA.
DR   EMBL; BC112290; AAI12291.1; -; mRNA.
DR   EMBL; AF399587; AAK95072.1; -; Genomic_DNA.
DR   EMBL; BK004527; DAA04925.1; -; Genomic_DNA.
DR   PIR; S20573; S20573.
DR   RefSeq; NP_036483.2; NM_012351.2.
DR   AlphaFoldDB; P30954; -.
DR   SMR; P30954; -.
DR   STRING; 9606.ENSP00000492902; -.
DR   GlyCosmos; P30954; 2 sites, No reported glycans.
DR   GlyGen; P30954; 2 sites.
DR   iPTMnet; P30954; -.
DR   PhosphoSitePlus; P30954; -.
DR   BioMuta; OR10J1; -.
DR   DMDM; 292495022; -.
DR   PaxDb; 9606-ENSP00000399078; -.
DR   PeptideAtlas; P30954; -.
DR   Antibodypedia; 57145; 44 antibodies from 13 providers.
DR   DNASU; 26476; -.
DR   Ensembl; ENST00000641630.1; ENSP00000492902.1; ENSG00000196184.10.
DR   Ensembl; ENST00000709168.1; ENSP00000517532.1; ENSG00000291903.1.
DR   GeneID; 26476; -.
DR   KEGG; hsa:26476; -.
DR   UCSC; uc010piv.3; human.
DR   AGR; HGNC:8175; -.
DR   CTD; 26476; -.
DR   DisGeNET; 26476; -.
DR   GeneCards; OR10J1; -.
DR   HGNC; HGNC:8175; OR10J1.
DR   HPA; ENSG00000196184; Tissue enriched (testis).
DR   neXtProt; NX_P30954; -.
DR   OpenTargets; ENSG00000196184; -.
DR   PharmGKB; PA31982; -.
DR   VEuPathDB; HostDB:ENSG00000196184; -.
DR   eggNOG; ENOG502QVH7; Eukaryota.
DR   GeneTree; ENSGT00940000163973; -.
DR   HOGENOM; CLU_012526_5_5_1; -.
DR   InParanoid; P30954; -.
DR   PhylomeDB; P30954; -.
DR   TreeFam; TF337624; -.
DR   PathwayCommons; P30954; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 26476; 15 hits in 752 CRISPR screens.
DR   ChiTaRS; OR10J1; human.
DR   GeneWiki; OR10J1; -.
DR   GenomeRNAi; 26476; -.
DR   Pharos; P30954; Tdark.
DR   PRO; PR:P30954; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; P30954; protein.
DR   Bgee; ENSG00000196184; Expressed in sperm and 14 other cell types or tissues.
DR   ExpressionAtlas; P30954; baseline and differential.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; TAS:ProtInc.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; TAS:ProtInc.
DR   GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; TAS:ProtInc.
DR   GO; GO:0007606; P:sensory perception of chemical stimulus; TAS:ProtInc.
DR   GO; GO:0007338; P:single fertilization; TAS:ProtInc.
DR   CDD; cd15225; 7tmA_OR10A-like; 1.
DR   FunFam; 1.20.1070.10:FF:000001; Olfactory receptor; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR26453; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR26453:SF726; OLFACTORY RECEPTOR 418; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..320
FT                   /note="Olfactory receptor 10J1"
FT                   /id="PRO_0000150707"
FT   TOPO_DOM        1..36
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        37..57
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        58..65
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        66..86
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        87..110
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        111..131
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        132..150
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        151..171
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        172..207
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        208..227
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        228..247
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        248..268
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        269..281
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        282..302
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        303..320
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        9
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        16
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        108..199
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         62
FT                   /note="M -> I (in dbSNP:rs10908722)"
FT                   /evidence="ECO:0000269|PubMed:1370859,
FT                   ECO:0000269|PubMed:14983052, ECO:0000269|PubMed:15489334"
FT                   /id="VAR_034292"
FT   VARIANT         103
FT                   /note="I -> M (in dbSNP:rs12048482)"
FT                   /evidence="ECO:0000269|PubMed:12213199,
FT                   ECO:0000269|PubMed:1370859, ECO:0000269|PubMed:14983052,
FT                   ECO:0000269|PubMed:15489334"
FT                   /id="VAR_053281"
FT   VARIANT         112
FT                   /note="M -> I (in dbSNP:rs12118628)"
FT                   /id="VAR_034293"
SQ   SEQUENCE   320 AA;  35925 MW;  1AA1B612519EFD25 CRC64;
     MLLCFRFGNQ SMKRENFTLI TDFVFQGFSS FHEQQITLFG VFLALYILTL AGNIIIVTII
     RMDLHLHTPM YFFLSMLSTS ETVYTLVILP RMLSSLVGMS QPISLAGCAT QMFFFVTFGI
     TNCFLLTAMG YDRYVAICNP LRYMVIMNKR LRIQLVLGAC SIGLIVAITQ VTSVFRLPFC
     ARKVPHFFCD IRPVMKLSCI DTTVNEILTL IISVLVLVVP MGLVFISYVL IISTILKIAS
     VEGRKKAFAT CASHLTVVIV HYSCASIAYL KPKSENTREH DQLISVTYTV ITPLLNPVVY
     TLRNKEVKDA LCRAVGGKFS
//